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Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia

Journal of Human Hypertension volume 36, pages 271–279 (2022)Cite this article

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Abstract

Allelic variations affecting the activity of the maternal renin-angiotensin system may play a role in the development of hypertensive disorders of pregnancy like preeclampsia, its more severe early-onset form, and intrauterine growth restriction. We examined the association of common allelic variants of angiotensin II type 1 and type 2 receptor genes (AT1R and AT2R) sorted in five AT1R/AT2R receptor combination genotype groups with susceptibility to early-onset preeclampsia (EOP). The occurrence of AT1R (A1166C) and A2TR (C3123A) alleles in wild type (AA, CC), heterozygous (A/C, C/A), and homozygous (C/C, A/A) states was recorded in 84 women with a history of EOP and 84 age-matched controls sorted in five AT1R/AT2R receptor combination genotype (wild type: AA/CC, one mutant: AA/CA, AC/CC, two mutant: AC/CA, AA/AA, CC/CC, three mutants: AC/AA, CC/CA and four mutant: CC/AA) groups, by polymerase chain reaction-RFLP analysis. Three mutant receptor combination genotype carriers were more common in women with a history of EOP than in controls (26.18% vs. 4.76%, p = 0.003, OR = 8.25). Receptor combination genotyping may be of clinical value in: (a) maternal prediction of susceptibility to EOP, (b) disease subtyping for directed studies with receptor signaling antagonists, (c) the broader study of hypertension.

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Fig. 1: Logistic regression analysis for the association of AT1R/AT2R receptor combination genotype carriers with susceptibility to EOP.

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Authors and Affiliations

  1. Department of Biology, Faculty of Medicine, University of Thessaly, Larissa, Greece

    M. Satra, A. Baka, T.-M. Tsalazidou-Founta & N. Vamvakopoulos

  2. Department of Pathology, Faculty of Medicine, University of Thessaly, Larissa, Greece

    M. Samara

  3. Department of Biomedical Sciences, University of West Attica, Athens, Greece

    G. Alatsathianos

  4. A’ Neonatal Intensive Care Unit “Agia Sophia” Children’s Hospital, Athens, Greece

    D. Vamvakopoulou

  5. Cardiology Department, Papageorgiou General Hospital, Thessaloniki, Greece

    A. Sidiropoulos

  6. Department of Embryology, Faculty of Medicine, University of Thessaly, Larissa, Greece

    K.-O. Vamvakopoulos & S. Sotiriou

  7. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Thessaly, Larissa, Greece

    A. Garas & A. Daponte

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  1. M. Satra
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Correspondence to M. Satra.

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Satra, M., Samara, M., Alatsathianos, G. et al. Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia. J Hum Hypertens 36, 271–279 (2022). https://doi.org/10.1038/s41371-021-00524-5

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