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A method for parameterizing electrophysiological neural power spectra into periodic and aperiodic components is introduced, addressing limitations of common approaches. The method is validated in simulation and demonstrated on real data applications.
The authors present an edge-centric model of brain connectivity. Edge networks are stable across datasets, and their structure can be modulated by sensory input. When clustered, edge networks yield pervasively overlapping functional modules.
Kuan, Phelps, et al. used synchrotron X-ray imaging and deep learning to map dense neuronal wiring in fly and mouse tissue, enabling examination of individual cells and connectivity in circuits governing motor control and perceptual decision-making.
This study describes a series of new gene-regulatory sequences that restrict expression of viral transgenes to specific interneuron subtypes, allowing for selective monitoring and manipulation of their activity from mice to humans.
Garcia-Marques et al. present CLADES, an innovative approach to study neuronal lineages based on CRISPR. Inspired by synthetic biology, CLADES relies on a system of genetic switches to activate and inactivate reporter genes in a predetermined order.
SPARC is an all-genetic toolkit to express effectors in precise proportions of neurons. This method enables imaging of individual neurons and manipulation of neuronal subpopulations.
Deschloroclozapine (DCZ) is a broadly useful chemogenetic agonist for studies using nonhuman primates and mice. DCZ rapidly and reversibly activates DREADDs, and its binding can be visualized noninvasively by positron emission tomography.
Makin and colleagues decode speech from neural signals recorded during a preoperative procedure, using an algorithm inspired by machine translation. For one participant reading from a closed set of 50 sentences, decoding accuracy is nearly perfect.
Sey et al. report a computational tool, H-MAGMA, that extracts neurobiological insights from brain-disorder GWAS by linking risk variants to their cognate genes using chromatin interaction profiles from human brain tissue.
A chemogenetic approach was developed for cell-type-specific drug-inducible protein synthesis inhibition in mice. It was used to show that consolidation of long-term aversive memories requires rapid neuronal protein synthesis in the amygdala.