Volume 43 Issue 9, September 2011

Volume 43 Issue 9

Cover art: Mendelian Ratio Venn Diagram by A.W.F. Edwards awfe@cam.ac.uk http://www.press.jhu.edu/books/title_pages/3270.html

Editorial

  • Editorial |

    The US Department of Health and Human Services (DHHS) is proposing to enhance federal regulation intended to protect human research subjects, in particular to increase measures aimed at security of personal data. Since the ethical review process is partially based on respect for people and their autonomy, harmonization of these rules will be a process of convincing individuals and their states to accept uniform standards that give enough privacy but do not lock away personal data from either research participants or researchers.

News and Views

  • News & Views |

    Advances in both pedigree-based and population-based genetic maps in recent years have helped unravel some of the mysteries of human meiotic recombination. The publication of the first admixture-derived human genetic maps offers a new approach for inferring recombination events and provides insight into variation in recombination rate patterns across populations.

    • Paul F O'Reilly
    •  & David J Balding
  • News & Views |

    A new study shows that the PTPN22 coding variant associated with autoimmunity is a loss-of-function allele that causes the protein tyrosine phosphatase encoded by PTPN22 to undergo accelerated degradation, resulting in enhanced signaling in several immune cell types.

    • Timothy W Behrens
  • News & Views |

    Complex autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, psoriasis and inflammatory bowel disease have different pathological presentations but have overlapping genetic susceptibility variants. A new study using mice lacking Tnfaip3, whose ortholog is linked to autoimmune disease in humans, leads to insights in the role of one molecular driver of varied clinical symptomatology in disparate autoimmune disorders.

    • Flavius Martin
    •  & Vishva M Dixit

Research Highlights

Brief Communications

  • Brief Communication |

    Richard Houlston, Matthias Simon and colleagues report that common variation at 10p12.31 influences meningioma susceptibility. The risk variants are located upstream of MLLT10, which encodes an activator of Wnt-dependent transcription.

    • Sara E Dobbins
    • , Peter Broderick
    • , Beatrice Melin
    • , Maria Feychting
    • , Christoffer Johansen
    • , Ulrika Andersson
    • , Thomas Brännström
    • , Johannes Schramm
    • , Bianca Olver
    • , Amy Lloyd
    • , Yussanne P Ma
    • , Fay J Hosking
    • , Stefan Lönn
    • , Anders Ahlbom
    • , Roger Henriksson
    • , Minouk J Schoemaker
    • , Sarah J Hepworth
    • , Per Hoffmann
    • , Thomas W Mühleisen
    • , Markus M Nöthen
    • , Susanne Moebus
    • , Lewin Eisele
    • , Michael Kosteljanetz
    • , Kenneth Muir
    • , Anthony Swerdlow
    • , Matthias Simon
    •  & Richard S Houlston
  • Brief Communication |

    Kenneth Kinzler and colleagues report exome sequencing of ten hepatocellular carcinoma tumors and matched normal tissue. They identify inactivating mutations in the chromatin remodeling gene ARID2 in a total of 9 out of 139 HCC tumors.

    • Meng Li
    • , Hong Zhao
    • , Xiaosong Zhang
    • , Laura D Wood
    • , Robert A Anders
    • , Michael A Choti
    • , Timothy M Pawlik
    • , Hubert D Daniel
    • , Rajesh Kannangai
    • , G Johan A Offerhaus
    • , Victor E Velculescu
    • , Linfang Wang
    • , Shibin Zhou
    • , Bert Vogelstein
    • , Ralph H Hruban
    • , Nick Papadopoulos
    • , Jianqiang Cai
    • , Michael S Torbenson
    •  & Kenneth W Kinzler

Articles

  • Article |

    Laura Pasqualucci and Riccardo Dalla-Favera and colleagues report exome sequencing and copy-number analyses of diffuse large B-cell lymphomas. Their analyses identified mutations in genes not previously implicated in DLBCL pathogenesis, such as genes encoding chromatin modifiers such as MLL2.

