Browse Articles

  • Article
    | Open Access

    Here, the authors synthesize a variety of ultra-thin III–V single crystals, ranging from ultra-narrow to wide bandgap semiconductors, through enhancing the interfacial interaction between the III–V crystals and the growth substrates.

    • Yunxu Chen
    • , Jinxin Liu
    • , Mengqi Zeng
    • , Fangyun Lu
    • , Tianrui Lv
    • , Yuan Chang
    • , Haihui Lan
    • , Bin Wei
    • , Rong Sun
    • , Junfeng Gao
    • , Zhongchang Wang
    •  & Lei Fu
  • Article
    | Open Access

    Zinc affinity plays a key role in the zinc plating and stripping processes but its internal mechanism is still unclear. Here, the authors report a protective layer with controllable zinc affinity by adjusting the crystal orientation to suppress the dendrite growth on the zinc anode interface.

    • Qi Zhang
    • , Jingyi Luan
    • , Xiaobing Huang
    • , Qi Wang
    • , Dan Sun
    • , Yougen Tang
    • , Xiaobo Ji
    •  & Haiyan Wang
  • Article
    | Open Access

    Quintulene, a quintuple non-graphitic cycloarene, is challenging to synthesize. Here, the authors synthesize and characterize the cone-shaped extended quintulene and its bilayer dimer, and disclose its dimerization as an entropy-driven, second-order reaction with a substantial activation energy.

    • Hao Hou
    • , Xin-Jing Zhao
    • , Chun Tang
    • , Yang-Yang Ju
    • , Ze-Ying Deng
    • , Xin-Rong Wang
    • , Liu-Bin Feng
    • , Dong-Hai Lin
    • , Xu Hou
    • , Akimitsu Narita
    • , Klaus Müllen
    •  & Yuan-Zhi Tan
  • Article
    | Open Access

    Although knots in complex optical fields have been realized experimentally, the realization of acoustic vortex knots is still problematic. Here, the authors have demonstrated the creation of acoustic vortex knots by embedding the knot function into a propagating acoustic field using a metasurface hologram.

    • Hongkuan Zhang
    • , Weixuan Zhang
    • , Yunhong Liao
    • , Xiaoming Zhou
    • , Junfei Li
    • , Gengkai Hu
    •  & Xiangdong Zhang
  • Article
    | Open Access

    Magnetic reconnection is a fundamental plasma process of magnetic energy conversion to kinetic energy. Here, the authors show direct evidence of secondary reconnection in the filamentary currents within the flux ropes indicating a significant contribution to energy conversion in the kinetic scale during turbulent reconnection.

    • Shimou Wang
    • , Rongsheng Wang
    • , Quanming Lu
    • , Huishan Fu
    •  & Shui Wang
  • Article
    | Open Access

    For advanced microcomb applications, the exact detection of the high repetition rate becomes difficult due to the limited bandwidth of the photodiodes. Here, the authors present a Vernier dual-comb method to sample the main soliton comb and divide the repetition rate by a generating low frequency beat notes.

    • Beichen Wang
    • , Zijiao Yang
    • , Xiaobao Zhang
    •  & Xu Yi
  • Article
    | Open Access

    Designing high-performance and energy efficient neural network hardware remains a challenge. Here, the authors develop a van der Waals hybrid synaptic device that features linear and symmetric conductance-update characteristics and demonstrate the feasibility for hardware neural network performing acoustic pattern recognition.

    • Seunghwan Seo
    • , Beom-Seok Kang
    • , Je-Jun Lee
    • , Hyo-Jun Ryu
    • , Sungjun Kim
    • , Hyeongjun Kim
    • , Seyong Oh
    • , Jaewoo Shim
    • , Keun Heo
    • , Saeroonter Oh
    •  & Jin-Hong Park
  • Article
    | Open Access

    Ocean cold seeps are poorly understood relative to related systems like hydrothermal vents. Here the authors use high pressure bioreactors and microbial communities from a cold seep mud volcano and find a previously missing step of methane conversion to acetate that likely fuels heterotrophic communities.

