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Protein condensates are subcellular structures that enrich and confine molecules in cells. This Review details how condensates can be engineered with responsiveness and on-demand functions, thus pushing cellular and metabolic engineering to a new level.
This Review introduces molecular features of the phase-separating biomolecules and how they affect phase-separation behavior in a complex intracellular environment, highlighting a complex interplay between structure, sequence and environment in the phase-separation process.
Several venomous predators and pathogens use insulins to capture prey and to manipulate host physiology. This Review provides an overview of the discovery and potential biomedical application of these and other weaponized hormones found in nature.
This Review discusses how combining computational modeling with multiparametric profiling of small-molecule effects can accelerate and expand the search for new and unconventional antibacterial strategies.
Succinate may have evolved as a signaling modality because its concentration reflects the redox state of the mitochondrial coenzyme Q pool, thus communicating to the rest of the cell and beyond about electron supply, oxygen tension and ATP demand.
Lipid metabolism is a major regulator of T cell biology, and this Review Article highlights mechanisms by which diverse lipids modulate T cell signaling and opportunities for therapeutic intervention on targets within these immunological pathways.