    • Laura Pasqualucci
    • , Vladimir Trifonov
    • , Giulia Fabbri
    • , Jing Ma
    • , Davide Rossi
    • , Annalisa Chiarenza
    • , Victoria A Wells
    • , Adina Grunn
    • , Monica Messina
    • , Oliver Elliot
    • , Joseph Chan
    • , Govind Bhagat
    • , Amy Chadburn
    • , Gianluca Gaidano
    • , Charles G Mullighan
    • , Raul Rabadan
    •  & Riccardo Dalla-Favera
  • Article |

    Evan Eichler and colleagues analyze copy number variation in 15,767 children with intellectual disability, developmental delay, congenital birth defects and/or other related phenotypes. They identify 59 likely pathogenic CNV regions, including 14 new candidate regions, and estimate that ~14% of disorders in this sample collection are caused by large CNVs.

    • Gregory M Cooper
    • , Bradley P Coe
    • , Santhosh Girirajan
    • , Jill A Rosenfeld
    • , Tiffany H Vu
    • , Carl Baker
    • , Charles Williams
    • , Heather Stalker
    • , Rizwan Hamid
    • , Vickie Hannig
    • , Hoda Abdel-Hamid
    • , Patricia Bader
    • , Elizabeth McCracken
    • , Dmitriy Niyazov
    • , Kathleen Leppig
    • , Heidi Thiese
    • , Marybeth Hummel
    • , Nora Alexander
    • , Jerome Gorski
    • , Jennifer Kussmann
    • , Vandana Shashi
    • , Krys Johnson
    • , Catherine Rehder
    • , Blake C Ballif
    • , Lisa G Shaffer
    •  & Evan E Eichler
  • Article |

    John Novembre and colleagues present a new approach for constructing recombination maps based on ancestry switch points among individuals. They construct a high-resolution genome-wide recombination map based on admixed African-American and African-Caribbean individuals and compare this to previous recombination maps.

    • Daniel Wegmann
    • , Darren E Kessner
    • , Krishna R Veeramah
    • , Rasika A Mathias
    • , Dan L Nicolae
    • , Lisa R Yanek
    • , Yan V Sun
    • , Dara G Torgerson
    • , Nicholas Rafaels
    • , Thomas Mosley
    • , Lewis C Becker
    • , Ingo Ruczinski
    • , Terri H Beaty
    • , Sharon L R Kardia
    • , Deborah A Meyers
    • , Kathleen C Barnes
    • , Diane M Becker
    • , Nelson B Freimer
    •  & John Novembre
  • Article |

    Alexander van Oudenaarden and colleagues examine microRNA-mediated regulation of gene expression using single-cell measurements of a target gene's expression. They find that microRNAs can repress gene expression either as a switch or through fine-tuning and that the strength of repression can vary widely between cells.

    • Shankar Mukherji
    • , Margaret S Ebert
    • , Grace X Y Zheng
    • , John S Tsang
    • , Phillip A Sharp
    •  & Alexander van Oudenaarden

Letters

  • Letter |

    Guy Rouleau, Marie-Odile Krebs and colleagues sequenced the exomes of 14 individuals with schizophrenia and their unaffected parents. Their findings support a role for de novo mutations in the etiology of schizophrenia and provide a list of genes that may contribute to disease pathogenesis.

    • Simon L Girard
    • , Julie Gauthier
    • , Anne Noreau
    • , Lan Xiong
    • , Sirui Zhou
    • , Loubna Jouan
    • , Alexandre Dionne-Laporte
    • , Dan Spiegelman
    • , Edouard Henrion
    • , Ousmane Diallo
    • , Pascale Thibodeau
    • , Isabelle Bachand
    • , Jessie Y J Bao
    • , Amy Hin Yan Tong
    • , Chi-Ho Lin
    • , Bruno Millet
    • , Nematollah Jaafari
    • , Ridha Joober
    • , Patrick A Dion
    • , Si Lok
    • , Marie-Odile Krebs
    •  & Guy A Rouleau
  • Letter |

    Maria Karayiorgou, Joseph Gogos and colleagues sequenced the exomes of 53 sporadic schizophrenia cases and their parents as well as 22 unaffected control trios. They identified a large excess of non-synonymous de novo mutations in cases, supporting a role for de novo mutations in the etiology of this disease.

    • Bin Xu
    • , J Louw Roos
    • , Phillip Dexheimer
    • , Braden Boone
    • , Brooks Plummer
    • , Shawn Levy
    • , Joseph A Gogos
    •  & Maria Karayiorgou
  • Letter |

    Jason Locasale, Lewis Cantley, Matthew Vander Heiden and colleagues show that PHGDH is amplified in some human cancers and diverts a relatively large amount of glycolytic carbon into serine and glycine biosynthesis. They further show that PHGDH-amplified cancer cells become dependent on PHGDH for their growth, suggesting that the altered metabolic flux driven by this amplification contributes to oncogenesis.

