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  • Ionic covalent organic frameworks (iCOFs) are new examples of porous materials and show great potential for various applications. Here, the authors demonstrate functionalization of an iCOFs with suitable emission sites and application as chemosensor for amine detection with high sensitivity which can be used to monitor meat spoilage.

    • Gobinda Das
    • Bikash Garai
    • Ali Trabolsi
    Article Open Access
  • The highest tensile strength biomaterial known exists in limpet teeth and replicating this material is of interest. Here, the authors report on the ex vivo growth of teeth and use of isolated limpet tissue and cells providing foundations for the development of this high-tensile biomaterial.

    • Robin M. H. Rumney
    • Samuel C. Robson
    • Dariusz C. Górecki
    Article Open Access
  • Here, the authors report the realization of light-emitting field-effect transistors based on van der Waals heterostructures with conduction and valence band edges at the Γ-point of the Brillouin zone, showing electrically tunable and material-dependent electroluminescence spectra at room temperature.

    • Hugo Henck
    • Diego Mauro
    • Alberto F. Morpurgo
    Article Open Access
  • Developing materials for uranium harvesting from seawater with high adsorption capacity remains challenging. Here, the authors develop a new protocol, by combining multi-scale computational simulations with the PET-RAFT polymerization, for rational design and precise synthesis of block copolymers with optimal architectures and atomic economy, achieving a capacity of 11.4 mg/g within 28 days.

    • Zeyu Liu
    • Youshi Lan
    • Gang Ye
    Article Open Access
  • Whole-cell screening for Mycobacterium tuberculosis inhibitors is complicated by the pathogen’s slow growth and biocontainment requirements. Here the authors develop engineered E. coli as a synthetic biology tool to express and screen metabolic targets from Mycobacterium tuberculosis.

    • Nadine Bongaerts
    • Zainab Edoo
    • Edwin H. Wintermute
    Article Open Access
  • Periprosthetic osteolysis is a cause of arthroplasty failure without available therapies. Here the authors show that Annexin A1 (AnxA1) is involved in in periprosthetic osteolysis and exerts potential therapeutic effects through suppressing NFκB signaling and promoting the PPAR-γ pathway resulting in inhibition of inflammation and osteoclasts differentiation induced by wear debris.

    • Hend Alhasan
    • Mohamad Alaa Terkawi
    • Norimasa Iwasaki
    Article Open Access
  • The range of available copy numbers for cloning vectors is largely restricted to the handful of ORIs that have been isolated from plasmids found in nature. Here the authors introduce a plasmid system that allow for the continuous, finely-tuned control of plasmid copy number between 1 and 800 copies per cell.

    • Miles V. Rouches
    • Yasu Xu
    • Guillaume Lambert
    Article Open Access
  • Despite the advantages of biohybrid systems for soft robotics, most systems have short lifetime, require complex fabrication, and only remain functional with careful maintenance. Here, the authors report biohybrid mechanoluminescence in soft elastomer-encapsulated bioluminescent dinoflagellates.

    • Chenghai Li
    • Qiguang He
    • Shengqiang Cai
    Article Open Access
  • Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality. Inhibition of mitochondrial fusion promotes minority MOMP, caspase-3/7 activation, and DNA damage.

    • Emmanouil Zacharioudakis
    • Bogos Agianian
    • Evripidis Gavathiotis
    Article Open Access
  • Mid-infrared photonic integrated circuits (PICs) are important for sensing and optical communications, but their operational wavelengths are usually limited below 4 μm. Here, the authors report the realization of photothermoelectric graphene photodetectors incorporated in a chalcogenide glass-on-CaF2 PIC operating at 5.2 μm, showing promising results for gas sensing applications.

    • Jordan Goldstein
    • Hongtao Lin
    • Dirk Englund
    Article Open Access
  • Measurement-device-independent QKD schemes suffer from a trade-off between ease of implementation (avoiding the need for global phase locking) and high rates (quadratic improvement in rate). Here, the authors propose a protocol which offers both simple implementation and strong performances.

    • Pei Zeng
    • Hongyi Zhou
    • Xiongfeng Ma
    Article Open Access
  • Why do males typically compete more intensely for mating opportunities than do females and how does this relate to sex differences in gamete size? A new study provides a formal evolutionary link between gamete size dimorphism and ‘Bateman gradients’, which describe how much individuals of each sex benefit from additional matings.

    • Jonathan M. Henshaw
    • Adam G. Jones
    • Lukas Schärer
    Comment Open Access
  • The study of the mechanical properties of twisted van der Waals structures can provide important information about their interlayer coupling and electronic behaviour. Here, the authors report a nanoindentation-based technique to determine the interlayer shear stress in bilayer MoS2, showing its independence as a function of the twist angle.

    • Yufei Sun
    • Yujia Wang
    • Kai Liu
    Article Open Access
  • EGFR regulates cellular processes across the animal kingdom. Here, the authors show that transmembrane conformational coupling is the first step in EGFR signaling, providing evidence for the existence of transmembrane intramolecular conformational changes in a single pass membrane protein.

    • Shwetha Srinivasan
    • Raju Regmi
    • Gabriela S. Schlau-Cohen
    Article Open Access
  • Despite the importance of unsymmetrical disulfides in various fields such as food chemistry, pharmaceutical industry, and polymer science, the nondirected intermolecular disulfuration of C-H bonds remains challenging. Here, the authors report the conversion of aliphatic C(sp3)-H bonds and aldehydic C(sp2)-H bonds into the corresponding C-SS bonds with tetrasulfides (RSSSSR) as radical disulfuration reagents.

    • Jingjing Zhang
    • Armido Studer
    Article Open Access