Browse Articles

Filter By:

  • The common ancestor of all living arthropods had biramous postantennal appendages, with an endopodite and exopodite branching off the limb base. This study uses microtomographic imaging of the Cambrian arthropod Leanchoilia to reveal a previously undetected exite at the base of most appendages, suggesting a deeper origin for exites in arthropod phylogeny.

    • Yu Liu
    • Gregory D. Edgecombe
    • Xianguang Hou
    Article Open Access
  • Semiconductor surface states often stand in the way of device performance, but here, the authors take advantage of them for wavelength conversion. They present a compact, passive conversion device insensitive to optical alignment by using plasmon-coupled surface states that enable the efficient conversion without nonlinear phenomena.

    • Deniz Turan
    • Ping Keng Lu
    • Mona Jarrahi
    Article Open Access
  • Catalytic amide bond-forming methods is important because they could potentially address the existing limitations of classical methods using superstoichiometric activating reagents. Here the authors show an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by FeI2, P(V)/P(III) and photoredox catalysis that avoids the production of byproducts.

    • Yunyun Ning
    • Shuaishuai Wang
    • Jin Xie
    Article Open Access
  • Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that has caused outbreaks in various regions of the world. Here the authors present safety and immunogenicity data from a phase 1 trial with the simian adenovirus vectored vaccine ChAdOx1 Chik, showing induction of neutralizing antibodies to four CHIKV lineages.

    • Pedro M. Folegatti
    • Kate Harrison
    • Arturo Reyes-Sandoval
    Article Open Access
  • To understand malaria symptoms, several studies investigate association between parasite’s transcriptome and disease severity. Here, Thomson-Luque et al. reanalyze available transcriptomic data of P. falciparum and find that longer circulation of infected erythrocytes without sequestering to endothelial cells associates with decreasing parasitaemia and less severe disease.

    • Richard Thomson-Luque
    • Lasse Votborg-Novél
    • Silvia Portugal
    Article Open Access
  • Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, maintaining genomic stability and tumour growth.

    • Virginia Giuliani
    • Meredith A. Miller
    • Timothy P. Heffernan
    Article Open Access
  • Understanding correlations between molecular structures and macroscopic properties is critical in realising highly efficient organic photovoltaics. Here, the authors conduct a comprehensive study based on four non-fullerene acceptors revealing how the extended conjugation, asymmetric terminals and alkyl chain length can affect device performance.

    • Shuixing Li
    • Lingling Zhan
    • Hongzheng Chen
    Article Open Access
  • Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ribosome and EF-G to induce +1 frameshifting during the translocation step.

    • Gabriel Demo
    • Howard B. Gamper
    • Andrei A. Korostelev
    Article Open Access
  • Silica formation in diatoms is of interest for a range of different subjects from biomimetics to oceanography. Here the authors study the formation of silicified extensions in diatoms and find that unlike cell wall elements, that form in the cytoplasm, the extensions have a different formation mechanism outside the cytoplasm.

    • Boaz Mayzel
    • Lior Aram
    • Assaf Gal
    Article Open Access
  • In their supercritical state simple fluids are generally thought to assume a homogeneous phase throughout. Lee et al. find that liquid droplets temporarily formed in a supercritical background after sub-critical injection can survive for a surprisingly long time.

    • Seungtaek Lee
    • Juho Lee
    • Gunsu Yun
    Article Open Access
  • Little is known about viral-host interactions in the continental subsurface. Here, the authors use a combination of metagenomics, fluorescence in situ hybridization, and electron microscopy to show infections of abundant C-fixing subsurface archaea by lytic viruses.

    • Janina Rahlff
    • Victoria Turzynski
    • Alexander J. Probst
    Article Open Access
  • Bacteria can secrete diffusible protein toxins that kill competing bacteria. Here, the authors use biochemical, biophysical and structural analyses to show how one of these toxins exploits TolC (a major antibiotic efflux channel) to transport itself across the outer membrane of target cells.

    • Nicholas G. Housden
    • Melissa N. Webby
    • Colin Kleanthous
    Article Open Access
  • The identification of catalytically active sites with atomic-scale precision occupies a central place in the theory and practice of heterogeneous catalysis. Here the authors assess the nature of the copper-oxygen bond in a Cu-CHA zeolite and recover the microscopic structure of single-metal sites.

    • Paolo Cleto Bruzzese
    • Enrico Salvadori
    • Mario Chiesa
    Article Open Access
  • Making a decision requires one to differentiate between choice options, committing to one and leaving the other behind. Here, the authors show that decision-making paradoxically binds options together, such that the outcome of the choice ends up changing the value of both the chosen and the unchosen options, in opposite directions.

    • Natalie Biderman
    • Daphna Shohamy
    Article Open Access
  • The antiferromagnetic topological insulator MnBi2Te4 exhibits Chern and axion insulator phases at low magnetic field; however, its behaviour in high magnetic field has remained unexplored. Here, using transport measurements at high magnetic field, the authors report a zero Hall plateau composed of two counter-propagating edge channels.

    • Chang Liu
    • Yongchao Wang
    • Yayu Wang
    Article Open Access