    • Shanshan Yang
    • , Yongxin Lv
    • , Xipeng Liu
    • , Yinzhao Wang
    • , Qilian Fan
    • , Zhifeng Yang
    • , Nico Boon
    • , Fengping Wang
    • , Xiang Xiao
    •  & Yu Zhang
  • Article
    | Open Access

    Diagnosing a heart attack requires excessive testing and prolonged observation, which frequently requires hospital admission. Here the authors report a machine learning-based system based exclusively on ECG data that can help clinicians identify 37% more heart attacks during initial screening.

    • Salah Al-Zaiti
    • , Lucas Besomi
    • , Zeineb Bouzid
    • , Ziad Faramand
    • , Stephanie Frisch
    • , Christian Martin-Gill
    • , Richard Gregg
    • , Samir Saba
    • , Clifton Callaway
    •  & Ervin Sejdić
  • Article
    | Open Access

    Heavy metals and metalloids pose major threats to health and environmental ecosystems, thus systems for low-cost remediation are needed. Here the authors report the scalable design of a hydrogen-bonded organic–inorganic framework for selective removal of trace heavy metal ions from water.

    • Ngoc T. Bui
    • , Hyungmook Kang
    • , Simon J. Teat
    • , Gregory M. Su
    • , Chih-Wen Pao
    • , Yi-Sheng Liu
    • , Edmond W. Zaia
    • , Jinghua Guo
    • , Jeng-Lung Chen
    • , Katie R. Meihaus
    • , Chaochao Dun
    • , Tracy M. Mattox
    • , Jeffrey R. Long
    • , Peter Fiske
    • , Robert Kostecki
    •  & Jeffrey J. Urban
  • Article
    | Open Access

    Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into monolayer lipid droplets (LDs), but how proteins partition between ER and LDs is poorly understood. Here authors use synthetic model systems and find that proteins containing hydrophobic membrane association domains strongly prefer monolayers and that returning to the bilayer is unfavorable.

    • Lucie Caillon
    • , Vincent Nieto
    • , Pauline Gehan
    • , Mohyeddine Omrane
    • , Nicolas Rodriguez
    • , Luca Monticelli
    •  & Abdou Rachid Thiam
  • Article
    | Open Access

    Eukaryotic replisomes are multiprotein complexes. Here the authors reveal two distinct stressed replisomes, associated with DONSON and FANCM, displaying a bias in replication timing and chromatin domain.

    • Jing Zhang
    • , Marina A. Bellani
    • , Ryan C. James
    • , Durga Pokharel
    • , Yongqing Zhang
    • , John J. Reynolds
    • , Gavin S. McNee
    • , Andrew P. Jackson
    • , Grant S. Stewart
    •  & Michael M. Seidman
  • Article
    | Open Access

    Thalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.

    • Yiheng Tu
    • , Zening Fu
    • , Cuiping Mao
    • , Maryam Falahpour
    • , Randy L. Gollub
    • , Joel Park
    • , Georgia Wilson
    • , Vitaly Napadow
    • , Jessica Gerber
    • , Suk-Tak Chan
    • , Robert R. Edwards
    • , Ted J. Kaptchuk
    • , Thomas Liu
    • , Vince Calhoun
    • , Bruce Rosen
    •  & Jian Kong
  • Article
    | Open Access

    Wing touching induces a defensive response in D. melanogaster. Here, the authors show that female flies change the defensive response during courtship and after mating. This switch is mediated by functional reconfiguration of a neural circuit in the ventral nerve cord.

    • Chenxi Liu
    • , Bei Zhang
    • , Liwei Zhang
    • , Tingting Yang
    • , Zhewei Zhang
    • , Zihua Gao
    •  & Wei Zhang
  • Article
    | Open Access

    Small molecule stabilizers of protein–protein interactions hold great therapeutic potential. Based on virtual screening and molecular docking, the authors here develop a strategy to evolve weak, promiscuous inhibitors of 14-3-3 interactions into selective stabilizers of the 14-3-3/ChREBP complex.

