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Volume 17 Issue 1, January 2021

Volume 17 Issue 1

Protected by the peroxisome

In yeast, targeting potentially toxic proteins to the peroxisome (here demonstrated with yellow fluorescent protein) protects the cell from harmful effects. Using this peroxisome-targeting approach with the toxic enzyme norcoclaurine synthase enables increased production of (S)-reticuline and other alkaloids.

See Grewal et al.

IMAGE: Parbir Grewal and Jordan Baker. COVER DESIGN: Alex Wing.

Feature

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    We asked a collection of chemical biologists, “What is the most exciting frontier area in chemical biology and what key technology is needed to advance knowledge and applications in this area?” and reveal some of the perspectives we received.

News & Views

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    Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

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Review Articles

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    • Haridha Shivram
    • Brady F. Cress
    • Jennifer A. Doudna

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