Volume 12 Issue 8, August 2010

Volume 12 Issue 8

Germline STAT activation regulates stem cell adhesion to the niche rather than their self-renewal.p806

Editorial

  • Editorial |

    The summer conference season is now in full swing. As scientists dash from session to session and venue to venue, now is a good time to take stock of what conference attendance seeks to achieve.

Turning Points

News and Views

  • News & Views |

    The bacterial cytoplasm is rich in filament-forming proteins, from homologues of eukaryotic cytoskeletal elements to other scaffolding and segregation proteins. We now learn that even the metabolic enzyme CTP synthase forms cytoplasmic filaments that affect bacterial cell shape.

    • Matthew T. Cabeen
    •  & Christine Jacobs-Wagner
  • News & Views |

    Three recent studies reveal unexpected functions of Rap1, a member of the shelterin complex that protects chromosome ends from the activity of DNA repair pathways. Rap1 not only protects telomeres from sister chromatid exchange, but also functions in genome-wide transcriptional regulation and NF-κB-dependent signalling, revealing new perspectives for the telomere field.

    • Laure Crabbe
    •  & Jan Karlseder
  • News & Views |

    The plasma membrane is identified as a source for the formation of autophagosomes, the double membrane vesicles that deliver intracellular components to lysosomes for their degradation.

    • Ana Maria Cuervo

Research Highlights

Articles

  • Article |

    The metabolic enzyme CTP synthase (CtpS) of Caulobacter crescentus can polymerize into cytoskeletal filaments. It functions together with the intermediate filament protein crescentin to control cell shape.

    • Michael Ingerson-Mahar
    • , Ariane Briegel
    • , John N. Werner
    • , Grant J. Jensen
    •  & Zemer Gitai
  • Article |

    Both endoplasmic reticulum and mitochondrial membranes are thought to contribute to the formation of autophagosomes during autophagy induction. We now learn that plasma membrane is also involved, and is partly targeted to the growing autophagosome through clathrin-mediated endocytosis.

    • Brinda Ravikumar
    • , Kevin Moreau
    • , Luca Jahreiss
    • , Claudia Puri
    •  & David C. Rubinsztein
  • Article |

    Mammalian Rap1 protein is found to have a non-telomeric function in regulating the substrate specificity of IKKs towards the p65 subunit of NF-κB, leading to NF-κB transcriptional activity.

    • Hsiangling Teo
    • , Sourav Ghosh
    • , Hendrik Luesch
    • , Arkasubhra Ghosh
    • , Ee Tsin Wong
    • , Najib Malik
    • , Anthony Orth
    • , Paul de Jesus
    • , Anthony S. Perry
    • , Jeffrey D. Oliver
    • , Nhan L. Tran
    • , Lisa J. Speiser
    • , Marc Wong
    • , Enrique Saez
    • , Peter Schultz
    • , Sumit K. Chanda
    • , Inder M. Verma
    •  & Vinay Tergaonkar
  • Article |

    The shelterin complex binds and protects mammalian telomeres. The shelterin component, Rap1, binds to non-telomeric regions and has extra-telomeric functions in transcriptional gene regulation.

    • Paula Martinez
    • , Maria Thanasoula
    • , Ana R. Carlos
    • , Gonzalo Gómez-López
    • , Agueda M. Tejera
    • , Stefan Schoeftner
    • , Orlando Dominguez
    • , David G. Pisano
    • , Madalena Tarsounas
    •  & Maria A. Blasco
  • Article |

    The significance of autophagy for signal transduction has been unclear. Autophagy negatively regulates Wnt signalling by promoting Dishevelled (Dvl) degradation. The von Hippel-Lindau protein ubiquitylates Dvl to faciliatate its recruitment to autophagosomes through p62.

    • Chan Gao
    • , Weipeng Cao
    • , Lan Bao
    • , Wei Zuo
    • , Guoming Xie
    • , Tiantian Cai
    • , Wei Fu
    • , Jian Zhang
    • , Wei Wu
    • , Xu Zhang
    •  & Ye-Guang Chen

Letters

  • Letter |

    In bacteria, chromosomes are partitioned by the Par system. Super-resolution microscopy demonstrates that ParA and ParB forms a 'spindle-like' structure and suggests that the pole protein, TipN, anchors the DNA-bound ParA filaments at the new pole.

    • Jerod L. Ptacin
    • , Steven F. Lee
    • , Ethan C. Garner
    • , Esteban Toro
    • , Michael Eckart
    • , Luis R. Comolli
    • , W.E. Moerner
    •  & Lucy Shapiro
  • Letter |

    During yeast cell division, multidrug resistance (MDR) transporters partition unequally, with the older pool remaining in the mother cell. Mutations in MDR transporter genes reduce replicative lifespan, whereas an extra copy of these genes extends it, suggesting that defective MDR proteins may influence replicative ageing.

    • Amr Eldakak
    • , Giulia Rancati
    • , Boris Rubinstein
    • , Parama Paul
    • , Veronica Conaway
    •  & Rong Li

Corrigendum