Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 17 Issue 3, March 2021

Volume 17 Issue 3

Coupled conformations

Single-molecule FRET sensors made by incorporating unnatural amino acids shed light on the mechanism of allosteric activation in mGluR2 metabotropic glutamate receptors, revealing how conformational changes of the ligand-binding domain with loose coupling to the cysteine-rich domain propagate during receptor activation.

See Liauw et al.

Image: Michelle Harris Cover Design: Alex Wing.

Research Highlights

News & Views

  • News & Views |

    The cumbersome encoding of digital data to cellular DNA hinders the use of cells as living hard drives. A new approach transfers digital information directly into cellular DNA by converting electrical signals into stable and interpretable changes in the genomes of bacterial populations.

    • Santi Bhattarai-Kline
    • Sierra K. Lear
    • Seth L. Shipman
  • News & Views |

    A chemical screen identifies BET bromodomain inhibitors as inducers of an activated skin keratinocyte state that promotes the wound-healing capabilities of these cells. The study implicates epigenetic modifiers as potential targets for non-healing, chronic wounds.

    • Irene Ylivinkka
    • Sara A. Wickström
  • News & Views |

    Directed evolution on the yeast cell surface enables the discovery of sortase variants with altered specificity capable of modifying Aβ peptides under physiologically relevant conditions.

    • James A. Van Deventer

Perspectives

Articles

Amendments & Corrections

Search

Quick links