Can methylation be the key to challenging the interpretation of existing gene patent claims? And can a novel PCR method be used to enable the sequencing of hundreds of genes?
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References
Salzberg, S.L. Clin. Pharmacol. Ther. 91, 969–971 (2012).
Association for Molecular Pathology vs. Myriad Genetics, Inc. et al. 569 US ____ (2013).
Jensen, K. & Murray, F. Science 310, 239–240 (2005).
Holman, C.M. Nat. Biotechnol. 30, 240–244 (2012).
Rosenfeld, J.A. & Mason, C.E. Genome Med. 5, 27 (2013).
Graff, G.D. et al. Nat. Biotechnol. 31, 404–410 (2013).
Anonymous. Nature 464, 649–650 (2010).
Christensen, C.M. The Innovator's Dilemma: When New Technologies Cause Great Firms to Fail (Harvard Business School Press, Boston, 1997).
Anonymous. Technical information and test overview. (Foundation Medicine, 2012). http://www.foundationone.com/order-foundationone/ONE-I-002-20130529_FoundationOne_Technical.pdf
Teutsch S. et al. Gene Patents and Licensing Practices and Their Impact on Patient Access to Genetic Tests (Secretary's Advisory Committee on Genetics, Health, and Society, US Department of Health and Human Services, April 2010).
Lander, E.S. Brief for amicus curiae in support of neither party (2013).
Chiu, R.W. et al. Clin. Chem. 56, 459–463 (2010).
Association for Molecular Pathology vs USPTO. No. 2010–1406 (Fed. Cir. Aug. 16, 2012).
Clark, T.A. et al. Nucleic Acids Res. 40, e29 (2012).
Flusberg, B.A. et al. Nat. Methods 7, 461–465 (2010).
Holliday, R. & Ho, T. Somat. Cell Mol. Genet. 21, 215–218 (1995).
Holliday, R. & Ho, T. Somat. Cell Mol. Genet. 17, 537–542 (1991).
Holliday, R. & Ho, T. Proc. Natl. Acad. Sci. USA 95, 8727–8732 (1998).
Cantara, W.A. et al. Proc. Natl. Acad. Sci. USA 110, 10964–10969 (2013).
Fraiser, M.S. et al. Decontamination of nucleic acid amplification reactions using uracil-N-glycosylase (UDG) (1993).
Horton, J.R. et al. Nucleic Acids Res. 40, 9763–9773 (2012).
Wardle, J. et al. Nucleic Acids Res. 36, 705–711 (2008).
Johansson, H. et al. Nucleic Acids Res. 39, e8 (2011).
Schiffman, J.D. et al. Cancer Genet. Cytogenet. 193, 9–18 (2009).
Wong, K.K. & McClelland, M. Nucleic Acids Res. 19, 1081–1085 (1991).
Langmead, B. et al. Genome Biol. 10, R25 (2009).
Quinlan, A.R. & Hall, I.M. Bioinformatics 26, 841–842 (2010).
McKenna, A. et al. Genome Res. 20, 1297–1303 (2010).
Kozarewa, I. et al. Nat. Methods 6, 291–295 (2009).
Valouev, A. et al. Genome Res. 18, 1051–1063 (2008).
Aird, D. et al. Genome Biol. 12, R18 (2011).
Cohen-Karni, D. et al. Proc. Natl. Acad. Sci. USA 108, 11040–11045 (2011).
Lo, Y.M.D. et al. Methods for detecting fetal DNA in a plasma or serum sample from a pregnant woman (2006).
Champlot, S. et al. PLoS ONE 5, e13042 (2010).
Wagner, I. & Capesius, I. Biochim. Biophys. Acta 654, 52–56 (1981).
Rothbard, M.N. Man, Economy, and State; a Treatise on Economic Principles (Van Nostrand, Princeton, NJ, 1962).
Hayek, F.A. Monetary Theory and the Trade Cycle (A.M. Kelley, 1966).
Schauinger, S. The Human Gene Patent Report http://hgpr.org/finalHGPR.pdf (2012).
Pollack, R. Signs of Life: the Language and Meanings of DNA (Houghton Mifflin, Boston, 1994).
Acknowledgements
We would like to thank C. Gunter, T. Harkins, S. Grimmond and R. McKernan for valuable editorial advice. We would like to thank E. Dimalantis for constructive discussions regarding MspJI.
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The authors are employed by Courtagen Life Sciences, which is a CLIA and CAP-certified next-generation DNA sequencing facility. The company sequences gene panels and exomes of children with mitochondrial disease, epilepsy and autism. The opinions expressed by the authors on gene patents are their own and may not reflect those of Courtagen.
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McKernan, K., Spangler, J., Helbert, Y. et al. DREAMing of a patent-free human genome for clinical sequencing. Nat Biotechnol 31, 884–887 (2013). https://doi.org/10.1038/nbt.2703
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DOI: https://doi.org/10.1038/nbt.2703
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