Volume 32 Issue 12, December 2014

Volume 32 Issue 12

Artist’s impression of an SATE - modified siRNA in the process of being deprotected by cellular thioesterases after entering the cytosol (p 1256). Credit: Peter Allen, UCSB College of Engineering

Editorial

  • Editorial |

    Mandatory labeling of GM food in the United States will not only make all food more costly but also bamboozle consumers.

News

News Feature

  • News Feature |

    As US legislatures and voters continue to wrestle with GM labeling, what is at stake? Jim Kling investigates.

    • Jim Kling

Bioentrepreneur

Correspondence

Patents

  • Patents |

    Recent developments in the prosecution of the CRISPR-Cas9 patent in Europe highlight the differences between the intellectual property regimes of Europe and the United States.

    • András Kupecz

News & Views

  • News & Views |

    Delivery of siRNA into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversible manner.

    • Anastasia Khvorova
    • , Maire F Osborn
    •  & Matthew R Hassler
  • News & Views |

    A new biological device known as a 'load driver' improves the performance of synthetic circuits by insulating genetic parts from each other.

    • Eric Klavins

Analysis

  • Analysis |

    A community of researchers report the lessons learned from applying 44 algorithms to predict drug sensitivity in cancer cell lines using genomic, epigenetic and proteomic datasets

    • James C Costello
    • , Laura M Heiser
    • , Elisabeth Georgii
    • , Mehmet Gönen
    • , Michael P Menden
    • , Nicholas J Wang
    • , Mukesh Bansal
    • , Muhammad Ammad-ud-din
    • , Petteri Hintsanen
    • , Suleiman A Khan
    • , John-Patrick Mpindi
    • , Olli Kallioniemi
    • , Antti Honkela
    • , Tero Aittokallio
    • , Krister Wennerberg
    • , Jean-Paul Abbuehl
    • , Tero Aittokallio
    • , Jeffrey Allen
    • , Russ B Altman
    • , Muhammad Ammad-ud-din
    • , Shawn Balcome
    • , Mukesh Bansal
    • , Alexis Battle
    • , Andreas Bender
    • , Bonnie Berger
    • , Jonathan Bernard
    • , Madhuchhanda Bhattacharjee
    • , Krithika Bhuvaneshwar
    • , Andrew A Bieberich
    • , Fred Boehm
    • , Andrea Califano
    • , Christina Chan
    • , Beibei Chen
    • , Ting-Huei Chen
    • , Jaejoon Choi
    • , Luis Pedro Coelho
    • , Thomas Cokelaer
    • , James C Collins
    • , James C Costello
    • , Chad J Creighton
    • , Jike Cui
    • , Will Dampier
    • , V Jo Davisson
    • , Bernard De Baets
    • , Raamesh Deshpande
    • , Barbara DiCamillo
    • , Murat Dundar
    • , Zhana Duren
    • , Adam Ertel
    • , Haoyang Fan
    • , Hongbin Fang
    • , Dan Gallahan
    • , Robinder Gauba
    • , Elisabeth Georgii
    • , Mehmet Gönen
    • , Assaf Gottlieb
    • , Michael Grau
    • , Joe W Gray
    • , Yuriy Gusev
    • , Min Jin Ha
    • , Leng Han
    • , Michael Harris
    • , Laura M Heiser
    • , Nicholas Henderson
    • , Hussein A Hejase
    • , Petteri Hintsanen
    • , Krisztian Homicsko
    • , Antti Honkela
    • , Jack P Hou
    • , Woochang Hwang
    • , Adriaan P IJzerman
    • , Olli Kallioniemi
    • , Bilge Karacali
    • , Samuel Kaski
    • , Sunduz Keles
    • , Christina Kendziorski
    • , Suleiman A Khan
    • , Junho Kim
    • , Min Kim
    • , Youngchul Kim
    • , David A Knowles
    • , Daphne Koller
    • , Junehawk Lee
    • , Jae K Lee
    • , Eelke B Lenselink
    • , Biao Li
    • , Bin Li
    • , Jun Li
    • , Han Liang
    • , Jian Ma
    • , Subha Madhavan
    • , Michael P Menden
    • , Sean Mooney
    • , John-Patrick Mpindi
    • , Chad L Myers
    • , Michael A Newton
    • , John P Overington
    • , Ranadip Pal
    • , Jian Peng
    • , Richard Pestell
    • , Robert J Prill
    • , Peng Qiu
    • , Bartek Rajwa
    • , Anguraj Sadanandam
    • , Julio Saez-Rodriguez
    • , Francesco Sambo
    • , Hyunjin Shin
    • , Dinah Singer
    • , Jiuzhou Song
    • , Lei Song
    • , Arvind Sridhar
    • , Michiel Stock
    • , Gustavo Stolovitzky
    • , Wei Sun
    • , Tram Ta
    • , Mahlet Tadesse
    • , Ming Tan
    • , Hao Tang
    • , Dan Theodorescu
    • , Gianna Maria Toffolo
    • , Aydin Tozeren
    • , William Trepicchio
    • , Nelle Varoquaux
    • , Jean-Philippe Vert
    • , Willem Waegeman
    • , Thomas Walter
    • , Qian Wan
    • , Difei Wang
    • , Nicholas J Wang
    • , Wen Wang
    • , Yong Wang
    • , Zhishi Wang
    • , Joerg K Wegner
    • , Krister Wennerberg
    • , Tongtong Wu
    • , Tian Xia
    • , Guanghua Xiao
    • , Yang Xie
    • , Yanxun Xu
    • , Jichen Yang
    • , Yuan Yuan
    • , Shihua Zhang
    • , Xiang-Sun Zhang
    • , Junfei Zhao
    • , Chandler Zuo
    • , Herman W T van Vlijmen
    • , Gerard J P van Westen
    • , James J Collins
    • , Dan Gallahan
    • , Dinah Singer
    • , Julio Saez-Rodriguez
    • , Samuel Kaski
    • , Joe W Gray
    •  & Gustavo Stolovitzky
  • Analysis |