    • Jason W Locasale
    • , Alexandra R Grassian
    • , Tamar Melman
    • , Costas A Lyssiotis
    • , Katherine R Mattaini
    • , Adam J Bass
    • , Gregory Heffron
    • , Christian M Metallo
    • , Taru Muranen
    • , Hadar Sharfi
    • , Atsuo T Sasaki
    • , Dimitrios Anastasiou
    • , Edouard Mullarky
    • , Natalie I Vokes
    • , Mika Sasaki
    • , Rameen Beroukhim
    • , Gregory Stephanopoulos
    • , Azra H Ligon
    • , Matthew Meyerson
    • , Andrea L Richardson
    • , Lynda Chin
    • , Gerhard Wagner
    • , John M Asara
    • , Joan S Brugge
    • , Lewis C Cantley
    •  & Matthew G Vander Heiden
  • Letter |

    Zhiming Cai and colleagues report the exome sequencing of tumor and matched normal tissue from nine transitional cell carcinomas (TCCs) of the bladder, with further screening in 88 additional subjects. The authors identify mutations in chromatin remodeling genes in 59% of the 97 TCC subjects.

    • Yaoting Gui
    • , Guangwu Guo
    • , Yi Huang
    • , Xueda Hu
    • , Aifa Tang
    • , Shengjie Gao
    • , Renhua Wu
    • , Chao Chen
    • , Xianxin Li
    • , Liang Zhou
    • , Minghui He
    • , Zesong Li
    • , Xiaojuan Sun
    • , Wenlong Jia
    • , Jinnong Chen
    • , Shangming Yang
    • , Fangjian Zhou
    • , Xiaokun Zhao
    • , Shengqing Wan
    • , Rui Ye
    • , Chaozhao Liang
    • , Zhisheng Liu
    • , Peide Huang
    • , Chunxiao Liu
    • , Hui Jiang
    • , Yong Wang
    • , Hancheng Zheng
    • , Liang Sun
    • , Xingwang Liu
    • , Zhimao Jiang
    • , Dafei Feng
    • , Jing Chen
    • , Song Wu
    • , Jing Zou
    • , Zhongfu Zhang
    • , Ruilin Yang
    • , Jun Zhao
    • , Congjie Xu
    • , Weihua Yin
    • , Zhichen Guan
    • , Jiongxian Ye
    • , Hong Zhang
    • , Jingxiang Li
    • , Karsten Kristiansen
    • , Michael L Nickerson
    • , Dan Theodorescu
    • , Yingrui Li
    • , Xiuqing Zhang
    • , Songgang Li
    • , Jian Wang
    • , Huanming Yang
    • , Jun Wang
    •  & Zhiming Cai
  • Letter |

    Nazneen Rahman and colleagues show that germline inactivating mutations in RAD51D confer susceptibility to ovarian cancer. They further show that RAD51D-deficient cells are sensitive to PARP inhibition, suggesting a possible strategy for treating cancers arising in RAD51D mutation carriers.

    • Chey Loveday
    • , Clare Turnbull
    • , Emma Ramsay
    • , Deborah Hughes
    • , Elise Ruark
    • , Jessica R Frankum
    • , Georgina Bowden
    • , Bolot Kalmyrzaev
    • , Margaret Warren-Perry
    • , Katie Snape
    • , Julian W Adlard
    • , Julian Barwell
    • , Jonathan Berg
    • , Angela F Brady
    • , Carole Brewer
    • , Glen Brice
    • , Cyril Chapman
    • , Jackie Cook
    • , Rosemarie Davidson
    • , Alan Donaldson
    • , Fiona Douglas
    • , Lynn Greenhalgh
    • , Alex Henderson
    • , Louise Izatt
    • , Ajith Kumar
    • , Fiona Lalloo
    • , Zosia Miedzybrodzka
    • , Patrick J Morrison
    • , Joan Paterson
    • , Mary Porteous
    • , Mark T Rogers
    • , Susan Shanley
    • , Lisa Walker
    • , Breast Cancer Susceptibility Collaboration (UK)
    • , Diana Eccles
    • , D Gareth Evans
    • , Anthony Renwick
    • , Sheila Seal
    • , Christopher J Lord
    • , Alan Ashworth
    • , Jorge S Reis-Filho
    • , Antonis C Antoniou
    •  & Nazneen Rahman
  • Letter |

    Leslie Biesecker and colleagues report exome sequencing of an individual with combined malonic and methylmalonic aciduria (CMAMMA). With follow-up sequencing of an additional eight cases, they confirm ACSF3 as a cause of CMAMMA. They further report a canine model for CMAMMA that has a mutation in a putative ACSF3 ortholog.