    • Eline Sijbesma
    • , Emira Visser
    • , Kathrin Plitzko
    • , Philipp Thiel
    • , Lech-Gustav Milroy
    • , Markus Kaiser
    • , Luc Brunsveld
    •  & Christian Ottmann
  • Article
    | Open Access

    Terpene cyclases catalyze the formation of diverse hydrocarbon scaffolds found in terpenoids. Here, the authors report the cryptic function of class I terpene cyclases as aromatic prenyltransferases and the universality of this cryptic feature is confirmed using enzymes from different sources.

    • Haibing He
    • , Guangkai Bian
    • , Corey J. Herbst-Gervasoni
    • , Takahiro Mori
    • , Stephen A. Shinsky
    • , Anwei Hou
    • , Xin Mu
    • , Minjian Huang
    • , Shu Cheng
    • , Zixin Deng
    • , David W. Christianson
    • , Ikuro Abe
    •  & Tiangang Liu
  • Article
    | Open Access

    Dealloying usually relies on chemical dissolution of an alloy component. By contrast, the authors demonstrate an atomic-scale phase separation process that differs completely from the chemical dealloying mechanism and thus represents a significant departure from the well-known Hume-Rothery rules.

    • Lianfeng Zou
    • , Penghui Cao
    • , Yinkai Lei
    • , Dmitri Zakharov
    • , Xianhu Sun
    • , Stephen D. House
    • , Langli Luo
    • , Jonathan Li
    • , Yang Yang
    • , Qiyue Yin
    • , Xiaobo Chen
    • , Chaoran Li
    • , Hailang Qin
    • , Eric A. Stach
    • , Judith C. Yang
    • , Guofeng Wang
    •  & Guangwen Zhou
  • Article
    | Open Access

    Dedifferentiation state has been associated with therapy resistance in melanoma. Here, the authors uncover a pre-existing NGFR-expressing, targetable subpopulation that is resistant to immunotherapy and other treatments in melanoma cells and preclinical models.

    • Julia Boshuizen
    • , David W. Vredevoogd
    • , Oscar Krijgsman
    • , Maarten A. Ligtenberg
    • , Stephanie Blankenstein
    • , Beaunelle de Bruijn
    • , Dennie T. Frederick
    • , Juliana C. N. Kenski
    • , Mara Parren
    • , Marieke Brüggemann
    • , Max F. Madu
    • , Elisa A. Rozeman
    • , Ji-Ying Song
    • , Hugo M. Horlings
    • , Christian U. Blank
    • , Alexander C. J. van Akkooi
    • , Keith T. Flaherty
    • , Genevieve M. Boland
    •  & Daniel S. Peeper
  • Article
    | Open Access

    Bacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation.

    • Rafael Núñez-Ramírez
    • , Juanjo Huesa
    • , Yolanda Bel
    • , Juan Ferré
    • , Patricia Casino
    •  & Ernesto Arias-Palomo
  • Article
    | Open Access

    Although our lives are continuous, we perceive and remember experiences as discrete events. Here, the authors show that neural responses at event boundaries in the hippocampus and Posterior Medial cortical network decline as we age, and predict memory for narrative events.

    • Zachariah M. Reagh
    • , Angelique I. Delarazan
    • , Alexander Garber
    •  & Charan Ranganath
  • Article
    | Open Access

    Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre.

    • Wei Zhou
    • , Ben Brumpton
    • , Omer Kabil
    • , Julius Gudmundsson
    • , Gudmar Thorleifsson
    • , Josh Weinstock
    • , Matthew Zawistowski
    • , Jonas B. Nielsen
    • , Layal Chaker
    • , Marco Medici
    • , Alexander Teumer
    • , Silvia Naitza
    • , Serena Sanna
    • , Ulla T. Schultheiss
    • , Anne Cappola
    • , Juha Karjalainen
    • , Mitja Kurki
    • , Morgan Oneka
    • , Peter Taylor
    • , Lars G. Fritsche
    • , Sarah E. Graham
    • , Brooke N. Wolford
    • , William Overton
    • , Humaira Rasheed
    • , Eirin B. Haug
    • , Maiken E. Gabrielsen
    • , Anne Heidi Skogholt
    • , Ida Surakka
    • , George Davey Smith
    • , Anita Pandit
    • , Tanmoy Roychowdhury
    • , Whitney E. Hornsby
    • , Jon G. Jonasson
    • , Leigha Senter
    • , Sandya Liyanarachchi
    • , Matthew D. Ringel
    • , Li Xu
    • , Lambertus A. Kiemeney
    • , Huiling He
    • , Romana T. Netea-Maier
    • , Jose I. Mayordomo
    • , Theo S. Plantinga
    • , Jon Hrafnkelsson
    • , Hannes Hjartarson
    • , Erich M. Sturgis
    • , Aarno Palotie
    • , Mark Daly
    • , Cintia E. Citterio
    • , Peter Arvan
    • , Chad M. Brummett
    • , Michael Boehnke
    • , Albert de la Chapelle
    • , Kari Stefansson
    • , Kristian Hveem
    • , Cristen J. Willer
    •  & Bjørn Olav Åsvold
  • Article
    | Open Access