    A community computational challenge generates algorithms to predict activity of drug combinations.

    • Mukesh Bansal
    • , Jichen Yang
    • , Charles Karan
    • , Michael P Menden
    • , James C Costello
    • , Hao Tang
    • , Guanghua Xiao
    • , Yajuan Li
    • , Jeffrey Allen
    • , Rui Zhong
    • , Beibei Chen
    • , Minsoo Kim
    • , Tao Wang
    • , Laura M Heiser
    • , Ronald Realubit
    • , Michela Mattioli
    • , Mariano J Alvarez
    • , Yao Shen
    • , Jean-Paul Abbuehl
    • , Jeffrey Allen
    • , Russ B Altman
    • , Shawn Balcome
    • , Mukesh Bansal
    • , Ana Bell
    • , Andreas Bender
    • , Bonnie Berger
    • , Jonathan Bernard
    • , Andrew A Bieberich
    • , Giorgos Borboudakis
    • , Andrea Califano
    • , Christina Chan
    • , Beibei Chen
    • , Ting-Huei Chen
    • , Jaejoon Choi
    • , Luis Pedro Coelho
    • , James C Costello
    • , Chad J Creighton
    • , Will Dampier
    • , V Jo Davisson
    • , Raamesh Deshpande
    • , Lixia Diao
    • , Barbara Di Camillo
    • , Murat Dundar
    • , Adam Ertel
    • , Cellworks Group
    • , Daniel Gallahan
    • , Chirayu P Goswami
    • , Assaf Gottlieb
    • , Michael N Gould
    • , Jonathan Goya
    • , Michael Grau
    • , Joe W Gray
    • , Laura M Heiser
    • , Hussein A Hejase
    • , Michael F Hoffmann
    • , Krisztian Homicsko
    • , Max Homilius
    • , Woochang Hwang
    • , Adriaan P Ijzerman
    • , Olli Kallioniemi
    • , Bilge Karacali
    • , Charles Karan
    • , Samuel Kaski
    • , Junho Kim
    • , Minsoo Kim
    • , Arjun Krishnan
    • , Junehawk Lee
    • , Young-Suk Lee
    • , Eelke B Lenselink
    • , Peter Lenz
    • , Lang Li
    • , Jun Li
    • , Yajuan Li
    • , Han Liang
    • , Michela Mattioli
    • , Michael P Menden
    • , John-Patrick Mpindi
    • , Chad L Myers
    • , Michael A Newton
    • , John P Overington
    • , Juuso Parkkinen
    • , Robert J Prill
    • , Jian Peng
    • , Richard Pestell
    • , Peng Qiu
    • , Bartek Rajwa
    • , Ronald Realubit
    • , Anguraj Sadanandam
    • , Julio Saez-Rodriguez
    • , Francesco Sambo
    • , Dinah Singer
    • , Gustavo Stolovitzky
    • , Arvind Sridhar
    • , Wei Sun
    • , Hao Tang
    • , Gianna M Toffolo
    • , Aydin Tozeren
    • , Olga G Troyanskaya
    • , Ioannis Tsamardinos
    • , Herman W T van Vlijmen
    • , Tao Wang
    • , Wen Wang
    • , Joerg K Wegner
    • , Krister Wennerberg
    • , Gerard J P van Westen
    • , Tian Xia
    • , Guanghua Xiao
    • , Yang Xie
    • , Jichen Yang
    • , Yang Yang
    • , Victoria Yao
    • , Yuan Yuan
    • , Haoyang Zeng
    • , Shihua Zhang
    • , Junfei Zhao
    • , Jian Zhou
    • , Rui Zhong
    • , Daniel Gallahan
    • , Dinah Singer
    • , Julio Saez-Rodriguez
    • , Yang Xie
    • , Gustavo Stolovitzky
    •  & Andrea Califano