    • Jennifer L Sloan
    • , Jennifer J Johnston
    • , Irini Manoli
    • , Randy J Chandler
    • , Caitlin Krause
    • , Nuria Carrillo-Carrasco
    • , Suma D Chandrasekaran
    • , Justin R Sysol
    • , Kevin O'Brien
    • , Natalie S Hauser
    • , Julie C Sapp
    • , Heidi M Dorward
    • , Marjan Huizing
    • , NIH Intramural Sequencing Center Group
    • , Bruce A Barshop
    • , Susan A Berry
    • , Philip M James
    • , Neena L Champaigne
    • , Pascale de Lonlay
    • , Vassilli Valayannopoulos
    • , Michael D Geschwind
    • , Dimitar K Gavrilov
    • , William L Nyhan
    • , Leslie G Biesecker
    •  & Charles P Venditti
  • Letter |

    Dan Nicolae, Carole Ober and colleagues report a meta-analysis of genome-wide association studies for asthma in a collection of ethnically diverse North American populations. They identify a newly associated susceptibility locus at PYHIN1 in individuals of African descent.

    • Mexico City Childhood Asthma Study (MCAAS)
    • , Dara G Torgerson
    • , Elizabeth J Ampleford
    • , Grace Y Chiu
    • , W James Gauderman
    • , Christopher R Gignoux
    • , Penelope E Graves
    • , Blanca E Himes
    • , Albert M Levin
    • , Rasika A Mathias
    • , Dana B Hancock
    • , James W Baurley
    • , Celeste Eng
    • , Debra A Stern
    • , Juan C Celedón
    • , Nicholas Rafaels
    • , Daniel Capurso
    • , David V Conti
    • , Lindsey A Roth
    • , Manuel Soto-Quiros
    • , Alkis Togias
    • , Xingnan Li
    • , Rachel A Myers
    • , Isabelle Romieu
    • , David J Van Den Berg
    • , Donglei Hu
    • , Nadia N Hansel
    • , Ryan D Hernandez
    • , Elliott Israel
    • , Muhammad T Salam
    • , Joshua Galanter
    • , Pedro C Avila
    • , Lydiana Avila
    • , Jose R Rodriquez-Santana
    • , Rocio Chapela
    • , William Rodriguez-Cintron
    • , Gregory B Diette
    • , N Franklin Adkinson
    • , Rebekah A Abel
    • , Kevin D Ross
    • , Min Shi
    • , Mezbah U Faruque
    • , Georgia M Dunston
    • , Harold R Watson
    • , Vito J Mantese
    • , Serpil C Ezurum
    • , Liming Liang
    • , Ingo Ruczinski
    • , Jean G Ford
    • , Scott Huntsman
    • , Kian Fan Chung
    • , Hita Vora
    • , Xia Li
    • , William J Calhoun
    • , Mario Castro
    • , Juan J Sienra-Monge
    • , Blanca del Rio-Navarro
    • , Klaus A Deichmann
    • , Andrea Heinzmann
    • , Sally E Wenzel
    • , William W Busse
    • , James E Gern
    • , Robert F Lemanske Jr
    • , Terri H Beaty
    • , Eugene R Bleecker
    • , Benjamin A Raby
    • , Deborah A Meyers
    • , Stephanie J London
    • , Children's Health Study (CHS) and HARBORS study
    • , Frank D Gilliland
    • , Genetics of Asthma in Latino Americans (GALA) Study, the Study of Genes-Environment and Admixture in Latino Americans (GALA2) and the Study of African Americans, Asthma, Genes & Environments (SAGE)
    • , Esteban G Burchard
    • , Childhood Asthma Research and Education (CARE) Network
    • , Fernando D Martinez
    • , Childhood Asthma Management Program (CAMP)
    • , Scott T Weiss
    • , Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE)
    • , L Keoki Williams
    • , Genetic Research on Asthma in the African Diaspora (GRAAD) Study
    • , Kathleen C Barnes
    • , Carole Ober
    •  & Dan L Nicolae
  • Letter |

    Mayumi Tamari and colleagues report a genome-wide association study for adult asthma in a Japanese population. They identify three new asthma susceptibility loci.

