Nitric oxide signaling requires that the heme of soluble guanylate cyclase bind NO preferentially to O2. Engineering of the enzyme's active site reveals a molecular basis for NO binding selectivity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Boon, E.M., Huang, S.H. & Marletta, M.A. Nat. Chem. Biol. 53–59 (2005).
Spiro, T.G. & Kozlowski, P.M. Acc. Chem. Res. 34, 137–144 (2001).
Springer, B.A., Sligar, S.G., Olson, J.S. & Phillips, G.N. Chem. Rev. 94, 699–714 (1994).
De Angelis, F., Jarzecki, A.A., Car, R. & Spiro, T.G. J. Phys. Chem. B 109, 3065–3070 (2005).
Gilles-Gonzalez, M.A. & Gonzalez, G. J. Inorg. Biochem. 99, 1–22 (2005).
Denninger, J.W. & Marletta, M.A. Biochim. Biophys. Acta 1411, 334–350 (1999).
Iyer, L.M., Anantharaman, V. & Aravind, L. BMC Genomics 4, 5 (2003).
Karow, D.S. et al. Biochemistry 43, 10203–10211 (2004).
Pellicena, P., Karow, D.S., Boon, E.M., Marletta, M.A. & Kuriyan, J. Proc. Natl. Acad. Sci. USA 101, 12854–12859 (2004).
Nioche, P. et al. Science 306, 1550–1553 (2004).
Kiger, L. et al. Biophys. J. 75, 990–998 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Spiro, T. Pulling NO out of thin air. Nat Chem Biol 1, 6–7 (2005). https://doi.org/10.1038/nchembio0605-6
Issue Date:
DOI: https://doi.org/10.1038/nchembio0605-6
