Volume 23 Issue 5, May 2005

Volume 23 Issue 5

An unstained brain section from an APP23 transgenic mouse, an animal model of Alzheimer disease. Amyloid plaques are visible as small dark dots, most of them in the neocortex. Hintersteiner et al. describe a new probe for imaging amyloid plaques in living mice (p 577).



Opinion and Comment


  • Feature |

    Population genetics research collaborations are reaching increasingly across national boundaries to access human tissue repositories. Will discrepancies in national policies on informed consent and IP rights hinder progress?

    • Karen J Maschke
  • Patents

News and Views

  • News & Views |

    AAV vectors containing the combined furin-site and 2A 'self-cleaving' peptide facilitate high-level expression of monoclonal antibodies in vivo.

    • Wayne A Marasco
  • News & Views |

    Amyloid deposits can be rapidly detected in the brains of living mice using a novel ligand and near-infrared fluorescence imaging.

    • Todd E Golde
    •  & Brian J Bacskai
  • News & Views |

    An information theoretic algorithm that prunes away potentially indirect interactions allows for improved reconstruction of biological networks.

    • Alexander J Hartemink
  • News & Views |

    A recent Keystone meeting highlighted the progress in generating effective anti-cancer antibodies by manipulating antibody binding affinity and their ability to support ADCC.

    • Louis M Weiner
    •  & Paul Carter

Computational Biology