Volume 21 Issue 3, March 2019

Volume 21 Issue 3

Mechanobiology

The Golgi links contractility to lipid synthesis

See Romani et al. and News & Views by Thery

Image: Image courtesy of Patrizia Romani and Sirio Dupont. Cover Design: Lauren Heslop.

News & Views

  • News & Views |

    Healthy and malignant haematopoietic stem cells (HSCs) must overcome a variety of cell intrinsic and extrinsic stresses to maintain their functionality. Now, IRE1α –XBP1 signalling is shown to protect HSCs and to promote survival of, and confer competitive advantages to, NRAS-mutated pre-leukaemic cells.

    • Marina Scheller-Wendorff
    •  & Carsten Müller-Tidow
  • News & Views |

    Epithelial–mesenchymal transition (EMT) is crucial for development, and for dissemination and invasion of cancer cells. A study now identifies the apical–basolateral polarity status of epithelia as a checkpoint for EMT induction and tumour metastasis through aPKC–Par3-regulated degradation of the EMT transcription factor SNAI1.

    • Oana-Diana Persa
    •  & Carien M. Niessen
  • News & Views |

    Cell metabolism ensures that cell dynamics and continued renewal are supported by a constant flow of matter that consumes energy. A new study shows that cell metabolism is sensitive to mechanical cues, revealing that the level of cell contraction modulates the production and storage of lipids, which could serve as fuel for energy production.

    • Manuel Théry
    •  & Mario Pende
  • News & Views |

    Ancestral experience of mitochondrial stress is now found to render progeny of the roundworm Caenorhabditis elegans more resistant to the same insult for up to four generations. A DNA modification, N6-methyldeoxyadenine, is implicated in the inheritance of this stress adaptation.

    • Sarah-Lena Offenburger
    • , Marcos Francisco Perez
    •  & Ben Lehner

Letters

  • Letter |

    Kraft et al. show that chromosomal inversions that relocate a limb enhancer can establish asymmetric stripes of the enhancer with downstream genes, resulting in ectopic gene expression and limb phenotypes.

    • Katerina Kraft
    • , Andreas Magg
    • , Verena Heinrich
    • , Christina Riemenschneider
    • , Robert Schöpflin
    • , Julia Markowski
    • , Daniel M. Ibrahim
    • , Rocío Acuna-Hidalgo
    • , Alexandra Despang
    • , Guillaume Andrey
    • , Lars Wittler
    • , Bernd Timmermann
    • , Martin Vingron
    •  & Stefan Mundlos
  • Letter |

    Nakamura et al. show that DNA repair pathway choice and initiation of homologous recombination is guided by the recruitment of BRCA1 to post-replicative chromatin by BARD1 recognition of histone H4 tails unmethylated on lysine 20.

    • Kyosuke Nakamura
    • , Giulia Saredi
    • , Jordan R. Becker
    • , Benjamin M. Foster
    • , Nhuong V. Nguyen
    • , Tracey E. Beyer
    • , Laura C. Cesa
    • , Peter A. Faull
    • , Saulius Lukauskas
    • , Thomas Frimurer
    • , J. Ross Chapman
    • , Till Bartke
    •  & Anja Groth

Articles

  • Article |

    Liu et al. show that the adaptive branch of unfolded protein response signalling, IRE1α–XBP1, protects haematopoietic stem cells and N-Ras pre-leukaemic stem cells from endoplasmic reticulum stress-induced apoptosis and supports their self-renewal.

    • Lu Liu
    • , Meiling Zhao
    • , Xi Jin
    • , Gina Ney
    • , Kevin B Yang
    • , Fanglue Peng
    • , Jin Cao
    • , Takao Iwawaki
    • , Juan Del Valle
    • , Xi Chen
    •  & Qing Li
  • Article |

    Romani et al. identify a response to reduced actomyosin contractility involving inhibition of Lipin-1, accumulation of SREBP transcription factors at the Golgi apparatus and activation of SREBP transcription driving increased lipid synthesis.

    • Patrizia Romani
    • , Irene Brian
    • , Giulia Santinon
    • , Arianna Pocaterra
    • , Matteo Audano
    • , Silvia Pedretti
    • , Samuel Mathieu
    • , Mattia Forcato
    • , Silvio Bicciato
    • , Jean-Baptiste Manneville
    • , Nico Mitro
    •  & Sirio Dupont
  • Article |

    Moro et al. discover an Argonaute 2 (Ago2)-dependent miRNA network that, in response to substrate stiffness, regulates genes involved in tissue mechanics, and show that Ago2 restrains stiffness and contributes to regeneration in the zebrafish fin fold.

    • Albertomaria Moro
    • , Tristan P. Driscoll
    • , Liana C. Boraas
    • , William Armero
    • , Dionna M. Kasper
    • , Nicolas Baeyens
    • , Charlene Jouy
    • , Venkatesh Mallikarjun
    • , Joe Swift
    • , Sang Joon Ahn
    • , Donghoon Lee
    • , Jing Zhang
    • , Mengting Gu
    • , Mark Gerstein
    • , Martin Schwartz
    •  & Stefania Nicoli
  • Article |

    Şentürk et al. show that ubiquilins bind v-ATPase to control lysosome acidity, mTOR signalling and autophagic flux in neurons, and that feeding flies with acidic nanoparticles ameliorates defective autophagy in ubiquilin mutants.

    • Mümine Şentürk
    • , Guang Lin
    • , Zhongyuan Zuo
    • , Dongxue Mao
    • , Emma Watson
    • , Antonios G. Mikos
    •  & Hugo J. Bellen
  • Article |

    Nacarelli et al. show that the nicotinamide-phosphoribosyltransferase-regulated NAD+ biogenesis pathway promotes the proinflammatory senescence-associated secretory phenotype by enhancing glycolysis and mitochondrial respiration during senescence.

    • Timothy Nacarelli
    • , Lena Lau
    • , Takeshi Fukumoto
    • , Joseph Zundell
    • , Nail Fatkhutdinov
    • , Shuai Wu
    • , Katherine M. Aird
    • , Osamu Iwasaki
    • , Andrew V. Kossenkov
    • , David Schultz
    • , Ken-ichi Noma
    • , Joseph A. Baur
    • , Zachary Schug
    • , Hsin-Yao Tang
    • , David W. Speicher
    • , Gregory David
    •  & Rugang Zhang

Amendments & Corrections