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Nature generates the stereoisomeric yohimbine alkaloids using bioavailable monoterpene secolaganin as the building block. Here, the authors reset the stage by the development of a bioinspired coupling, in which the pentacyclic skeleton is constructed through enantioselective kinetic resolution of an achiral, easily accessible synthetic surrogate.
Primary alkyl amines are highly reactive in N-nucleophilic reactions with electrophiles but their α-C–H bonds are unreactive towards electrophiles due to their extremely low acidity. Combining 8-diazafluoren-9-one with an iridium catalyst, the authors demonstrate direct asymmetric α-C-H alkylation of unprotected primary alkyl amines with allylic carbonates.
Microplastics research is often based on commercial model particles. Here, the authors show that nominally identical particles may differ significantly in their properties and thus in their interactions with cells.
CRISPR-Cas9 genome editing systems have great potential in cancer therapy. Here the authors report a gene-editing delivery system using functionalized nanovesicles derived from E. coli protoplasts to encapsulate Cas9-sgRNA ribonucleoprotein for the selective targeting of Pik3cg in tumor associated macrophages.
Multifunctional composite hydrogels are promising candidates to develop smart and recyclable electronic components. Here, the authors report a reversible on-demand liquefication and solidification conductive gel formed by the self-assembly of photoresponsive host-guest complexes and MXene nanosheets which can be integrated into traditional solid-state circuits.
The evolution of Pd-based material during CO2 electroreduction requires further investigation. Here the authors use in-situ liquid-phase transmission electron microscopy and select area diffraction characterization techniques to visualize the morphological and phase structure evolution of the Pd/PdHx catalysts under CO2 electroreduction conditions.
Upon cold exposure, two types of thermogenic fat cells, brown and beige adipocytes, are sequentially activated. Here, the authors show that E3 ubiquitin ligase RNF20 coordinates the sequential thermogenic activation through fat depot specific substrates.
Here, the authors show that multiyear prediction of marine habitat shifts can be skillfully accomplished by combining trait based aerobic habitat constraints with a suite of initialized retrospective Earth System Model temperature forecasts.
Age-associated myometrial dysfunction can cause complications during pregnancy and labor. Here, the authors report that aging myometrium is characterized by diminished contractile capillary cells, altered gene expression, and disrupted cellular communication leading to impaired angiogenesis, increased fibrosis and inflammation.
The authors showcase a five-channel silicon microring modulator array with a total data rate in the terabit range. Each microring is equipped with two separate Z-shape junctions to overcome the bandwidth and modulation efficiency trade-off, providing a pathway for future 200 Gb/s/lane silicon optical interconnects.
Here, the authors identify six risk SNPs for systemic sclerosis by performing GWAS on Japanese patients and meta-analyzing Japanese and European GWAS datasets. Downstream analyses indicate that B cells contribute to pathogenesis.
Small GTPases such as Rabs control the positioning of lysosomes. Here, the authors unveil a molecular cascade orchestrated by Arl8/DENND6A/Rab34 that regulates lysosome location, impacting autophagy.
High-throughput electron microscopy demands minimal human intervention and high image quality. Here, authors introduce DeepFocus, a data-driven method for aberration correction in electron microscopy, robust for low SNR images, fast and easily adaptable to microscopes and samples. Peer Review Information:Nature Communications thanks Yang Zhang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. A peer review file is available.
Modeling shows that N2O emissions from global lakes and reservoirs have doubled since the pre-industrial era, this was mainly caused by widespread agricultural nitrogen application.
Here the authors unveil an approach rooted in non-Hermitian physics to precisely control light amplification in an integrated photonic platform, paving the way for innovative on-chip functionalities, like coherent control of light amplification and routing.
The role of the cerebellum in language processing remains unclear. Here, the authors use a biologically-constrained artificial cerebellar neural network to reveal a dual role of single circuit computation in syntax and word prediction.
Via the first-principles calculations and experimental verifications, a guiding principle is established to design heteroatom-doped-graphene-supported Ca single-atom carbon nanomaterials for efficient non-dissociative solid-state hydrogen storage.
Traditional mineralization of organic pollutants requires an excessive input of chemicals and causes undesirable carbon emissions. Here, authors report a nanoconfinement strategy to alter the carbon transfer pathway of phenol removal from ring opening route to oligomerization route.
Although most patients achieve complete response after standard-of-care treatment, residual disease in patients with nasopharyngeal carcinoma is associated with poor prognosis. Here the authors report the results of a phase 2 trial of toripalimab (anti-PD1) plus capecitabine for patients with residual nasopharyngeal carcinoma.
The ecology of Ebola virus (EBOV) is still largely unclear. Here, the authors show that Angolan freetailed bats are selectively permissive to EBOV infection, but not to other filoviruses, and demonstrate EBOV placental tissue tropism indicating potential horizontal and vertical transmission between conspecifics.