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Accurate measurements of genomic copy number polymorphisms are required to define their medical relevance, but obtaining such measurements for multiallelic copy number variants has been challenging. A copy-number study of psoriasis now sets some useful precedents for a maturing field.
Primary cilia and planar cell polarity (PCP) proteins both contribute to cell polarization, but their relationship is unclear. A new study shows that, in the organ of Corti, primary cilia are required for morphological polarization of sensory hair cells and function downstream of the PCP signaling proteins.
