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The large number of available chemical strategies to modify biomolecules can be overwhelming and time-consuming if adopted without careful consideration. Applying chemical logic to select context-dependent protocols can streamline this process substantially, leading to a wealth of functionalized materials for use in biology and materials science.
Antibiotics are critical defenses in the fight against bacterial infections, but they can also be used as probes to explore basic microbiology, including cell division, stress responses and cell wall biosynthesis, and will be valuable tools in deciphering bacterial networks and complexity.
The nonlinear variant of Raman spectroscopy, coherent anti-Stokes Raman scattering (CARS) microscopy, combines powerful Raman signal enhancement with several other advantages such as label-free detection and has been used to image various cellular processes including host-pathogen interactions and lipid metabolism.
