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Kinesins are the molecular motors responsible for movement of vesicles inside cells. Evidence is now presented for how kinesin moves forward, as well as side to side.
Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function.
The process of cellular engineering is rapidly accelerating owing to advances in technologies to manipulate DNA and other biomolecules, giving rise to the field of synthetic biology. A meeting was held in August 2005 to present progress in the field and to discuss topics in ethics, safety and security.
Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics.
Coelichelin is a new tetrapeptide siderophore from Streptomyces coelicolor originally discovered by gene sequence analysis. Surprisingly, this tetrapeptide is assembled by a trimodular nonribosomal peptide synthetase.
Unlike many site-specific recombinases that require accessory proteins, the Cre recombinase itself organizes a synaptic complex to initiate the recombination reaction. A new study suggests how Cre recombinase accomplishes this catalytic feat.
The high polyunsaturated fatty acid content of mammalian sperm cell membranes makes them vulnerable to damaging oxidation. A carbohydrate-antioxidant polymer has been developed that greatly increases antioxidant levels in sperm, counteracting any detrimental effects and improving sperm function.
Nitrite, a ubiquitous stable oxidation byproduct of nitric oxide (NO) metabolism, is now entering the pantheon of signaling biochemical molecules. Nitrite may have the unique properties of a blood and tissue NO reservoir activated by physiological and pathological hypoxia.
Chemical biology, broadly defined as the application of chemistry to the study of molecular events in biological systems, presents an opportunity for the reorganization and revitalization of the chemistry curriculum.
From the complex behavior of multicomponent signaling networks to the structures of large protein complexes and aggregates, questions once viewed as daunting are now being tackled fearlessly by protein scientists. The 19th Annual Symposium of the Protein Society in Boston highlighted the maturation of systems biology as applied to proteins.
