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Daneshvar et al. show that BRD3 and the lncRNA DIGIT form phase-separated condensates at genomic regions with H3K18ac to co-regulate the transcription of genes that drive endoderm differentiation.
Here Miceli et al. show that shear stress on primary cilia induces mitochondrial biogenesis and metabolic reprogramming in kidney epithelial cells through lipophagy stimulation.
Moro et al. show that hypermethylation-induced silencing of the ubiquitin ligase FBXL7 rescues c-SRC from ubiquitin-mediated degradation and enhances epithelial-to-mesenchymal transition and metastasis.
Ilina et al. investigate the balance between cell adhesion and matrix density on patterns of collective breast cancer cell invasion using three-dimensional models of the extracellular matrix, in vivo imaging and in silico modelling
Gao et al. uncover p300-induced acetylation and HDAC2-mediated deacetylation of PD-L1, which modulate its nuclear translocation to affect the expression of immune genes and the efficacy of anti-PD-1 therapy.
Aeby et al. report that DCP1A negatively regulates Tsix RNA abundance by suppressing its transcriptional elongation and RNA stability, thus contributing to X-chromosome inactivation.
Nowosad et al. show that during amino acid starvation, the cell-cycle inhibitor p27 binds LAMTOR1 on lysosomes to inhibit mTOR and promote autophagy, linking cell division and cell growth machineries.
Kumar et al. show that mammalian Atg8 proteins along with IRGM regulate the lysosomal system via mTOR and TFEB, respectively, in the response to pathogens.
Mercier et al. demonstrate a role for endosomal membrane tension in modulating ESCRT-III polymerization, intra-lumenal vesicle formation and endosome trafficking.
Profiling phenotype switching in melanoma. Wouters et al. perform large-scale gene expression analysis in patient samples and identify transcriptional networks that modulate the intermediate cell state and ultimate mesenchymal switching in melanoma.
Li et al. report that biophysical properties of AKAP95 protein condensates are essential to its physiological functions in RNA splicing and tumorigenesis.
Dhamija et al. profile 3,412 nonstop mutations from 62 tumour entities and as proof of concept demonstrate that six such mutations cause degradation and loss of the tumour suppressor SMAD4.
After lung injury, Kobayashi, Tata et al. find an intermediate cell state during the transition of alveolar type-2 into type-1 cells that is associated with senescence, controlled by TP53 and persists in fibrosis.
Vietri et al. show that the micronucleus fails to restrain ESCRT-III spreading due to its small size, resulting in aberrant accumulation of ESCRT-III to drive micronuclear collapse and DNA fragmentation.
López-Hernández et al. show that exo-endocytosis of a Na+/H+ exchanger controls lysosome biogenesis through Ca2+/calcineurin-mediated activation of TFEB in response to osmotic stress.
Burton et al. show that H3K9me3 deposition catalysed by SUV39H2 and regulated by pericentromeric RNAs in the mouse paternal pronucleus does not suppress gene expression, but bookmarks promoters for compaction.
Cao et al. show that SPIN90 enhances formation of Arp2/3-mediated unbranched filaments and promotes a formin-based cortex by recruiting mDia1 or forming a ternary SPIN90–Arp2/3–mDia1 complex.
Sheikh et al. show that deficiency in the lysine acetyltransferase MOF causes aberrant accumulation of fatty acids in neural cells, which in turn triggers inflammation in nearby pericytes, resulting in brain haemorrhaging.
Roider et al. combine scRNA-seq and transcriptome-informed flow cytometry, and uncover transcriptionally different malignant subclones with distinct drug responses and T-cell profiles in B-cell non-Hodgkin lymphoma.
Bischof and colleagues report that AP-1 bookmarks prospective senescence enhancers for future activation to achieve a timely execution of the senescence programme.