    Here, the authors use in situ transmission electron microscopy to measure the interface properties of electrical contacts with MoS2, ReS2, and graphene, and find that direct quantum tunnelling across van-der-Waals-bonded interfaces is more favourable than Fowler–Nordheim tunnelling across chemically bonded interfaces.

    • Lok-Wing Wong
    • , Lingli Huang
    • , Fangyuan Zheng
    • , Quoc Huy Thi
    • , Jiong Zhao
    • , Qingming Deng
    •  & Thuc Hue Ly
  • Article
    | Open Access

    The authors provide a comprehensive characterization of the human antibody response to a licensed hepatitis E virus (HEV) vaccine, Hecolin, in four individuals over the course of six months post vaccination. They demonstrate diverse patterns of antibody response underlying the vaccine protection.

    • Gui-Ping Wen
    • , Linling He
    • , Zi-Min Tang
    • , Si-Ling Wang
    • , Xu Zhang
    • , Yuan-Zhi Chen
    • , Xiaohe Lin
    • , Chang Liu
    • , Jia-Xin Chen
    • , Dong Ying
    • , Zi-Hao Chen
    • , Ying-Bin Wang
    • , Wen-Xin Luo
    • , Shou-Jie Huang
    • , Shao-Wei Li
    • , Jun Zhang
    • , Zi-Zheng Zheng
    • , Jiang Zhu
    •  & Ning-Shao Xia
  • Article
    | Open Access

    Light-driven heating of plasmonic metal nanoparticles can activate temperature-sensitive reactions at the nanoscale. Here, the authors exploit such nanoscale plasmonic reactors to drive, control, and spectroscopically track the growth of single metal@semiconductor core@shell nanoparticles.

    • Rifat Kamarudheen
    • , Gayatri Kumari
    •  & Andrea Baldi
  • Article
    | Open Access

    Inhibition in spinal nociceptive pathways is weaker and more labile in lamina I —where thermal input is primarily processed— than in lamina II that encodes predominantly high threshold mechanical input. This explains why noxious thermal input makes spinal circuits prone to catastrophic sensitization.

    • Francesco Ferrini
    • , Jimena Perez-Sanchez
    • , Samuel Ferland
    • , Louis-Etienne Lorenzo
    • , Antoine G. Godin
    • , Isabel Plasencia-Fernandez
    • , Martin Cottet
    • , Annie Castonguay
    • , Feng Wang
    • , Chiara Salio
    • , Nicolas Doyon
    • , Adalberto Merighi
    •  & Yves De Koninck
  • Article
    | Open Access

    We can flexibly coordinate our movements with external stimuli, but no circuit-level model exists to explain this ability. Inspired by fundamental concepts in control theory, the authors construct a modular neural circuit that captures human behavior in a wide range of temporal coordination tasks.

    • Seth W. Egger
    • , Nhat M. Le
    •  & Mehrdad Jazayeri
  • Article
    | Open Access

    Endothelial cell (EC) dysfunction and inflammation contribute to plaque destabilization in atherosclerosis, increasing the risk of thrombotic events. Here, the authors show that epsin promotes EC inflammation via a mechanism involving IP3R1 degradation, and that deletion of epsin in the endothelium prevents EC dysfunctoin and atherosclerosis in mice.

