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Maintaining stability in the face of change

How does the brain orchestrate the integration of new neurons into mature circuitry, without disrupting those circuits in the process? Mizrahi and Katz provide a new perspective on how the brain manages this dilemma, by showing that the dendritic backbone of mitral/tufted cells in the adult olfactory bulb is remarkably stable despite learning and neuron turnover.

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Figure 1: Imaging dynamics in the living olfactory bulb.

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Buttery, P., Mason, C. Maintaining stability in the face of change. Nat Neurosci 6, 1117–1119 (2003). https://doi.org/10.1038/nn1103-1117

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