Volume 43 Issue 5, May 2011

Volume 43 Issue 5

Cover art: ramie 1 by Elizabeth Gourlay from eo art lab http://eoartlab.com/

Editorial

  • Editorial |

    More data than we can handle is no excuse to give up our efforts to promote data access, but it may make us think about new ways to make it sustainable.

Correspondence

News and Views

  • News & Views |

    Identifying causal variants for complex traits and understanding their function remain arduous tasks. A new study combines the advantages of gene mapping in livestock with elegant genetic and functional analyses to address these challenges and identifies candidate regulatory variants affecting stature in cattle.

    • Peter M Visscher
    •  & Michael E Goddard
  • News & Views |

    A study characterizes the in vitro replicative capacity of over 70,000 clinical isolates of HIV-1 in the absence of drugs, or in the presence of one of 15 individual drugs. The largest survey of the effects of mutations on fitness undertaken in any organism, this study finds extensive pairwise interactions among over 1,800 variable sites identified through sequencing the protease and reverse transcriptase genes.

    • Daniel M Weinreich
  • News & Views |

    Current models of Mycobacterium tuberculosis latency presume very low mycobacterial replication and mutation rates. In contrast to these models, a study reporting whole-genome sequencing of mycobacteria isolated from infected macaques shows that the mutational capacity of M. tuberculosis during latency is not reduced, a finding with important implications for tuberculosis research and control.

    • David R Sherman
    •  & Sebastien Gagneux

Research Highlights

Articles

  • Article |

    Michel Georges and colleagues report fine mapping and functional characterization of a quantitative trait locus with a large effect on bovine stature. They show that the likely causal variants at this locus modulate expression of a chromosomal domain encompassing PLAG1 and several other genes.

    • Latifa Karim
    • , Haruko Takeda
    • , Li Lin
    • , Tom Druet
    • , Juan A C Arias
    • , Denis Baurain
    • , Nadine Cambisano
    • , Stephen R Davis
    • , Frédéric Farnir
    • , Bernard Grisart
    • , Bevin L Harris
    • , Mike D Keehan
    • , Mathew D Littlejohn
    • , Richard J Spelman
    • , Michel Georges
    •  & Wouter Coppieters
  • Article |

    Julia Zeitlinger, Alexander Stark and colleagues report genome-wide binding profiles for the transcription factor Twist across six Drosophila species. They find that the binding pattern is highly conserved across species, suggesting strong functional constraints at the enhancers that Twist regulates.

    • Qiye He
    • , Anaïs F Bardet
    • , Brianne Patton
    • , Jennifer Purvis
    • , Jeff Johnston
    • , Ariel Paulson
    • , Madelaine Gogol
    • , Alexander Stark
    •  & Julia Zeitlinger
  • Article |

    Pradeep Kachroo and colleagues show that glycerol-3-phosphate is a critical mobile inducer of systemic acquired resistance in plants.

    • Bidisha Chanda
    • , Ye Xia
    • , Mihir Kumar Mandal
    • , Keshun Yu
    • , Ken‐Taro Sekine
    • , Qing-ming Gao
    • , Devarshi Selote
    • , Yanling Hu
    • , Arnold Stromberg
    • , Duroy Navarre
    • , Aardra Kachroo
    •  & Pradeep Kachroo

Letters

  • Letter |

    Julie Williams, Michael Owen and colleagues report staged follow-up and meta-analyses of genome-wide association studies for Alzheimer's disease from the GERAD+ consortium. They identify common variants at ABCA7 and MS4A6A/MS4A4E associated with Alzheimer's disease and support for several additional susceptibility loci.

