Volume 32 Issue 4, April 2014

Volume 32 Issue 4

New mouse models of human immunity will enable a variety of research and clinical applications (p 335). Humanized mice described by Rongvaux et al. (p 364) can be used to study the influence of human immune cells on disease pathology and response to therapy. The mice presented by Lee et al. (p 356) may be used to evaluate the efficacy of candidate vaccines, and to rapidly produce human antibodies having high affinity for therapeutic targets. Credit: © tiripero iStock.

Editorial

  • Editorial |

    CRISPR-Cas is about to transform how we interrogate genetic variants and model disease.

News

Data Page

News Feature

  • News Feature |

    Ease of use, economy and speed of targeting DNA has propelled the CRISPR-Cas system into the spotlight. Now, despite numerous gaps in our knowledge, commercial entities are looking for a piece of the action. Monya Baker reports.

Bioentrepreneur

Correspondence

Feature

  • Feature |

    As of last month, 41 products have been granted breakthrough therapy designations by the US Food and Drug Administration—drugs against cancer, hepatitis C and monogenetic diseases predominate.

    • Saurabh (Rob) Aggarwal

Patents

News & Views

  • News & Views |

    A nanoparticle that senses reactive oxygen and nitrogen species in the liver should improve in vivo detection of cellular stress.

    • Jefferson Chan
    •  & Christopher J Chang
  • News & Views |

    Structural and biochemical studies elucidate DNA targeting by the Cas9 endonuclease.

    • Erin L Garside
    •  & Andrew M MacMillan

Analysis

Review Article

Article

  • Article |

    Mice engineered to express the entire human variable immunoglobulin region enable rapid isolation of high-affinity antibodies specific for antigens of interest.

    • E-Chiang Lee
    • , Qi Liang
    • , Hanif Ali
    • , Luke Bayliss
    • , Alastair Beasley
    • , Tara Bloomfield-Gerdes
    • , Laura Bonoli
    • , Richard Brown
    • , Jamie Campbell
    • , Adam Carpenter
    • , Sara Chalk
    • , Alison Davis
    • , Nick England
    • , Alla Fane-Dremucheva
    • , Bettina Franz
    • , Volker Germaschewski
    • , Helen Holmes
    • , Steve Holmes
    • , Ian Kirby
    • , Miha Kosmac
    • , Anais Legent
    • , Hui Lui
    • , Anais Manin
    • , Siobhan O'Leary
    • , Jemima Paterson
    • , Rocco Sciarrillo
    • , Anneliese Speak
    • , Dominik Spensberger
    • , Laura Tuffery
    • , Nikole Waddell
    • , Wei Wang
    • , Sophie Wells
    • , Vivian Wong
    • , Andrew Wood
    • , Michael J Owen
    • , Glenn A Friedrich
    •  & Allan Bradley
  • Article |

    A mouse bearing multiple human cytokine genes enables in vivo development and function of various human innate immune cell types.

    • Anthony Rongvaux
    • , Tim Willinger
    • , Jan Martinek
    • , Till Strowig
    • , Sofia V Gearty
    • , Lino L Teichmann
    • , Yasuyuki Saito
    • , Florentina Marches
    • , Stephanie Halene
    • , A Karolina Palucka
    • , Markus G Manz
    •  & Richard A Flavell

Letter

Careers and Recruitment