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Altered gene expression in tumors has been explored as a prognostic indicator of cancer outcome and treatment efficacy. Taylor et al. extend this approach by analyzing the coordinated expression of 'hub' proteins and their interacting partners as a means of predicting breast cancer prognosis.
Werbowetski-Ogilvie et al. show that cultured human embryonic stem (hES) cells that appear normal may in fact be partially transformed. Two such lines are found to have aberrant growth and differentiation properties and submicroscopic chromosomal abnormalities.