    • Yunzhou Dong
    • , Yang Lee
    • , Kui Cui
    • , Ming He
    • , Beibei Wang
    • , Sudarshan Bhattacharjee
    • , Bo Zhu
    • , Tadayuki Yago
    • , Kun Zhang
    • , Lin Deng
    • , Kunfu Ouyang
    • , Aiyun Wen
    • , Douglas B. Cowan
    • , Kai Song
    • , Lili Yu
    • , Megan L. Brophy
    • , Xiaolei Liu
    • , Jill Wylie-Sears
    • , Hao Wu
    • , Scott Wong
    • , Guanglin Cui
    • , Yusuke Kawashima
    • , Hiroyuki Matsumoto
    • , Yoshio Kodera
    • , Richard J. H. Wojcikiewicz
    • , Sanjay Srivastava
    • , Joyce Bischoff
    • , Da-Zhi Wang
    • , Klaus Ley
    •  & Hong Chen
  • Article
    | Open Access

    Y6, as a non-fullerene acceptor for organic solar cells, has attracted intensive attention because of the low voltage loss and high charge generation efficiency. Here, Zhang et al. find that the delocalization of exciton and electron wavefunction due to strong π-π packing of Y6 is the key for the high performance.

    • Guichuan Zhang
    • , Xian-Kai Chen
    • , Jingyang Xiao
    • , Philip C. Y. Chow
    • , Minrun Ren
    • , Grit Kupgan
    • , Xuechen Jiao
    • , Christopher C. S. Chan
    • , Xiaoyan Du
    • , Ruoxi Xia
    • , Ziming Chen
    • , Jun Yuan
    • , Yunqiang Zhang
    • , Shoufeng Zhang
    • , Yidan Liu
    • , Yingping Zou
    • , He Yan
    • , Kam Sing Wong
    • , Veaceslav Coropceanu
    • , Ning Li
    • , Christoph J. Brabec
    • , Jean-Luc Bredas
    • , Hin-Lap Yip
    •  & Yong Cao
  • Article
    | Open Access

    Frontal top-down cortical neurons implement top-down attentional control of sensory regions. The authors reveal adolescence as a developmental stage when frontal top-down neurons projecting from the anterior cingulate to visual cortex are functionally integrated into local excitatory circuitry.

    • Elisa M. Nabel
    • , Yury Garkun
    • , Hiroyuki Koike
    • , Masato Sadahiro
    • , Ana Liang
    • , Kevin J. Norman
    • , Giulia Taccheri
    • , Michael P. Demars
    • , Susanna Im
    • , Keaven Caro
    • , Sarah Lopez
    • , Julia Bateh
    • , Patrick R. Hof
    • , Roger L. Clem
    •  & Hirofumi Morishita
  • Article
    | Open Access

    The authors here present a deep learning model that simultaneously detects earthquake signals and measures seismic-phase arrival times. The model performs particularly well for cases with high background noise and the challenging task of picking the S wave arrival.

    • S. Mostafa Mousavi
    • , William L. Ellsworth
    • , Weiqiang Zhu
    • , Lindsay Y. Chuang
    •  & Gregory C. Beroza
  • Article
    | Open Access

    It is unclear if rates of autism and other neurodevelopmental and psychiatric diagnoses are elevated in transgender and gender-diverse individuals compared to cisgender individuals. Here, the authors use data from five different large-scale datasets to identify elevated rates of autism diagnoses, diagnoses of other neurodevelopmental and psychiatric conditions, and elevated traits related to autism in transgender and gender-diverse individuals, compared to cisgender individuals.

    • Varun Warrier
    • , David M. Greenberg
    • , Elizabeth Weir
    • , Clara Buckingham
    • , Paula Smith
    • , Meng-Chuan Lai
    • , Carrie Allison
    •  & Simon Baron-Cohen
  • Article
    | Open Access

    p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essential for tumor growth and metastasis.

