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In the ascendant world of mRNA medicines, circular RNA shows promise as an alternative way for making proteins inside human cells.

The biotech sector must devote more resources to cybersecurity — especially those companies that are manufacturers of essential medical products.

Improving target selectivity and defining cell phenotypes may improve the odds of finding therapies for fibrosis.

This study reveals a high level of behavioral heterogeneity in engineered T cells that target tumor organoids. Behavior-guided transcriptomics identified the gene signatures of T cells with highly potent serial cytotoxicity. Integration of the organoid and T cell transcriptomic data enabled the design of patient-specific combinatorial treatment to achieve an optimized response to cancer immunotherapies.

Logic-gated monoclonal antibodies have been designed to improve safety and efficacy.

Cancers with common KRAS mutations can be treated with an inhibitor of lysosomal acidification in mice.

Antibody pairs are made to act selectively on cells co-expressing two targets by engineering their Fc domains.

The dynamics and molecular mechanisms of T cell therapies are probed in cancer organoids.

An influenza vaccine is created by attenuating the live virus through targeted proteolysis.

Genomic surveillance is important for pandemic preparedness. By deep sequencing of wastewater samples, we monitored the genetic dynamics of circulating SARS-CoV-2 virus variants in Austria from December 2020 to February 2022. We show how wastewater-based epidemiology enables robust quantification of viral spatiotemporal dynamics as well as the detection of emergent new variants.

Multiple variants of SARS-CoV-2 are inhibited by a trispecific DARPin.

Many biomedical questions demand scalable, deep, and accurate proteome analysis of small samples, including single cells. A scalable framework of multiplexed data-independent acquisition for mass spectrometry enables time saving by parallel analysis of both peptide ions and protein samples, thereby realizing multiplicative gains in throughput.

Protein expression from circular RNAs is enhanced several hundred-fold by optimizing vector design.

Wastewater surveillance of SARS-CoV-2 at the national scale tracks emerging variants.

Proteomics of small sample sizes using data-independent acquisition methods achieves higher throughput with multiplexing.