Potent siRNA silencing in the brain
High-resolution image of the primate dentate gyrus, a structure in the hippocampus, showing neurons (green), glia (purple), cell nuclei (blue) and divalent siRNAs (Di-siRNA, red). Alterman et al. demonstrate that Di-siRNAs distribute broadly in the brains of mice and non-human primates and enable potent and persistent gene silencing.
See Alterman et al.