    • Paul Hollingworth
    • , Denise Harold
    • , Rebecca Sims
    • , Amy Gerrish
    • , Jean-Charles Lambert
    • , Minerva M Carrasquillo
    • , Richard Abraham
    • , Marian L Hamshere
    • , Jaspreet Singh Pahwa
    • , Valentina Moskvina
    • , Kimberley Dowzell
    • , Nicola Jones
    • , Alexandra Stretton
    • , Charlene Thomas
    • , Alex Richards
    • , Dobril Ivanov
    • , Caroline Widdowson
    • , Jade Chapman
    • , Simon Lovestone
    • , John Powell
    • , Petroula Proitsi
    • , Michelle K Lupton
    • , Carol Brayne
    • , David C Rubinsztein
    • , Michael Gill
    • , Brian Lawlor
    • , Aoibhinn Lynch
    • , Kristelle S Brown
    • , Peter A Passmore
    • , David Craig
    • , Bernadette McGuinness
    • , Stephen Todd
    • , Clive Holmes
    • , David Mann
    • , A David Smith
    • , Helen Beaumont
    • , Donald Warden
    • , Gordon Wilcock
    • , Seth Love
    • , Patrick G Kehoe
    • , Nigel M Hooper
    • , Emma R L C Vardy
    • , John Hardy
    • , Simon Mead
    • , Nick C Fox
    • , Martin Rossor
    • , John Collinge
    • , Wolfgang Maier
    • , Frank Jessen
    • , Eckart Rüther
    • , Britta Schürmann
    • , Reiner Heun
    • , Heike Kölsch
    • , Hendrik van den Bussche
    • , Isabella Heuser
    • , Johannes Kornhuber
    • , Jens Wiltfang
    • , Martin Dichgans
    • , Lutz Frölich
    • , Harald Hampel
    • , John Gallacher
    • , Michael Hüll
    • , Dan Rujescu
    • , Ina Giegling
    • , Alison M Goate
    • , John S K Kauwe
    • , Carlos Cruchaga
    • , Petra Nowotny
    • , John C Morris
    • , Kevin Mayo
    • , Kristel Sleegers
    • , Karolien Bettens
    • , Sebastiaan Engelborghs
    • , Peter P De Deyn
    • , Christine Van Broeckhoven
    • , Gill Livingston
    • , Nicholas J Bass
    • , Hugh Gurling
    • , Andrew McQuillin
    • , Rhian Gwilliam
    • , Panagiotis Deloukas
    • , Ammar Al-Chalabi
    • , Christopher E Shaw
    • , Magda Tsolaki
    • , Andrew B Singleton
    • , Rita Guerreiro
    • , Thomas W Mühleisen
    • , Markus M Nöthen
    • , Susanne Moebus
    • , Karl-Heinz Jöckel
    • , Norman Klopp
    • , H-Erich Wichmann
    • , V Shane Pankratz
    • , Sigrid B Sando
    • , Jan O Aasly
    • , Maria Barcikowska
    • , Zbigniew K Wszolek
    • , Dennis W Dickson
    • , Neill R Graff-Radford
    • , Ronald C Petersen
    • , the Alzheimer's Disease Neuroimaging Initiative
    • , Cornelia M van Duijn
    • , Monique M B Breteler
    • , M Arfan Ikram
    • , Anita L DeStefano
    • , Annette L Fitzpatrick
    • , Oscar Lopez
    • , Lenore J Launer
    • , Sudha Seshadri
    • , CHARGE consortium
    • , Claudine Berr
    • , Dominique Campion
    • , Jacques Epelbaum
    • , Jean-François Dartigues
    • , Christophe Tzourio
    • , Annick Alpérovitch
    • , Mark Lathrop
    • , EADI1 consortium
    • , Thomas M Feulner
    • , Patricia Friedrich
    • , Caterina Riehle
    • , Michael Krawczak
    • , Stefan Schreiber
    • , Manuel Mayhaus
    • , S Nicolhaus
    • , Stefan Wagenpfeil
    • , Stacy Steinberg
    • , Hreinn Stefansson
    • , Kari Stefansson
    • , Jon Snædal
    • , Sigurbjörn Björnsson
    • , Palmi V Jonsson
    • , Vincent Chouraki
    • , Benjamin Genier-Boley
    • , Mikko Hiltunen
    • , Hilkka Soininen
    • , Onofre Combarros
    • , Diana Zelenika
    • , Marc Delepine
    • , Maria J Bullido
    • , Florence Pasquier
    • , Ignacio Mateo
    • , Ana Frank-Garcia
    • , Elisa Porcellini
    • , Olivier Hanon
    • , Eliecer Coto
    • , Victoria Alvarez
    • , Paolo Bosco
    • , Gabriele Siciliano
    • , Michelangelo Mancuso
    • , Francesco Panza
    • , Vincenzo Solfrizzi
    • , Benedetta Nacmias
    • , Sandro Sorbi
    • , Paola Bossù
    • , Paola Piccardi
    • , Beatrice Arosio
    • , Giorgio Annoni
    • , Davide Seripa
    • , Alberto Pilotto
    • , Elio Scarpini
    • , Daniela Galimberti
    • , Alexis Brice
    • , Didier Hannequin
    • , Federico Licastro
    • , Lesley Jones
    • , Peter A Holmans
    • , Thorlakur Jonsson
    • , Matthias Riemenschneider
    • , Kevin Morgan
    • , Steven G Younkin
    • , Michael J Owen
    • , Michael O'Donovan
    • , Philippe Amouyel
    •  & Julie Williams
  • Letter |

