A fluorescence image of two cortical neurons labelled for filamentous actin (red) and microtubules (green). The round cell on the left was transfected with a construct that sequesters Ena/VASP proteins to mitochondria (blue); this inhibits filopodia formation and neurite outgrowth.

During anaphase of one-cell stage Caenorhabditis elegans embryos, spindle positioning is mediated by microtubules (white and green), as well as dynein (red).

Post-mitotic nuclear envelope assembly involves ER reorganization by chromatin.

This issue of Nature Cell Biology includes a series of six specially commissioned articles that collectively highlight how misfunctioning developmental pathways can cause disease. The articles are freely accessible until February 2008 at www.nature.com/ncb/webfocus/developmentdisease

Compartmentalization of homologous recombination. Three-dimensional view of a DNA repair centre (yellow), the nucleus (red) and the nuclear periphery (blue) by fluorescence microscopy. DNA breaks in ribosomal genes exit from the nucleolus for repair.

Confocal fluorescence micrograph of chromosomes and microtubules in a living mammalian cell. The sister chromatids are shown just after separation in anaphase, when maximal compaction by axial shortening begins.

Tiny peptides, encoded by a polycistronic mRNA are essential for F-actin organization during epidermal denticle formation in Drosophila

The kinetochore outer plate in PtK1 cells is a fibrous network (yellow) that forms multiple attachments to both the plus-end tips and the walls of spindle microtubules (red).

IKK1[letter p461]

[letter p310]

Chemotaxis in Dictyostelium is driven by the selective retention of randomly generated pseudopods.

Sharp Dpp boundaries sculpt fly legs by triggering cell death in the joints.