    • Valeria Capaci
    • , Lorenzo Bascetta
    • , Marco Fantuz
    • , Galina V. Beznoussenko
    • , Roberta Sommaggio
    • , Valeria Cancila
    • , Andrea Bisso
    • , Elena Campaner
    • , Alexander A. Mironov
    • , Jacek R. Wiśniewski
    • , Luisa Ulloa Severino
    • , Denis Scaini
    • , Fleur Bossi
    • , Jodi Lees
    • , Noa Alon
    • , Ledia Brunga
    • , David Malkin
    • , Silvano Piazza
    • , Licio Collavin
    • , Antonio Rosato
    • , Silvio Bicciato
    • , Claudio Tripodo
    • , Fiamma Mantovani
    •  & Giannino Del Sal
  • Article
    | Open Access

    Monodisperse and well-defined self-assembled materials can be obtained by fuel-driven temporally controlled supramolecular polymerization via the buffered release of monomers. Here the authors show that a redox-responsive transient dormant state of monomer generated by redox reaction can lead to supramolecular polymers with low dispersity.

    • Krishnendu Jalani
    • , Anjali Devi Das
    • , Ranjan Sasmal
    • , Sarit S. Agasti
    •  & Subi J. George
  • Article
    | Open Access

    To investigate the molecular foundation of sporadic Alzheimer’s disease (AD), Beckmann et al. constructed multiscale causal networks on a large human AD multi-omics dataset, detecting AD-associated networks and their top predicted regulator, VGF, with extensive validation in the 5xFAD mouse model.

    • Noam D. Beckmann
    • , Wei-Jye Lin
    • , Minghui Wang
    • , Ariella T. Cohain
    • , Alexander W. Charney
    • , Pei Wang
    • , Weiping Ma
    • , Ying-Chih Wang
    • , Cheng Jiang
    • , Mickael Audrain
    • , Phillip H. Comella
    • , Amanda K. Fakira
    • , Siddharth P. Hariharan
    • , Gillian M. Belbin
    • , Kiran Girdhar
    • , Allan I. Levey
    • , Nicholas T. Seyfried
    • , Eric B. Dammer
    • , Duc Duong
    • , James J. Lah
    • , Jean-Vianney Haure-Mirande
    • , Ben Shackleton
    • , Tomas Fanutza
    • , Robert Blitzer
    • , Eimear Kenny
    • , Jun Zhu
    • , Vahram Haroutunian
    • , Pavel Katsel
    • , Sam Gandy
    • , Zhidong Tu
    • , Michelle E. Ehrlich
    • , Bin Zhang
    • , Stephen R. Salton
    •  & Eric E. Schadt
  • Article
    | Open Access

    Some bacterial lineages appear to be pre-disposed to evolving antibiotic resistance. Here, the authors show that differential expression of an efflux pump causes widespread variation in evolvability across Staphylococcus aureus isolates, and chemical inhibition of the pump prevents resistance evolution.

    • Andrei Papkou
    • , Jessica Hedge
    • , Natalia Kapel
    • , Bernadette Young
    •  & R. Craig MacLean
  • Article
    | Open Access

    Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from Alzheimer’s disease patients and healthy controls.

    • Penny J. Norsworthy
    • , Andrew G. B. Thompson
    • , Tze H. Mok
    • , Fernando Guntoro
    • , Luke C. Dabin
    • , Akin Nihat
    • , Ross W. Paterson
    • , Jonathan M. Schott
    • , John Collinge
    • , Simon Mead
    •  & Emmanuelle A. Viré
  • Article
    | Open Access

    While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops that are more toxic to the cell by causing DNA damage.

    • Alexy Promonet
    • , Ismaël Padioleau
    • , Yaqun Liu
    • , Lionel Sanz
    • , Anna Biernacka
    • , Anne-Lyne Schmitz
    • , Magdalena Skrzypczak
    • , Amélie Sarrazin
    • , Clément Mettling
    • , Maga Rowicka
    • , Krzysztof Ginalski
    • , Frédéric Chedin
    • , Chun-Long Chen
    • , Yea-Lih Lin
    •  & Philippe Pasero
  • Article
    | Open Access

    Genotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubiquitination, K48-linked polyubiquitination, and proteasomal degradation of β-catenin.