    Gerard Schellenberg and colleagues report a genome-wide association study of late-onset Alzheimer's disease (LOAD), as part of the Alzheimer Disease Genetics Consortium. They identify common variants in MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 associated with LOAD.

    • Adam C Naj
    • , Gyungah Jun
    • , Gary W Beecham
    • , Li-San Wang
    • , Badri Narayan Vardarajan
    • , Jacqueline Buros
    • , Paul J Gallins
    • , Joseph D Buxbaum
    • , Gail P Jarvik
    • , Paul K Crane
    • , Eric B Larson
    • , Thomas D Bird
    • , Bradley F Boeve
    • , Neill R Graff-Radford
    • , Philip L De Jager
    • , Denis Evans
    • , Julie A Schneider
    • , Minerva M Carrasquillo
    • , Nilufer Ertekin-Taner
    • , Steven G Younkin
    • , Carlos Cruchaga
    • , John S K Kauwe
    • , Petra Nowotny
    • , Patricia Kramer
    • , John Hardy
    • , Matthew J Huentelman
    • , Amanda J Myers
    • , Michael M Barmada
    • , F Yesim Demirci
    • , Clinton T Baldwin
    • , Robert C Green
    • , Ekaterina Rogaeva
    • , Peter St George-Hyslop
    • , Steven E Arnold
    • , Robert Barber
    • , Thomas Beach
    • , Eileen H Bigio
    • , James D Bowen
    • , Adam Boxer
    • , James R Burke
    • , Nigel J Cairns
    • , Chris S Carlson
    • , Regina M Carney
    • , Steven L Carroll
    • , Helena C Chui
    • , David G Clark
    • , Jason Corneveaux
    • , Carl W Cotman
    • , Jeffrey L Cummings
    • , Charles DeCarli
    • , Steven T DeKosky
    • , Ramon Diaz-Arrastia
    • , Malcolm Dick
    • , Dennis W Dickson
    • , William G Ellis
    • , Kelley M Faber
    • , Kenneth B Fallon
    • , Martin R Farlow
    • , Steven Ferris
    • , Matthew P Frosch
    • , Douglas R Galasko
    • , Mary Ganguli
    • , Marla Gearing
    • , Daniel H Geschwind
    • , Bernardino Ghetti
    • , John R Gilbert
    • , Sid Gilman
    • , Bruno Giordani
    • , Jonathan D Glass
    • , John H Growdon
    • , Ronald L Hamilton
    • , Lindy E Harrell
    • , Elizabeth Head
    • , Lawrence S Honig
    • , Christine M Hulette
    • , Bradley T Hyman
    • , Gregory A Jicha
    • , Lee-Way Jin
    • , Nancy Johnson
    • , Jason Karlawish
    • , Anna Karydas
    • , Jeffrey A Kaye
    • , Ronald Kim
    • , Edward H Koo
    • , Neil W Kowall
    • , James J Lah
    • , Allan I Levey
    • , Andrew P Lieberman
    • , Oscar L Lopez
    • , Wendy J Mack
    • , Daniel C Marson
