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    RNA has occupied a pivotal position in the 'central dogma' of molecular biology, which states that information flows from DNA through RNA to proteins. In this issue, we feature a collection of articles that discuss the diverse functional roles of RNA in biological systems and highlight recent discoveries in RNA chemical biology, including advances in transcription, RNA structural biology, RNA interference and RNA engineering.

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    The development of new therapeutic agents has required the close collaboration of chemists and biologists in identifying drug targets or lead compounds and developing them toward the clinic. This month we include a series of articles that focus on how chemical biologists in academic and industrial settings enhance our understanding of biological systems and advance the next generation of therapeutic agents.

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    The June 2006 issue represents one year of Nature Chemical Biology. To mark our anniversary, we have compiled some highlights from our first 12 issues. These free items reflect the editorial scope and the diversity of content featured in Nature Chemical Biology. We hope that you will enjoy them and look forward, with us, to our second year of publication of research at the interface of chemistry and biology.