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A molecular variant of angiotensinogen associated with preeclampsia

Nature Genetics volume 4, pages 59–61 (1993)Cite this article

Abstract

Pregnancy–induced hypertension (PIH) is a heterogeneous disorder which complicates 5–7% of all pregnancies and remains a leading cause of maternal, fetal and neonatal morbidity and mortality. Severe preeclampsia is the most distinctive and life–threatening form; a multi–system disorder more common in first pregnancies, it is characterized by high blood pressure and proteinuria. In a series of Caucasian women with pregnancy–induced hypertension, we have observed a significant association of preeclampsia with a molecular variant of angiotensinogen, T235, found previously to be associated with essential hypertension. This finding is corroborated in a sample ascertained in Japan. Together, these observations support a new pathophysiological interpretation of preeclampsia and of its relation to some forms of essential hypertension.

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References

  1. Chesley, L.C. & Lindheimer, M.D. Renal hemodynamics and intravascular volume in normal and hypertensive pregnancy. In Handbook of Hypertension, Vol 10: Hypertension in Pregnancy (ed. Rubin P.C.) 38–65 (Elsevier, Amsterdam, 1988).

    Google Scholar 

  2. Wallenburg, H.C.S. Hemodynamics in hypertensive pregnancy. In Handbook of Hypertension, Vol 10: Hypertension in Pregnancy (ed. Rubin P.C.) 66–101 (Elsevier, Amsterdam, 1988).

    Google Scholar 

  3. August, P. & Sealey, J.E. The renin–angiotnesin system in normal and hypertensive pregnancy and in ovarian function. In Hypertension: Pathophysiology,Diagnosis, and Management (eds Laragh, J.H. & Brenner, B.M.) 1761–1778 (Raven, New York, 1990).

    Google Scholar 

  4. Lynch, K.R. & Peach, M.J. Biochemistry and molecular biology. Hypertension 17, 263–269 (1991).

    Article  CAS  Google Scholar 

  5. Tewksbury, D.A. Angiotensinogen: biochemistry and molecular biology. In Hypertension: Pathophysiology, Diagnosis, and Management (eds Laragh, J.H. & Brenner, B.M.) 1197–1216 (Raven, New York, 1990).

    Google Scholar 

  6. Tewksbury, D.A. & Dart, R.A. High molecular weight angiotensinogen levels in hypertensive pregnant women. Hypertension 4, 729–734 (1982).

    Article  CAS  Google Scholar 

  7. Gant, N.F., Whalley, P.J., Everett, R.B., Worley, R.J. & MacDonald, P.C. Control of vascular reactivity in pregnancy. Am. J. kidney Dis. 9, 303–307 (1987).

    Article  CAS  Google Scholar 

  8. Liston, W.A., & Kilpatrick, D.C. Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same signle recessive gene in mother and fetus? Br. J. Obstet. Gynecol. 98, 1079–1086 (1991).

    Article  CAS  Google Scholar 

  9. Cooper, D.W., Hill, J.A. & Chesley, L.C. Genetic control of susceptibility to eclampsia and miscarriage. Br. J. Obstet. Gynecol. 95, 644–653 (1988).

    Article  CAS  Google Scholar 

  10. Chesley, L.C., Annitto, J.E., & Cosgrove, R.A. The remote prognosis of eclamptic women. Am. J. Obstet. Gynecol. 124, 446–452 (1976).

    Article  CAS  Google Scholar 

  11. Fischer, K.A., Luger, L., Spargo, B.H. & Lindheimer, M.D. Hypertension in pregnancy: clinical pathologic correlations and remote prognosis. Medicine 60, 267–272 (1981).

    Article  Google Scholar 

  12. Gaillard, I., Clauser, E. & Corvol, P. Structure of human angiotensinogen gene. DNA 8, 87–99 (1989).

    Article  CAS  Google Scholar 

  13. Gaillard, I., Mattei, M.G., Clauser, E. & Corvol, P. Assignment by in situ hybrization of the angiotensinogen gene to chromosome band 1q4, the same region as the human renin gene. Hum. Genet. 84, 341–343 (1990).

    Google Scholar 

  14. Jeunemaitre, X. et al. Molecular basis of human hypertension: role of angiotensiongen. Cell 71, 169–180 (1992).

    Article  CAS  Google Scholar 

  15. Laragh, J.H. The pill, hypertension, and the toxemias of pregnancy. Am. J. Obstet. Gynecol. 109, 210–213 (1971).

    Article  CAS  Google Scholar 

  16. Schwartz, M.L. & Brenner, W.E. Pregnancy-induced hypertension presenting with life-threatening thrombocytopenia. Am. J. Obstet. Gynecol. 146, 756–761 (1983).

    Article  CAS  Google Scholar 

  17. Jacobson, C. in Utah in Demographic Perspective (eds Martin, T.K., Heaton, T.B. & Bahr, S.J.) 165–179 (Signature Press, New York).

  18. Taylor, D.J. The epidemiology of hypertension during pregnancy. In Handbook of Hypertension, Vol 10: Hypertension in Pregnancy (ed. Rubin P.C.) 223–240 (Elsevier, Amsterdam, 1988).

    Google Scholar 

  19. Musey, V.C. et al. Long term effects of a first pregnancy on the hormonal environment: estrogens and androgens. J. clin. Endocrin. Metab. 64, 111–118 (1987).

    Article  CAS  Google Scholar 

  20. Wang, D.Y. et al. The permanent effect of reproductive events on blood prolactin levels and its relation to breast cancer risk: a population study of postmenopausal women. Eur. J. Cancer clin. Oncol. 24, 1225–1231 (1988).

    Article  CAS  Google Scholar 

  21. American College of Obstetrics and Gynecology Pregnancy induced hypertension. Technical Bulletin, 91 (1986).

  22. Sibai, B.M. et al. Maternal-perinatal outcome associated with the syndrome of hemolysis elevated liver enzymes and low platelets in severe preeclampsia-eclampsia. Am. J. Obstet. Gynecol. 155, 501–506 (1986).

    Article  CAS  Google Scholar 

  23. Plouin, P.F., Chatellier, G., Guyenne, T.T., Vincent, N. & Corvol, P. Recent advances in the clinical study of the renin system. Reference values and conditions of validity. Presse Med. 18, 917–921 (1989).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah, 84132, USA

    K. Ward, L. Nelson & P. F. Farrington

  2. Department of Biochemistry, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, Japan

    A. Hata, C. Namikawa & M. Sasaki

  3. Howard Hughes Medical Institute and Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, 84112, USA

    X. Jeunemaitre, C. Helin, R.P. Lifton & J.-M. Lalouel

  4. Department of Hypertension, Broussais Hospital, 75014, Paris, France

    X. Jeunemaitre, S. Berrebi & P. Corvol

  5. Department of Obstetrics and Gynecology, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, Japan

    M. Ogasawara & K. Suzumori

  6. Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, 545, Japan

    S. Tomoda

  7. Endocrine-Hypertension Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    R.P. Lifton

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  1. K. Ward
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  4. C. Helin
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  5. L. Nelson
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  6. C. Namikawa
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  8. M. Ogasawara
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  10. S. Tomoda
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  11. S. Berrebi
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  12. M. Sasaki
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  13. P. Corvol
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  14. R.P. Lifton
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  15. J.-M. Lalouel
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Ward, K., Hata, A., Jeunemaitre, X. et al. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 4, 59–61 (1993). https://doi.org/10.1038/ng0593-59

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