    • , Frank Martiniuk
    • , Deborah C Mash
    • , Eliezer Masliah
    • , Wayne C McCormick
    • , Susan M McCurry
    • , Andrew N McDavid
    • , Ann C McKee
    • , Marsel Mesulam
    • , Bruce L Miller
    • , Carol A Miller
    • , Joshua W Miller
    • , Joseph E Parisi
    • , Daniel P Perl
    • , Elaine Peskind
    • , Ronald C Petersen
    • , Wayne W Poon
    • , Joseph F Quinn
    • , Ruchita A Rajbhandary
    • , Murray Raskind
    • , Barry Reisberg
    • , John M Ringman
    • , Erik D Roberson
    • , Roger N Rosenberg
    • , Mary Sano
    • , Lon S Schneider
    • , William Seeley
    • , Michael L Shelanski
    • , Michael A Slifer
    • , Charles D Smith
    • , Joshua A Sonnen
    • , Salvatore Spina
    • , Robert A Stern
    • , Rudolph E Tanzi
    • , John Q Trojanowski
    • , Juan C Troncoso
    • , Vivianna M Van Deerlin
    • , Harry V Vinters
    • , Jean Paul Vonsattel
    • , Sandra Weintraub
    • , Kathleen A Welsh-Bohmer
    • , Jennifer Williamson
    • , Randall L Woltjer
    • , Laura B Cantwell
    • , Beth A Dombroski
    • , Duane Beekly
    • , Kathryn L Lunetta
    • , Eden R Martin
    • , M Ilyas Kamboh
    • , Andrew J Saykin
    • , Eric M Reiman
    • , David A Bennett
    • , John C Morris
    • , Thomas J Montine
    • , Alison M Goate
    • , Deborah Blacker
    • , Debby W Tsuang
    • , Hakon Hakonarson
    • , Walter A Kukull
    • , Tatiana M Foroud
    • , Jonathan L Haines
    • , Richard Mayeux
    • , Margaret A Pericak-Vance
    • , Lindsay A Farrer
    •  & Gerard D Schellenberg
  • Letter |

    Yardena Samuels and colleagues report the sequencing of 14 melanoma exomes. They identify a recurrent mutation in TRRAP in 4% of cases as well as mutations in GRIN2A in 33% of tumors.

    • Xiaomu Wei
    • , Vijay Walia
    • , Jimmy C Lin
    • , Jamie K Teer
    • , Todd D Prickett
    • , Jared Gartner
    • , Sean Davis
    • , NISC Comparative Sequencing Program
    • , Katherine Stemke-Hale
    • , Michael A Davies
    • , Jeffrey E Gershenwald
    • , William Robinson
    • , Steven Robinson
    • , Steven A Rosenberg
    •  & Yardena Samuels
  • Letter |

    Amanda Spurdle and colleagues report results of a genome-wide association study of endometrial cancer. They identify a risk variant near HNF1B that has previously been associated with increased risk of prostate cancer and with reduced risk of type 2 diabetes.

