Volume 26 Issue 3, November 2000

Volume 26 Issue 3

Cover art by Christine McCarthy

Editorial

News and Views

  • News & Views |

    The recognition of new Y-chromosome markers represents a major leap in the investigation of human genetic diversity (in male lineages, complementing the information from female lineages derived from mitochondrial DNA). The resulting phylogeny supports the out-of-Africa origins of our species and opens the way to further insights into prehistoric demography and world prehistory.

    • Colin Renfrew
    • , Peter Forster
    •  & Matthew Hurles
  • News & Views |

    Giant axonal neuropathy (GAN) is a recessive motor and sensory neuropathy of the central and peripheral nervous system. People with GAN show a distortion of nerve fibres due to axonal swellings caused by the accumulation of neurofilaments. A new study reports the cloning of the gene underlying GAN, whose protein product, gigaxonin, is a novel protein of the cytoskeleton and a member of the kelch-repeat superfamily.

    • Vincent Timmerman
    • , Peter De Jonghe
    •  & Christine Van Broeckhoven
  • News & Views |

    Nucleotide excision repair (NER) is a highly conserved multi-step process. Congenital NER defects are clinically complex, at least in part because components of the NER machinery also function in the basal transcription factor, TFIIH. A new study demonstrates that reduction in the amount, rather than the inherent activity, of TFIIH is the underlying cause of one such congenital NER defect, underscoring the link between transcription and NER-associated disease.

    • John H J Petrini
  • News & Views |

    The Mep ammonium transporters of Saccharomyces cerevisiae share amino acid sequence identity with the Rh blood group antigen proteins. A new study shows that the Rhg glycoproteins transport ammonium when heterologously expressed in mep mutant yeast cells, indicating a role for the Rh antigen complex.

    • Joseph Heitman
    •  & Peter Agre

Correspondence

Brief Communications

Progress

New Technology

Articles

Letters

Correction