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Generative AI is moving full speed ahead in the biomedical space.

Pfizer created a ‘light-speed’ approach to meet the challenge of vaccinating the world against COVID-19. It involved developing new strategies for all aspects of vaccine development, from sourcing materials and scaling up manufacturing to transportation and dosing.

Synapse-tuned CAR immune cells effectively kill solid tumor cells.

Ultrasensitive sequential fluorescence in situ hybridization (USeqFISH) enables multiplexed detection of the expression of endogenous and exogenous genes delivered by adeno-associated virus (AAV) vectors in intact tissue. USeqFISH provides a spatial map of AAV tropism with high throughput and resolution.

Functional proteins with limited homology to natural proteins are designed using a large language model.

CLASH is a CRISPR-based platform that enables the parallel knock-in via homology-directed repair of a large pool of transgene variants encoded in adeno-associated virus vectors. CLASH can be applied to the systematic and unbiased selection of favorable features in T cells and, in principle, other cell types.

Human intestinal organoids are endowed with immune cells by transplantation into humanized mice.

Zinc finger design is facilitated with a deep-learning model.

Dual mapping shows localization patterns of AAV and RNA in intact tissues.

Unbiased selection of CAR-T cells is achieved by massively parallel knock-in engineering.

A generative deep-learning model designs artificial proteins with desired enzymatic activities.

Enhanced axial resolution for 3D SIM is achieved with deep learning or four-beam interference.

Targeted RNA degradation remains a challenge using existing methods owing to off-target effects and toxicity. We adapted the CRISPR-Csm complex, a multi-protein effector from type III CRISPR systems, for precise knockdown of nuclear or cytoplasmic transcripts in eukaryotic cells with minimal side effects.

How small molecules bind chromatin and DNA is determined by Chem-map.

The bacterial Csm complex efficiently knocks down eukaryotic nuclear and cytoplasmic RNAs.

A bacterium expressing antibacterial genes treats a lung infection associated with mechanical ventilators.

A muscle autoimmune disease is treated in mice with CAAR T cells.

A resource of microbial metabolic models reveals how an individual’s gut microbiome influences drug metabolism.