    • Tomomitsu Hirota
    • , Atsushi Takahashi
    • , Michiaki Kubo
    • , Tatsuhiko Tsunoda
    • , Kaori Tomita
    • , Satoru Doi
    • , Kimie Fujita
    • , Akihiko Miyatake
    • , Tadao Enomoto
    • , Takehiko Miyagawa
    • , Mitsuru Adachi
    • , Hiroshi Tanaka
    • , Akio Niimi
    • , Hisako Matsumoto
    • , Isao Ito
    • , Hironori Masuko
    • , Tohru Sakamoto
    • , Nobuyuki Hizawa
    • , Masami Taniguchi
    • , John J Lima
    • , Charles G Irvin
    • , Stephen P Peters
    • , Blanca E Himes
    • , Augusto A Litonjua
    • , Kelan G Tantisira
    • , Scott T Weiss
    • , Naoyuki Kamatani
    • , Yusuke Nakamura
    •  & Mayumi Tamari
  • Letter |

    Huai-Dong Song and colleagues report results of a genome-wide association study of Graves' disease. They confirm four previously reported risk loci for this disease and identify two new susceptibility loci at 4p14 and 6q27.

    • The China Consortium for the Genetics of Autoimmune Thyroid Disease
    • , Xun Chu
    • , Chun-Ming Pan
    • , Shuang-Xia Zhao
    • , Jun Liang
    • , Guan-Qi Gao
    • , Xiao-Mei Zhang
    • , Guo-Yue Yuan
    • , Chang-Gui Li
    • , Li-Qiong Xue
    • , Min Shen
    • , Wei Liu
    • , Fang Xie
    • , Shao-Ying Yang
    • , Hai-Feng Wang
    • , Jing-Yi Shi
    • , Wei-Wei Sun
    • , Wen-Hua Du
    • , Chun-Lin Zuo
    • , Jin-Xiu Shi
    • , Bing-Li Liu
    • , Cui-Cui Guo
    • , Ming Zhan
    • , Zhao-Hui Gu
    • , Xiao-Na Zhang
    • , Fei Sun
    • , Zhi-Quan Wang
    • , Zhi-Yi Song
    • , Cai-Yan Zou
    • , Wei-Hua Sun
    • , Ting Guo
    • , Huang-Ming Cao
    • , Jun-Hua Ma
    • , Bing Han
    • , Ping Li
    • , He Jiang
    • , Qiu-Hua Huang
    • , Liming Liang
    • , Li-Bin Liu
    • , Gang Chen
    • , Qing Su
    • , Yong-De Peng
    • , Jia-Jun Zhao
    • , Guang Ning
    • , Zhu Chen
    • , Jia-Lun Chen
    • , Sai-Juan Chen
    • , Wei Huang
    •  & Huai-Dong Song
  • Letter |

    Katherine Siminovitch and colleagues show that mice expressing the autoimmune disease–associated Ptpn22 coding variant show thymic and splenic enlargement and lymphocyte and dendritic cell hyperresponsiveness. They further show that the variant promotes degradation of the protein, suggesting that it enhances autoimmune disease risk through a loss-of-function mechanism.

    • Jinyi Zhang
    • , Naima Zahir
    • , Qiuhong Jiang
    • , Helen Miliotis
    • , Stephanie Heyraud
    • , Xianwang Meng
    • , Baoxia Dong
    • , Gang Xie
    • , Frank Qiu
    • , Zhenyue Hao
    • , Christopher A McCulloch
    • , Edward C Keystone
    • , Alan C Peterson
    •  & Katherine A Siminovitch
  • Letter |

    Geert van Loo, Rudi Beyaert, Dirk Elewaut and colleagues report that myeloid-specific deletion of Tnfaip3 in mice causes spontaneous destructive polyarthritis that resembles rheumatoid arthritis. Tnfaip3 encodes the A20 protein, which is involved in negative regulation of NF-κB signaling in response to proinflammatory stimuli.

