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Volume 15 Issue 12, December 2019

Volume 15 Issue 12

Logical ribosome regulation

Engineered RNA molecules have been designed from scratch to precisely turn off protein expression and implement multi-input universal logic gates in Escherichia coli. The cover depicts an RNA circuit for computing NAND logic in the process of being switched off.

See Kim et al

IMAGE: Alexander Green. COVER DESIGN: Erin Dewalt

Research Highlights

News & Views

  • News & Views |

    The last step of archaeosine biosynthesis was found to involve two enzymes, the previously known ArcS with lysine transfer activity and a novel identified radical SAM enzyme named RaSEA.

    • Mohamed Atta
  • News & Views |

    Actin cytoskeletal structures are essential for many cellular processes, and cofilin is a key protein for the assembly of these highly dynamic structures. A new cofilin construct enables precise optogenetic control of actin assembly in live cells.

    • Qian Chen
  • News & Views |

    The regulation of brain iron homeostasis, previously thought to be cell autonomous and modulated by local factors in the interstitial fluid, is reported by Wang et al. to be strongly influenced by axonal transport of iron in an activity-dependent and unidirectional manner between functionally associated regions. The supply of iron from the ventral hippocampus to the middle prefrontal cortex subserved an anxiolytic phenotype and mediated the neuropharmacological actions of diazepam and lithium chloride in rodent models.

    • Peng Lei
    • Scott Ayton
    • Ashley I. Bush

Perspectives

  • Perspective |

    This Perspective focuses on the chemical basis of ferroptotic cell death, discussing the prominent role of spontaneous chemical reactions, how they depend on enzyme-catalyzed processes and how to exploit this interplay for therapeutic benefit.

    • Marcus Conrad
    • Derek A. Pratt

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