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Appropriate processing of value information is essential for survival. Here the authors show that in mice, serotonergic activations originating from the median raphe nucleus facilitated aversion in a pathway-dependent manner, while silencing this pathway was rewarding.
The mutation rate at any specific position in the human genome depends on sequence context. Here, the authors develop a method for predicting mutation rates of point mutations and indels based on sequence context; the results can be used to find genes where de novo mutations cause disease and genes under strong selective constraint.
Rhizosphere microbiota can influence plant pathogen interactions. Here the authors use field- and lab-based approaches to show that rhizosphere bacteria and fungi of healthy tomatoes can enhance tomato resistance against Fusarium wilt disease and formulate synthetic microbial communities that could help to control soil-borne disease.
Solving the many-body electronic structure of real solids is a grand challenge in condensed matter physics and materials science. Here authors present a machine learning ab initio architecture for real solids, which combines molecular neural network wavefunction ansatz and periodic features, providing accurate solutions for a range of solids.
Lamin A/C gene mutations cause dilated cardiomyopathy associated with cofilin-1 phosphorylation and actin destabilization. Here, the authors show that phosphorylated cofilin-1 blunts the MRTF-A/SRF axis, leading to decreased tubulin acetylation and altered cardiac structure and function.
Quantifying communication capabilities produced by sharing an entangled qubit pair is still a subject of debate. Here the authors show that there are communication tasks for which sharing an entangled pair gives higher power than sharing two classical bits, even when there is no entanglement in the measurements.
Biological cell membranes can efficiently switch Na+/K+ selectivity in response to external stimuli but achieving analogous functions in a single artificial membrane is challenging. Here, the authors report highly crystalline covalent organic framework membranes with well-defined nanochannels and coordinative sites that act as ion-selective switches to manipulate Na+ and K+ transport.
Supracrustal rocks of the Yilgarn orogen underwent deep burial, and later syn-shortening exhumation. Archean exhumation processes were likely less efficient that today, so that complete exhumation of high-pressure rocks was rare and accidental.
‘Pure organic room-temperature phosphorescence (RTP) materials with circularly polarized luminescence (CPL) gained increasing interest. Here, the authors propose a photoinduced circularly polarized RTP material by homogeneously dispersing phosphorescent chiral polyacetylenes into a processable polymer matrix.
SUMOylation is a mechanism of posttranslational modification involved in eukaryotic cell homeostasis. Here the authors report that mice unable to control SUMOylation in the adrenal cortex develop a selective defect in glucocorticoid production due to disrupted differentiation of cells involved in steroid hormone synthesis.
The authors demonstrate a multi-dimensional communication scheme that combines wavelength- and mode- multiplexing on photonic integrated circuits using foundry-compatible photonic inverse design and spectrally flattened microcombs
A valve-like structure called this Sertoli valve (SV) supports spermatogenesis by modulating the directional fluid flow in mouse testis. The SV formation is supported by its neighboring SOX17 + rete testis (RT). This study highlights the essential roles of RT and SV in spermatogenesis.
Here, the authors use an advanced data-mining method to show how “extreme modes” of large-scale climate variability, such as El Niño, can lead to devastating marine heatwaves.
While heart disease, dementia and liver disease often co-occur, multi-organ imaging is needed for deeper elucidation of these cross-organ links. Here, the authors use image-derived phenotypes to describe underlying associations between heart, brain and liver health in a large population cohort.
By following morphological changes in supramolecular assemblies of silkworm silk, the authors find that while the initial steps of secretion and storage inside the silk gland follow the micelle theory of silk assembly, a phase rearrangement occurs inside microscale spherical structures that gives rise to the formation of nanoscale spherical assemblies.
To date, no Ca2 + -selective channelrhodopsins have been characterized. In this study, Fernandez Lahore et al. report two calcium-permeable channelrhodopsins (CapChR1 and 2) for the photocontrol of calcium signalling in excitable tissue.
This study presents a global well-to-wake assessment of jet fuel greenhouse gas emissions with a range of 81.1-94.8 gCO2e MJ−1. Understanding this variability can improve decision-making amid the transition to decarbonizing aviation.
The authors present an approach to phase imaging by using the non-local optical response of a guided-moderesonator metasurface. They demonstrate that this metasurface can be added to a conventional microscope to enable quantitative phase contrast imaging.
A central concept for characterising phase-separating systems is the phase diagram but generation of such diagrams for biomolecular systems is typically slow and low-throughput. Here the authors describe PhaseScan, a combinatorial droplet microfluidic platform for high-resolution acquisition of multidimensional biomolecular phase diagrams.
Enzymes have potential for recycling plastics such as PET, a polyester used in textiles and single-use packaging. Here, the authors identify and characterize additional PET-active biocatalysts and expand the number and diversity of thermotolerant scaffolds for enzymatic PET deconstruction.