Volume 38 Issue 8, 1 August 2020

Editorial

Weighing and communicating evidence

As preliminary research findings are shared more widely and at an increasing pace, action is needed to counter the spread of misinformation.

Editorial 30 Jul 2020

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News

Focus shifts to antibody cocktails for COVID-19 cytokine storm

Emerging clinical trial data suggest that individual immunomodulatory drugs can dampen the hyperactive immune system in severe COVID-19, but polytherapy is the way forward.

Charlotte Harrison
News 05 Aug 2020
COVID vaccine results pour in

News in Brief 05 Aug 2020
Histone-writer cancer drugs enter center stage

Epizyme’s EZH2 inhibitor gains two approvals in quick succession — a milestone for this new class of epigenetic cancer drug that targets histone marks with greater precision than previous generations.

Ken Garber
News 05 Aug 2020
Antibacterials get $1 billion injection

News in Brief 05 Aug 2020
High-dose AAV gene therapy deaths

News in Brief 05 Aug 2020
Intercept’s NASH hopes dashed

News in Brief 05 Aug 2020
Around the world in a month

News in Brief 05 Aug 2020
Data Page
- Drug pipeline 2Q20
  
  Laura DeFrancesco
  Data Page 05 Aug 2020
- 2Q20 — Put on a happy face
  
  Laura DeFrancesco
  Data Page 05 Aug 2020
News Feature
- Watcher in the wastewater
  
  Research groups around the globe are looking to see whether urban wastewater monitoring can be integrated into surveillance systems for SARS-CoV-2 and other pathogens.
  
  Charles Schmidt
  News Feature 28 Jul 2020

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Bioentrepreneur

Data Page
- Biotech patenting 2019
  
  Brady Huggett
  Kathryn Paisner
  Bioentrepreneur Data Page 05 Aug 2020

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Correspondence

Surfacing anti-Black science and building antiracist teams

H. Hugo Caicedo
Correspondence 27 Jul 2020
Investing in racial diversity: a call to action to the venture capital community

Jackie Grant
Correspondence 22 Jul 2020
Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Correspondence 18 Jun 2020
Pandemic preparedness in Taiwan

Wei-Kai Wu
Jyh-Ming Liou
Ming-Shiang Wu
Correspondence 23 Jul 2020
Early experience with the FDA’s Breakthrough Devices program

James L. Johnston
Sanket S. Dhruva
Vinay K. Rathi
Correspondence 23 Jul 2020

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Features

Patents
- Federal judge invalidates icosapent ethyl patents — but on the basis of a common statistical mistake
  
  If the decision is allowed to stand, it will have major implications for pharmaceutical patents and biomedical innovation.
  
  Gregory Curfman
  Deepak L. Bhatt
  Michael Pencina
  Patents 05 Aug 2020
- Biomedical imaging
  
  Recent patents related to systems and methods of imaging.
  
  Patents 05 Aug 2020

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News & Views

Podcast
- First Rounders: Ted Love
  
  Podcast 10 Jul 2020
- Forum: CRISPR roundtable with Doudna and Liu
  
  Podcast 14 Jul 2020

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Research

Brief Communications
- Plants with genetically encoded autoluminescence
  
  Luminescence is engineered in whole plants, without an exogenous substrate, using a fungal gene cluster.
  
  Tatiana Mitiouchkina
  Alexander S. Mishin
  Karen S. Sarkisyan
  Brief Communication 27 Apr 2020
Letters
- Human chimeric antigen receptor macrophages for cancer immunotherapy
  
  Primary macrophages engineered to express chimeric antigen receptors have anti-tumor activity in humanized mice.
  
  Michael Klichinsky
  Marco Ruella
  Saar Gill
  
  Collection:
  
  25th Anniversary Collection
  Letter 23 Mar 2020
- Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
  
  Single-cell CRISPR screens are readily multiplexed and scaled with an improved version of Perturb-seq.
  
  Joseph M. Replogle
  Thomas M. Norman
  Britt Adamson
  Letter 30 Mar 2020
- Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron
  
  A platform for genetic circuit design in a human gut commensal bacterium brings microbiome therapies that respond to gastrointestinal signals a step closer.
  
  Mao Taketani
  Jianbo Zhang
  Christopher A. Voigt
  Letter 30 Mar 2020
Articles
- COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
  
  Single-cell analysis of COVID-19 patient samples identifies activated immune pathways that correlate with severe disease.
  
  Robert Lorenz Chua
  Soeren Lukassen
  Roland Eils
  Article 26 Jun 2020
- Sci-fate characterizes the dynamics of gene expression in single cells
  
  Gene expression dynamics in single cells are tracked by labeling newly synthesized RNA in indexed cells.
  
  Junyue Cao
  Wei Zhou
  Jay Shendure
  Article 13 Apr 2020
- Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase–tRNA pairs
  
  Orthogonal aminoacyl-tRNA synthetase–tRNA pairs are discovered by analyzing millions of sequences.
  
  Daniele Cervettini
  Shan Tang
  Jason W. Chin
  Article 13 Apr 2020

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Amendments & Corrections

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Author Correction 17 Jul 2020
Author Correction: Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations

Jacob E. Crawford
David W. Clarke
Bradley J. White
Author Correction 24 Jul 2020
Author Correction: Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron

Mao Taketani
Jianbo Zhang
Christopher A. Voigt
Author Correction 07 May 2020
Author Correction: Plants with genetically encoded autoluminescence

Tatiana Mitiouchkina
Alexander S. Mishin
Karen S. Sarkisyan
Author Correction 04 Jun 2020
Publisher Correction: The hothouse for protein design

Caroline Seydel
Publisher Correction 22 Jul 2020

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Careers & Recruitment

Career Feature
- Second-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 05 Aug 2020
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 05 Aug 2020

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Volume 38 Issue 8, 1 August 2020

CAR macrophages

Editorial

News

Data Page

News Feature

Bioentrepreneur

Data Page

Correspondence

Features

Patents

News & Views

Podcast

Research

Brief Communications

Letters

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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