Article

Letter

  • Letter | | Open Access

    The genome sequence of the ferret, a model of human respiratory disease, enables research on influenza and cystic fibrosis.

    • Xinxia Peng
    • , Jessica Alföldi
    • , Kevin Gori
    • , Amie J Eisfeld
    • , Scott R Tyler
    • , Jennifer Tisoncik-Go
    • , David Brawand
    • , G Lynn Law
    • , Nives Skunca
    • , Masato Hatta
    • , David J Gasper
    • , Sara M Kelly
    • , Jean Chang
    • , Matthew J Thomas
    • , Jeremy Johnson
    • , Aaron M Berlin
    • , Marcia Lara
    • , Pamela Russell
    • , Ross Swofford
    • , Jason Turner-Maier
    • , Sarah Young
    • , Thibaut Hourlier
    • , Bronwen Aken
    • , Steve Searle
    • , Xingshen Sun
    • , Yaling Yi
    • , M Suresh
    • , Terrence M Tumpey
    • , Adam Siepel
    • , Samantha M Wisely
    • , Christophe Dessimoz
    • , Yoshihiro Kawaoka
    • , Bruce W Birren
    • , Kerstin Lindblad-Toh
    • , Federica Di Palma
    • , John F Engelhardt
    • , Robert E Palermo
    •  & Michael G Katze
  • Letter |

    Neutralizing the RNA phosphodiester backbone enables delivery of siRNA across cell membranes.

    • Bryan R Meade
    • , Khirud Gogoi
    • , Alexander S Hamil
    • , Caroline Palm-Apergi
    • , Arjen van den Berg
    • , Jonathan C Hagopian
    • , Aaron D Springer
    • , Akiko Eguchi
    • , Apollo D Kacsinta
    • , Connor F Dowdy
    • , Asaf Presente
    • , Peter Lönn
    • , Manuel Kaulich
    • , Naohisa Yoshioka
    • , Edwige Gros
    • , Xian-Shu Cui
    •  & Steven F Dowdy
  • Letter |

    Analysis of the genome editing activity of more than 1800 sgRNAs in mouse and human cells yields rules to facilitate design of highly active RNA guides for Cas-9 genome editing.

    • John G Doench
    • , Ella Hartenian
    • , Daniel B Graham
    • , Zuzana Tothova
    • , Mudra Hegde
    • , Ian Smith
    • , Meagan Sullender
    • , Benjamin L Ebert
    • , Ramnik J Xavier
    •  & David E Root
  • Letter |

    An orthogonal protein degradation system in bacteria provides control of both protein concentration and the protein degradation rate.

    • D Ewen Cameron
    •  & James J Collins

Careers and Recruitment

  • Careers and Recruitment |