    • Amanda B Spurdle
    • , Deborah J Thompson
    • , Shahana Ahmed
    • , Kaltin Ferguson
    • , Catherine S Healey
    • , Tracy O'Mara
    • , Logan C Walker
    • , Stephen B Montgomery
    • , Emmanouil T Dermitzakis
    • , The Australian National Endometrial Cancer Study Group
    • , Paul Fahey
    • , Grant W Montgomery
    • , Penelope M Webb
    • , Peter A Fasching
    • , Matthias W Beckmann
    • , Arif B Ekici
    • , Alexander Hein
    • , Diether Lambrechts
    • , Lieve Coenegrachts
    • , Ignace Vergote
    • , Frederic Amant
    • , Helga B Salvesen
    • , Jone Trovik
    • , Tormund S Njolstad
    • , Harald Helland
    • , Rodney J Scott
    • , Katie Ashton
    • , Tony Proietto
    • , Geoffrey Otton
    • , National Study of Endometrial Cancer Genetics Group
    • , Ian Tomlinson
    • , Maggie Gorman
    • , Kimberley Howarth
    • , Shirley Hodgson
    • , Montserrat Garcia-Closas
    • , Nicolas Wentzensen
    • , Hannah Yang
    • , Stephen Chanock
    • , Per Hall
    • , Kamila Czene
    • , Jianjun Liu
    • , Jingmei Li
    • , Xiao-Ou Shu
    • , Wei Zheng
    • , Jirong Long
    • , Yong-Bing Xiang
    • , Mitul Shah
    • , Jonathan Morrison
    • , Kyriaki Michailidou
    • , Paul D Pharoah
    • , Alison M Dunning
    •  & Douglas F Easton
  • Letter |

    Koichi Matsuda and colleagues report a genome-wide association study for hepatitis C virus–induced hepatocellular carcinoma. They identify a susceptibility locus at MICA in individuals of Japanese ancestry.

    • Vinod Kumar
    • , Naoya Kato
    • , Yuji Urabe
    • , Atsushi Takahashi
    • , Ryosuke Muroyama
    • , Naoya Hosono
    • , Motoyuki Otsuka
    • , Ryosuke Tateishi
    • , Masao Omata
    • , Hidewaki Nakagawa
    • , Kazuhiko Koike
    • , Naoyuki Kamatani
    • , Michiaki Kubo
    • , Yusuke Nakamura
    •  & Koichi Matsuda
  • Letter |

    Eisei Noiri and colleagues show that intronic variants in GPC5 are associated with acquired nephrotic syndrome. They further show that knockdown of Gpc5 in mice confers resistance to podocyte injury in two different models of experimentally induced nephrosis.

    • Koji Okamoto
    • , Katsushi Tokunaga
    • , Kent Doi
    • , Toshiro Fujita
    • , Hodaka Suzuki
    • , Tetsuo Katoh
    • , Tsuyoshi Watanabe
    • , Nao Nishida
    • , Akihiko Mabuchi
    • , Atsushi Takahashi
    • , Michiaki Kubo
    • , Shiro Maeda
    • , Yusuke Nakamura
    •  & Eisei Noiri
  • Letter |

    Tatsuhiro Shibata and colleagues report the sequencing of a hepatocellular carcinoma. The authors identified 63 somatic non-synonymous substitutions and 22 somatic chromosomal rearrangements in this liver tumor.

    • Yasushi Totoki
    • , Kenji Tatsuno
    • , Shogo Yamamoto
    • , Yasuhito Arai
    • , Fumie Hosoda
    • , Shumpei Ishikawa
    • , Shuichi Tsutsumi
    • , Kohtaro Sonoda
    • , Hirohiko Totsuka
    • , Takuya Shirakihara
    • , Hiromi Sakamoto
    • , Linghua Wang
    • , Hidenori Ojima
    • , Kazuaki Shimada
    • , Tomoo Kosuge
    • , Takuji Okusaka
    • , Kazuto Kato
    • , Jun Kusuda
    • , Teruhiko Yoshida
    • , Hiroyuki Aburatani
    •  & Tatsuhiro Shibata
  • Letter |

    George Vassiliou, Allan Bradley and colleagues perform a Sleeping Beauty transposon mutagenesis screen to identify insertions that cooperate with mutant Npm1 to produce acute myeloid leukemia (AML) in mice. They observed mutually exclusive integrations in Csf2, Flt3 or Rasgrp1 in a high percentage of cases, providing insights into the molecular pathogenesis of this AML subtype.

