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ComX is a post-translationally modified peptide involved in quorum sensing in Bacillus subtilis. The structure of ComX has now been shown to contain a geranylated tryptophan with an unusual tricyclic architecture.
Nitric oxide signaling requires that the heme of soluble guanylate cyclase bind NO preferentially to O2. Engineering of the enzyme's active site reveals a molecular basis for NO binding selectivity.
The fate of cells depends on a delicate balance of pro- and anti-apoptotic proteins. Small-molecule inhibitors of anti-apoptotic protein-protein interactions promote apoptosis in cancer cells.