    • Wei Wang
    • , Mingqi Li
    • , Suriyan Ponnusamy
    • , Yayun Chi
    • , Jingyan Xue
    • , Beshoy Fahmy
    • , Meiyun Fan
    • , Gustavo A. Miranda-Carboni
    • , Ramesh Narayanan
    • , Jiong Wu
    •  & Zhao-Hui Wu
  • Article
    | Open Access

    While mass spectrometry-based proteomics largely relies on digesting proteins into peptides, there is no equivalent strategy for polysaccharide analysis. Here, the authors develop a chemical approach to break down poly- into oligosaccharides and present a workflow to identify polysaccharides by oligosaccharide fingerprinting.

    • Matthew J. Amicucci
    • , Eshani Nandita
    • , Ace G. Galermo
    • , Juan Jose Castillo
    • , Siyu Chen
    • , Dayoung Park
    • , Jennifer T. Smilowitz
    • , J. Bruce German
    • , David A. Mills
    •  & Carlito B. Lebrilla
  • Article
    | Open Access

    The allocation of remaining fossil fuel production has stimulated a discussion around issues of equitable allocation but the implications of different options are unclear. Here the authors show that shifting production to low-medium human development regions has limited economic benefits under strong climate policy.

    • Steve Pye
    • , Siân Bradley
    • , Nick Hughes
    • , James Price
    • , Daniel Welsby
    •  & Paul Ekins
  • Article
    | Open Access

    The authors here tackle the problem that too much seismic data is acquired worldwide to be evaluated in a timely fashion. Seydoux and colleagues develop a machine learning framework that can detect and cluster seismic signals in continuous seismic records.

    • Léonard Seydoux
    • , Randall Balestriero
    • , Piero Poli
    • , Maarten de Hoop
    • , Michel Campillo
    •  & Richard Baraniuk
  • Article
    | Open Access

    Despite recent progress to advance cardiac cell-based therapy for patients, heart failure mortality rivals most cancers. Here, the authors describe an approach to control and pattern 3 distinct human cardiac cell populations to promote superior repair and regeneration after myocardial infarction.

    • Megan M. Monsanto
    • , Bingyan J. Wang
    • , Zach R. Ehrenberg
    • , Oscar Echeagaray
    • , Kevin S. White
    • , Roberto Alvarez Jr.
    • , Kristina Fisher
    • , Sharon Sengphanith
    • , Alvin Muliono
    • , Natalie A. Gude
    •  & Mark A. Sussman
  • Article
    | Open Access

    Mevalonate diphosphate decarboxylase (MDD) is a key enzyme in the mevalonate pathway and catalyses the decarboxylation of mevalonate-5-diphosphate to isopentenyl diphosphate. Here, the authors provide insights into the conformational changes that occur during substrate binding of MDD and the subsequent enzymatic reaction steps by determining the substrate and intermediate bound crystal structures of Enterococcus faecalis MDD.

    • Chun-Liang Chen
    • , Lake N. Paul
    • , James C. Mermoud
    • , Calvin Nicklaus Steussy
    •  & Cynthia V. Stauffacher
  • Article
    | Open Access

    The molecular determinants of differential responses of different cancer cells to methionine restriction are poorly understood. Here the authors show that hepatocyte nuclear factor 4α regulates sulfur amino acid metabolism and dictates the sensitivity of liver cancer to this dietary manipulation.

    • Qing Xu
    • , Yuanyuan Li
    • , Xia Gao
    • , Kai Kang
    • , Jason G. Williams
    • , Lingfeng Tong
    • , Juan Liu
    • , Ming Ji
    • , Leesa J. Deterding
    • , Xuemei Tong
    • , Jason W. Locasale
    • , Leping Li
    • , Igor Shats
    •  & Xiaoling Li
  • Article
    | Open Access

    The evolutionary relationships within Archaea remain unresolved. Here, the authors used genomic approaches to study the Undinarchaeota, a previously uncharacterized clade of DPANN, shed light on their position in an updated archaeal phylogeny and illuminate the history of archaeal genome evolution.

    • Nina Dombrowski
    • , Tom A. Williams
    • , Jiarui Sun
    • , Benjamin J. Woodcroft
    • , Jun-Hoe Lee
    • , Bui Quang Minh
    • , Christian Rinke
    •  & Anja Spang