Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Exon–intron-fused RAB22A regulates metastasis of osteosarcoma. Liao et al. show that protein products resulting from chromosomal translocations involving RAB22A mediate release of GTP-bound RhoA, induce its activation and promote lung metastasis of osteosarcoma.
Dehapiot et al. show two actin networks at the cell surface in Drosophila embryos. While the pulsatile network controls local deformation, the Frl-dependent persistent network promotes force propagation.
Boyle et al. show that ROCK upregulates PERK signalling in epithelia of breast cancer, thereby enhancing recruitment and function of cancer-associated fibroblasts through CRELD2 to promote tumourigenesis.
Baksh et al. show that oncogenic epidermal stem cells require extracellular serine to initiate squamous cell carcinoma via altering dioxygenases that remove H3K27me3.
Zhang et al. show that dynamin forms a helical structure with actin and, upon disruption, enhances branched actin polymerization, constituting a dynamic cycle to regulate actin cytoskeleton mechanical strength.
Bi et al. reveal a coordinated function for GATA3 and AP1 in altering enhancer landscapes, thereby promoting a basal/mesenchymal phenotype and endocrine resistance in breast cancer.
Adam, Yang et al. show that the transcription factors NFIB and NFIX promote stemness by establishing chromatin accessibility and regulating the super-enhancers that govern bulge stem cell identity.
Fuseya et al. show that HOIL-1L catalyses monoubiquitination on all three LUBAC subunits, thereby impairing the function of LUBAC and its role in infection defence and dermatitis pathogenesis.
Yu, Zhou, Cao, He et al. show that BMP4 reconfigures the nuclear architecture during the transition from primed to naive pluripotency by targeting Zbtb7a and Zbtb7b, which encode proteins that mediate the opening of naive chromatin loci.
Dong, Hao, Zhang, Zhu, Cheng et al. use single-cell RNA sequencing to characterize 28 haematopoietic cell populations and subsequently follow the fate and kinetics of HSCs upon transplantation in the mouse.
Neagu, van Genderen and Escudero et al. show that simultaneous inhibition of WNT and MEK signalling maintains a naive-primed intermediate pluripotency state in vitro, which displays features of the mouse embryonic rosette.
Huang et al. show that, in response to chemotherapy, PTEN directly interacts with NLRP3 in myeloid cells to enhance inflammasome activation and antitumour immune responses.
Li et al. show that hepatocyte-specific loss of Fbp1 in mice leads to steatosis and senescence in hepatic stellate cells, thereby disrupting metabolism and facilitating liver tumorigenesis.
Dawson et al. characterize a macrophage population associated with mammary ducts that are long lived, derive from embryonic precursors and have multiple roles in pregnancy, lactation, involution and cancer.
Three independent but complementary studies by the laboratories of Markus, Reck-Peterson and Yildiz identify a key role for LIS1 in modulating localization, activity and function of dynein in cells.
Lis1 regulates dynein activity. Three independent but complementary studies by the laboratories of Markus, Reck-Peterson and Yildiz identify a key role for Lis1 in modulating localization, activity and function of dynein in cells.
Targeting resistant stem cells in leukaemia, Perry et al. show that doxorubicin at low doses decreases Akt-mediated β-catenin activity, downregulates expression of multiple immune-checkpoint genes and dampens tumorigenesis of leukaemia stem cells.
Park et al. show that Merkel cell polyomavirus upregulates LSD1 activity to repress differentiation genes that can be activated by non-canonical BAF, thereby modulating transformation and tumorigenesis in Merkel cell carcinoma.
Singh et al. show that ELF5 loss disrupts IFNGR1 ubiquitination by FBXW7, thus enhancing IFN-γ signalling, neutrophil accumulation and PD-L1 expression to promote breast cancer progression and metastasis.
Mattout et al. show that the nuclear LSM2-8 complex acts with the exonuclease XRN-2 to degrade transcripts of H3K27me3-marked genes, thus facilitating gene silencing.