Reviews & Analysis

Quantum-mechanical tunnelling currents across nanometre-scale gaps between electrodes are sensitive to the medium in the gap. Albrecht reviews progress towards using tunnelling currents to probe single-molecule processes, and in biosensor and sequencing applications.

High-valent iron–oxo and –nitrido complexes are intermediates in the catalytic cycles of various metalloenzymes that activate dioxygen and dinitrogen. Hohenbergeret al. review the advances in the chemistry of model high-valent iron–oxo and –nitrido systems and relate them to our understanding of related enzymes.

Hair cells of the inner ear transduce vibrations of the basilar membrane into electrical signals by a process known as mechanotransduction. Recent advances in genetic and molecular tools have led to an improved understanding of mechanotransduction as Peng and colleagues summarize in this Review.

Coarse-grained models can be used to study the folding of biological macromolecules such as DNA, RNA and proteins. In this Review, Hyeon and Thirumalai describe recent advances in the use of these theoretical models to describe dynamic processes in biology.

Type Ia supernovae are thought to result from the explosion of white dwarf stars but a full understanding of their formation is lacking. In this review, Howell describes how large surveys are generating sufficient data to challenge and refine existing theories.

Biofouling, or the unwanted growth of biological organisms, is a particular problem in marine environments. This review considers recent advances in the development of environmentally friendly coatings to combat biofouling of submerged surfaces.

Gravitational waves are predicted by general relativity, but their direct observation from astronomical sources hinges on large improvements in detection sensitivity. The authors review how squeezed light and other quantum optical concepts are being applied in the development of next generation interferometric detectors.

Biologically active molecules can be identified through the screening of small-molecule libraries, but compound collections typically consist of large numbers of structurally similar compounds. Gallowayet al. review how diversity-oriented synthesis can efficiently generate structurally diverse compound libraries.

Many of the worlds' plants and trees have a symbiotic relationship with micorrhizal fungi, which associate with their roots. This review describes how new technologies have aided our understanding of the mechanisms that regulate these plant–fungi interactions.