    • Mourad Matmati
    • , Peggy Jacques
    • , Jonathan Maelfait
    • , Eveline Verheugen
    • , Mirjam Kool
    • , Mozes Sze
    • , Lies Geboes
    • , Els Louagie
    • , Conor Mc Guire
    • , Lars Vereecke
    • , Yuanyuan Chu
    • , Louis Boon
    • , Steven Staelens
    • , Patrick Matthys
    • , Bart N Lambrecht
    • , Marc Schmidt-Supprian
    • , Manolis Pasparakis
    • , Dirk Elewaut
    • , Rudi Beyaert
    •  & Geert van Loo
  • Letter |

    Dong-Ha Oh and colleagues report the draft genome of the extremophile crucifer plant Thellungiella parvula. This species is endemic to highly saline environments subject to extreme temperatures. The genome was primarily assembled using next-generation sequencing data.

    • Maheshi Dassanayake
    • , Dong-Ha Oh
    • , Jeffrey S Haas
    • , Alvaro Hernandez
    • , Hyewon Hong
    • , Shahjahan Ali
    • , Dae-Jin Yun
    • , Ray A Bressan
    • , Jian-Kang Zhu
    • , Hans J Bohnert
    •  & John M Cheeseman

Corrigenda

  • Corrigendum |

    • Carl A Anderson
    • , Gabrielle Boucher
    • , Charlie W Lees
    • , Andre Franke
    • , Mauro D'Amato
    • , Kent D Taylor
    • , James C Lee
    • , Philippe Goyette
    • , Marcin Imielinski
    • , Anna Latiano
    • , Caroline Lagacé
    • , Regan Scott
    • , Leila Amininejad
    • , Suzannah Bumpstead
    • , Leonard Baidoo
    • , Robert N Baldassano
    • , Murray Barclay
    • , Theodore M Bayless
    • , Stephan Brand
    • , Carsten Büning
    • , Jean-Frédéric Colombel
    • , Lee A Denson
    • , Martine De Vos
    • , Marla Dubinsky
    • , Cathryn Edwards
    • , David Ellinghaus
    • , Rudolf S N Fehrmann
    • , James A B Floyd
    • , Timothy Florin
    • , Denis Franchimont
    • , Lude Franke
    • , Michel Georges
    • , Jürgen Glas
    • , Nicole L Glazer
    • , Stephen L Guthery
    • , Talin Haritunians
    • , Nicholas K Hayward
    • , Jean-Pierre Hugot
    • , Gilles Jobin
    • , Debby Laukens
    • , Ian Lawrance
    • , Marc Lémann
    • , Arie Levine
    • , Cecile Libioulle
    • , Edouard Louis
    • , Dermot P McGovern
    • , Monica Milla
    • , Grant W Montgomery
    • , Katherine I Morley
    • , Craig Mowat
    • , Aylwin Ng
    • , William Newman
    • , Roel A Ophoff
    • , Laura Papi
    • , Orazio Palmieri
    • , Laurent Peyrin-Biroulet
    • , Julián Panés
    • , Anne Phillips
    • , Natalie J Prescott
    • , Deborah D Proctor
    • , Rebecca Roberts
    • , Richard Russell
    • , Paul Rutgeerts
    • , Jeremy Sanderson
    • , Miquel Sans
    • , Philip Schumm
    • , Frank Seibold
    • , Yashoda Sharma
    • , Lisa A Simms
    • , Mark Seielstad
    • , A Hillary Steinhart
    • , Stephan R Targan
    • , Leonard H van den Berg
    • , Morten Vatn
    • , Hein Verspaget
    • , Thomas Walters
    • , Cisca Wijmenga
    • , David C Wilson
    • , Harm-Jan Westra
    • , Ramnik J Xavier
    • , Zhen Z Zhao
    • , Cyriel Y Ponsioen
    • , Vibeke Andersen
    • , Leif Torkvist
    • , Maria Gazouli
    • , Nicholas P Anagnou
    • , Tom H Karlsen
    • , Limas Kupcinskas
    • , Jurgita Sventoraityte
    • , John C Mansfield
    • , Subra Kugathasan
    • , Mark S Silverberg
    • , Jonas Halfvarson
    • , Jerome I Rotter
    • , Christopher G Mathew
    • , Anne M Griffiths
    • , Richard Gearry
    • , Tariq Ahmad
    • , Steven R Brant
    • , Mathias Chamaillard
    • , Jack Satsangi
    • , Judy H Cho
    • , Stefan Schreiber
    • , Mark J Daly
    • , Jeffrey C Barrett
    • , Miles Parkes
    • , Vito Annese
    • , Hakon Hakonarson
    • , Graham Radford-Smith
    • , Richard H Duerr
    • , Séverine Vermeire
    • , Rinse K Weersma
    •  & John D Rioux