Articles in 2010

The magnetic flux lines in a superconductor present intricate patterns, whose origins are seldom understood. Here the authors link them to geometrical effects by means of the 'hairy ball' theorem, which states that for a vector field on a sphere there will always be at least one singularity.

The complex electronic motion in the quantum Hall regime in semiconductors has so far eluded analysis of its microscopic structure. Here, the authors use scanning gate microscopy to measure the spatial structure of transport inside a metal in this regime, opening the way for localized manipulation of the electronic states.

Calmodulin is a key mediator of calcium-dependent signalling and is subject to post-translational modifications. Here, evolutionarily conserved methyltransferases are identified which trimethylate Lys-115 of calmodulin, implying a broad role in calcium-dependent signalling.

The Hand1 transcription factor plays a central role in cardiovascular development. Here the authors demonstrate that Hand1 regulates thymosin β4 and that the delivery of synthetic thymosin β4 can rescue some of the vascular defects in Hand1 null mouse embryos.

Poor maternal nutrition is known to affect fetal kidney development. This study shows that the sodium potassium ATPase ligand, ouabain, protects kidneys from cell death induced by serum starvationin vitro and from abnormal kidney development due to a low-protein diet in vivo.

It was previously thought that the nerves in the pectoral fin of fish came solely from the spinal cord. Here, motoneurons in ray-finned fish are shown to also originate from the hindbrain, demonstrating that innervation was from both the hindbrain and the spinal cord in ancesteral vertebrates.

Pseudogenes are prevalent in the human genome; however, their biological function is relatively unknown. In this study, the high mobility group A1 (HMGA1) pseudogene is shown to destabilizeHMGA1 mRNA. These findings have implications for diabetes, as two patients are reported to express high levels of the HMGA1pseudogene.

Multifunctional imaging probes are important in bionanotechnology. In this paper, the authors show that nanoparticles with magnetic cores, thin gold shells and an organic spacer layer support a novel magnetomotive photoacoustic imaging mode, and enhance contrast with respect to conventional imaging techniques.

A recent X-ray structure revealed the closed state of a P2X receptor ion channel. Here, Li and colleagues probe the structural rearrangements that take place during channel opening by measuring the effects of covalent modification of engineered cysteines.

Synthetic nanomotors convert chemical energy into motion. Here, they have been implemented in a motion-based assay that allows specific DNA and ribosomal RNA detection. The technique is fast, simple and sensitive, and the concentration-dependant distance signals of the magnetically aligned nanomotors are detected by optical microscopy.

Fullerene peapods are carbon nanotubes encapsulating buckyball molecules. Here the authors show by low-temperature electron transport experiments, that the electronic states of nanotubes couple to the vibrational states of fullerenes, making the peapods a new class of nanoelectromechanical devices.

There has been great interest in attempting to identify gene expression signatures that predict cancer survival. In this study a new algorithm is developed to analyse gene expression datasets that accurately classify both ER+ and ER− breast cancers into low- and high-risk groups.

Phosphoinositides activate intracellular ion channels to release Ca²⁺ from membrane-bound stores. This study demonstrates that Ca²⁺-permeable mucolipin TRP channels, TRPMLs, are activated by the phospholipid PI(3,5)P₂in murine endolysosomes and yeast vacuoles.

The embryonic development of forelimbs and hindlimbs is regulated by transcription factors, including Pitx1, Tbx4 and Tbx5. In this study, the contributions of Tbx4 and Tbx5 to limb identity are further delineated, resulting in the demonstration of a role for Tbx4 in hindlimb skeletal and muscle patterning.

Graphene sheets used to build electronic devices have defects that limit performance. As a possible bottom-up route towards better devices, Diez-Perez and co-workers build large polyaromatic molecules with precisely defined structures which show good performance as field-effect transistors.

Dinosaur nesting sites have been found in many different places, but the factors that influenced the choice of location are unclear. Here, a sauropod nesting site is described in a geothermal setting in the Sanagasta Valley, suggesting that the dinosaurs used the warm environment to favour the incubation process.

For conservation purposes, accurate methods are required to track cotton-top tamarins in their natural habitat. As existing census methods are not appropriate for surveying these monkeys, a lure-transect method combined with playback vocalization was used here to allow accurate counting of the animals.

Recent work has revealed that the TTAGGG DNA repeats of telomeres are transcribed to form 'TERRA'. In this study, a set of RNA-binding proteins are shown to bind TERRA transcripts, altering the location of these transcripts at telomeres and regulating telomere abundance and length.

Understanding the details of domain wall motion in nanowires is important for magnetic racetrack memories. Jiang and co-workers show that this motion can become more random by varying the magnetic field, pinning the domains at several local imperfections of the nanowire.

Vaccination against one viral strain can result in cross-reactive antibodies against another viral strain. In this study, the vaccination of mice against the 2009 H1N1 virus is shown to protect mice from the 1918 Spanish influenza virus, which resulted in millions of deaths worldwide.