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Volume 17 Issue 3, March 2021

Volume 17 Issue 3

Coupled conformations

Single-molecule FRET sensors made by incorporating unnatural amino acids shed light on the mechanism of allosteric activation in mGluR2 metabotropic glutamate receptors, revealing how conformational changes of the ligand-binding domain with loose coupling to the cysteine-rich domain propagate during receptor activation.

See Liauw et al.

Image: Michelle Harris Cover Design: Alex Wing.

Research Highlights

News & Views

  • News & Views |

    The cumbersome encoding of digital data to cellular DNA hinders the use of cells as living hard drives. A new approach transfers digital information directly into cellular DNA by converting electrical signals into stable and interpretable changes in the genomes of bacterial populations.

    • Santi Bhattarai-Kline
    • Sierra K. Lear
    • Seth L. Shipman
  • News & Views |

    A chemical screen identifies BET bromodomain inhibitors as inducers of an activated skin keratinocyte state that promotes the wound-healing capabilities of these cells. The study implicates epigenetic modifiers as potential targets for non-healing, chronic wounds.

    • Irene Ylivinkka
    • Sara A. Wickström
  • News & Views |

    Directed evolution on the yeast cell surface enables the discovery of sortase variants with altered specificity capable of modifying Aβ peptides under physiologically relevant conditions.

    • James A. Van Deventer



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