    • George S Vassiliou
    • , Jonathan L Cooper
    • , Roland Rad
    • , Juan Li
    • , Stephen Rice
    • , Anthony Uren
    • , Lena Rad
    • , Peter Ellis
    • , Rob Andrews
    • , Ruby Banerjee
    • , Carolyn Grove
    • , Wei Wang
    • , Pentao Liu
    • , Penny Wright
    • , Mark Arends
    •  & Allan Bradley
  • Letter |

    Detlef Weigel and colleagues report the genome sequence of Arabidopsis lyrata. In comparison with the much smaller genome of A. thaliana, from which A. lyrata diverged about 10 million years ago, they find that the reduction in genome size is attributed to a large number of deletions across the genome.

    • Tina T Hu
    • , Pedro Pattyn
    • , Erica G Bakker
    • , Jun Cao
    • , Jan-Fang Cheng
    • , Richard M Clark
    • , Noah Fahlgren
    • , Jeffrey A Fawcett
    • , Jane Grimwood
    • , Heidrun Gundlach
    • , Georg Haberer
    • , Jesse D Hollister
    • , Stephan Ossowski
    • , Robert P Ottilar
    • , Asaf A Salamov
    • , Korbinian Schneeberger
    • , Manuel Spannagl
    • , Xi Wang
    • , Liang Yang
    • , Mikhail E Nasrallah
    • , Joy Bergelson
    • , James C Carrington
    • , Brandon S Gaut
    • , Jeremy Schmutz
    • , Klaus F X Mayer
    • , Yves Van de Peer
    • , Igor V Grigoriev
    • , Magnus Nordborg
    • , Detlef Weigel
    •  & Ya-Long Guo
  • Letter |

    Sarah Fortune and colleagues report the whole-genome sequencing of Mycobacterium tuberculosis strains isolated from cynomolgus macaques with either active, latent or early reactivation disease. They estimate a similar mutation rate for these disease states in vivo, as well as for the bacterium in vitro. This suggests that M. tuberculosis has a greater mutational rate during latent and early reactivation disease than previously predicted and may be able to acquire drug resistance during these states.

    • Christopher B Ford
    • , Philana Ling Lin
    • , Michael R Chase
    • , Rupal R Shah
    • , Oleg Iartchouk
    • , James Galagan
    • , Nilofar Mohaideen
    • , Thomas R Ioerger
    • , James C Sacchettini
    • , Marc Lipsitch
    • , JoAnne L Flynn
    •  & Sarah M Fortune
  • Letter |

    Sebastian Bonhoeffer, Christos Petropoulos and colleagues report a systems analysis of the fitness landscape of HIV-1 protease and reverse transcriptase. They use a dataset of over 70,000 virus samples, isolated from HIV-1 subtype B infected individuals, assayed for in vitro replicative capacity alone or under drug selection.

    • Trevor Hinkley
    • , João Martins
    • , Colombe Chappey
    • , Mojgan Haddad
    • , Eric Stawiski
    • , Jeannette M Whitcomb
    • , Christos J Petropoulos
    •  & Sebastian Bonhoeffer

Technical Report

  • Technical Report |

    Mark DePristo and colleagues report an analytical framework to discover and genotype variation using whole exome and genome resequencing data from next-generation sequencing technologies. They apply these methods to low-pass population sequencing data from the 1000 Genomes Project.

