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Shigeru Chiba and colleagues report exome sequencing of angioimmunoblastic T cell lymphoma (AITL) and other peripheral T cell lymphomas and identify a recurrent somatic RHOA mutation encoding a p.Gly17Val alteration in 68% of AITL samples.
Peter Campbell, Mel Greaves and colleagues use exome and whole-genome sequencing to characterize somatic mutations in childhood acute lymphoblastic leukemias with the ETV6-RUNX1 fusion gene. They find that RAG-mediated deletions are the dominant mutational process.
Neil Hunter and colleagues show that the HEI10 ubiquitin ligase regulates meiotic recombination by limiting the colocalization of RNF212 and MSH4-MSH5 to future crossover sites. At later stages, they find that HEI10 accumulates stably at designated crossover sites and facilitates clearance of RNF212 and MSH4-MSH5 complexes to promote the final steps of meiotic recombination.
Gong-Hong Wei, Jussi Taipale and colleagues show that a prostate cancer risk allele at 6q22 enhances HOXB13 chromatin binding at this locus, leading to increased allele-specific expression of RFX6. They further show that RFX6 suppression reduces the proliferation, migration and invasion of prostate cancer cells and that RFX6 expression in clinical samples correlates with tumor progression and metastasis.