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Electroreduction of NO3− to NH3 is drawing increasing interest. Here, the authors designed a CuCo catalyst imitating the bifunctional nature of Cu-type nitrite reductase to deliver an ampere-level current density for NH3 formation.
Recently, strategies based on the integration of nanotechnology with microbial carriers have been proposed for cancer therapy. Here the authors report the design of an ultrasound-controlled CRISPR/Cas9 gene editing system for IDO1 silencing compounded with the probiotic Lactobacillus rhamnosus GG, showing the induction of anti-tumor immune responses in preclinical cancer models.
The authors present single-pixel imaging accelerated via swept aggregate patterns (SPI-ASAP), which combines a digital micromirror device with laser scanning for fast and reconfigurable pattern projection, and a lightweight reconstruction algorithm. They demonstrate real-time video streaming at 100 fps, and up to 12,000 fps offline.
Ultracold ensembles are promising sources for precision measurements when their quantum state can precisely be prepared. Here the authors achieve a quantum state engineering of Bose-Einstein condensates in space using NASA’s Cold Atom Lab aboard the International Space Station making a step forward towards space quantum sensing.
Phase separation provides intracellular organisation via membraneless entities called biomolecular condensates. Here, the authors show that short, cationic peptide tags can drive biomolecular condensation of engineered proteins in E. coli through associative interactions with RNA.
Longitudinal proteomics holds great promise for biomarker discovery, but the data interpretation has remained a challenge. Here, the authors evaluate several tools to detect longitudinal differential expression in proteomics data and introduce RolDE, a robust reproducibility optimization approach.
Nanocomposites are promising dielectric candidates due to their nano-modification effect. Here authors report homogeneous nano-sieves of different pore sizes and incorporate them uniformly into P(VDF-HFP)-based films with extremely low dopings.
Neuronal activity increases local cerebral blood flow (CBF) to satisfy metabolic demand, yet the role of astrocytes in this phenomenon is controversial. Here, the authors show that astrocytes amplify CBF only when neuronal activity is sustained.
Tiny airborne particles play a critical role in two major environmental issues: climate change and air pollution. Our study highlights the important, yet often overlooked non-linear interaction of organic compounds on the formation of such particles.
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predict the development of kidney failure.
Neural circuit dynamics are thought to drive temporally precise actions. Here, the authors used a theoretical approach to show that synapses endowed with diverse short-term plasticity can act as tunable timers sufficient to generate rich neural dynamics.
The preparation of single-atom catalysts still suffers from metal aggregation and pore collapsing during pyrolysis. Here the authors report a versatile medium-induced infiltration deposition strategy for the fabrication of a series of single-atom and hetero-single-atom catalysts.
Probing the localized electrocatalytic activity of heterogeneous electrocatalysts is crucial. Here, the authors propose a method of imaging the surface charge density and electrocatalytic activity of single two-dimensional electrocatalyst nanosheets.
SARM1 is a key player in axon degeneration. Here, the authors generate a nanobody, which specifically recognizes the NMN-bound state of SARM1 and helps resolve the SARM1 structure in an intermediate state of activation.
The power of pangenomic graphs to improve genetic mapping is still unclear. Here, the authors demonstrate its value in identification of genetic variants associated with disease resistance traits in melon using PanPipes, a pangenome construction and low-coverage genotype-by-sequencing pipeline.
Grammar learning requires memory for temporally organised, rule-based patterns in speech. Here, the authors use event-related potentials to show that 6 to 8 month-old infants can form memory of dependencies between nonadjacent elements in sentences of an unknown language, regardless of whether they nap or stay awake after encoding.
Undesired chromosomal translocations, vector integrations, and large deletions remain a problem for therapeutic gene editing in vivo. Here, the authors compare the CRISPR-Cas9TX variant with CRISPR-Cas9 and show elimination of chromosomal translocations and reduction of AVV integration when targeting Vegfa for the treatment of age-related macular degeneration in a mouse model.
Ungulate herbivory is an important driver of ecological change in forests. Here, the authors combine vegetation resurveys showing herbivory effects are highly dependent on soil eutrophication, promoting non-natives under high N-conditions, yet benefiting threatened species under low N-conditions.
Here, the authors show that the glycosylceramide synthesis inhibitor and FDA approved drug Eliglustat inhibits autophagic degradation of TRAF3 which is a key step for osteoclast differentiation and thereby improves myeloma bone lesions.
How electron energy damp to lattice vibrations (phonons) in MXenes has not yet been unraveled. Here, the authors demonstrate an energy damping channel in which the Ti3C2Tx plasmonic electron energy transfers to coherent phonons by nonthermal electron mediation after Landau damping, without involving electron-electron scattering.