    • Mark A DePristo
    • , Eric Banks
    • , Ryan Poplin
    • , Kiran V Garimella
    • , Jared R Maguire
    • , Christopher Hartl
    • , Anthony A Philippakis
    • , Guillermo del Angel
    • , Manuel A Rivas
    • , Matt Hanna
    • , Aaron McKenna
    • , Tim J Fennell
    • , Andrew M Kernytsky
    • , Andrey Y Sivachenko
    • , Kristian Cibulskis
    • , Stacey B Gabriel
    • , David Altshuler
    •  & Mark J Daly

    Collection:

Corrigenda

  • Corrigendum |

    • Timothy R D J Radstake
    • , Olga Gorlova
    • , Blanca Rueda
    • , Jose-Ezequiel Martin
    • , Behrooz Z Alizadeh
    • , Rogelio Palomino-Morales
    • , Marieke J Coenen
    • , Madelon C Vonk
    • , Alexandre E Voskuyl
    • , Annemie J Schuerwegh
    • , Jasper C Broen
    • , Piet L C M van Riel
    • , Ruben van 't Slot
    • , Annet Italiaander
    • , Roel A Ophoff
    • , Gabriela Riemekasten
    • , Nico Hunzelmann
    • , Carmen P Simeon
    • , Norberto Ortego-Centeno
    • , Miguel A González-Gay
    • , María F González-Escribano
    • ,
    • , Paolo Airo
    • , Jaap van Laar
    • , Ariane Herrick
    • , Jane Worthington
    • , Roger Hesselstrand
    • , Vanessa Smith
    • , Filip de Keyser
    • , Fredric Houssiau
    • , Meng May Chee
    • , Rajan Madhok
    • , Paul Shiels
    • , Rene Westhovens
    • , Alexander Kreuter
    • , Hans Kiener
    • , Elfride de Baere
    • , Torsten Witte
    • , Leonid Padykov
    • , Lars Klareskog
    • , Lorenzo Beretta
    • , Rafaella Scorza
    • , Benedicte A Lie
    • , Anna-Maria Hoffmann-Vold
    • , Patricia Carreira
    • , John Varga
    • , Monique Hinchcliff
    • , Peter K Gregersen
    • , Annette T Lee
    • , Jun Ying
    • , Younghun Han
    • , Shih-Feng Weng
    • , Christopher I Amos
    • , Fredrick M Wigley
    • , Laura Hummers
    • , J Lee Nelson
    • , Sandeep K Agarwal
    • , Shervin Assassi
    • , Pravitt Gourh
    • , Filemon K Tan
    • , Bobby P C Koeleman
    • , Frank C Arnett
    • , Javier Martin
    •  & Maureen D Mayes
  • Corrigendum |

    • Erica E Davis
    • , Qi Zhang
    • , Qin Liu
    • , Bill H Diplas
    • , Lisa M Davey
    • , Jane Hartley
    • , Corinne Stoetzel
    • , Katarzyna Szymanska
    • , Gokul Ramaswami
    • , Clare V Logan
    • , Donna M Muzny
    • , Alice C Young
    • , David A Wheeler
    • , Pedro Cruz
    • , Margaret Morgan
    • , Lora R Lewis
    • , Praveen Cherukuri
    • , Baishali Maskeri
    • , Nancy F Hansen
    • , James C Mullikin
    • , Robert W Blakesley
    • , Gerard G Bouffard
    • ,
    • , Gabor Gyapay
    • , Susanne Rieger
    • , Burkhard Tönshoff
    • , Ilse Kern
    • , Neveen A Soliman
    • , Thomas J Neuhaus
    • , Kathryn J Swoboda
    • , Hulya Kayserili
    • , Tomas E Gallagher
    • , Richard A Lewis
    • , Carsten Bergmann
    • , Edgar A Otto
    • , Sophie Saunier
    • , Peter J Scambler
    • , Philip L Beales
    • , Joseph G Gleeson
    • , Eamonn R Maher
    • , Tania Attié-Bitach
    • , Hélène Dollfus
    • , Colin A Johnson
    • , Eric D Green
    • , Richard A Gibbs
    • , Friedhelm Hildebrandt
    • , Eric A Pierce
    •  & Nicholas Katsanis