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Volume 551 Issue 7679, 9 November 2017

Outlook

  • Outlook |

    The diagnostics, treatment and five-year survival rates for bladder cancer are largely unchanged since the 1990s. Research into cancer genomics, risk factors and immune therapies could hold the key to progress against this malignant disease.

    • Chris Berdik

    Nature Outlook:

  • Outlook |

    People with metastatic bladder cancer once faced meagre treatment options and a grim prognosis. But immunotherapy has started to yield results.

    • Michael Eisenstein

    Nature Outlook:

  • Outlook |

    Once thought to be sterile, the bladder contains microbes that could influence the development and treatment of cancer.

    • Claire Ainsworth

    Nature Outlook:

  • Outlook |

    What happens when a professor of theatre finds out she has bladder cancer? She writes a one-woman play about it, of course.

    • Tammy Worth

    Nature Outlook:

  • Outlook |

    Mechele Leon, an associate professor of theatre at the University of Kansas in Lawrence, was diagnosed with bladder cancer in March 2016. After treatment, Leon was left with no bladder, a urostomy bag, and a story to tell — which became a one-woman play called Bladder Interrupted.

    • Tammy Worth

    Nature Outlook:

  • Outlook |

    Researchers delving into the details of bladder cancer are finding a rich trove of genetic information.

    • Jeanne Erdmann

    Nature Outlook:

  • Outlook |

    Tackling the challenges of genomics and studies of the immune system should help to create much-needed diagnostics and treatments.

    • Chris Berdik

    Nature Outlook:

Spotlight

Editorial

Seven Days

News

News Feature

Comment

Books & Arts

  • Books & Arts |

    Barbara Kiser reviews five of the week's best science picks.

    • Andrew Robinson

News & Views

  • News & Views |

    A silicon probe that is inserted into the mouse brain can precisely measure the activity of about 200 individual neurons simultaneously. This tool should improve our ability to study functional neuronal circuitry. See Letter p.232

    • Edward M. Callaway
    • Anupam K. Garg
  • News & Views |

    An event that initially resembled an ordinary supernova explosion continued to erupt brightly for more than 600 days. Standard theoretical models cannot explain the event's properties. See Letter p.210

    • Stan Woosley
  • News & Views |

    Circulation of the ocean's densest waters modulates millennial-scale shifts in climate. Contrary to conventional wisdom, a study finds that the shape of the sea floor constrains where these waters rise towards the surface. See Article p.181

    • Andrew L. Stewart
  • News & Views |

    Genetic variation in a neuropeptide signalling pathway regulates age-related declines in health in nematode worms. This discovery points to a mechanism that influences individual differences in ageing. See Article p.198

    • Patrick T. McGrath
  • News & Views |

    The presence of N1 methyl groups on adenine bases was thought to be widespread in messenger RNAs. It now seems that these modifications are much less prevalent, and occur on mRNAs that structurally mimic transfer RNA. See Letter p.251

    • Anya V. Grozhik
    • Samie R. Jaffrey
  • News & Views |

    Small-molecule organic dyes that fluoresce in the short-wave infrared region of the spectrum could improve the resolution of in vivo bioimaging methods. Such dyes have now been made by adapting those that fluoresce visible light.

    • Martin J. Schnermann

Letter

  • Letter |

    Nutrient amendment experiments at the boundary of the South Atlantic gyre reveal extensive regions in which nitrogen and iron are co-limiting, with other micronutrients also approaching co-deficiency; such limitations potentially increase phytoplankton community diversity.

    • Thomas J. Browning
    • Eric P. Achterberg
    • C. Mark Moore
  • Letter |

    In copper components containing highly oriented nanotwins, correlated ‘necklace’ dislocations moving back and forth offer an unusually fatigue-resistant response to engineering stress.

    • Qingsong Pan
    • Haofei Zhou
    • Lei Lu
  • Letter |

    Stacking-disordered ice crystallites are shown to have an ice nucleation rate much higher than predicted by classical nucleation theory, which needs to be taken into account in cloud modelling.

    • Laura Lupi
    • Arpa Hudait
    • Valeria Molinero
  • Letter |

    Analyses of digital corpora of annotated texts reveal the influence of stochastic drift versus selection in grammatical shifts in English and provide a general method for quantitatively testing theories of language change.

    • Mitchell G. Newberry
    • Christopher A. Ahern
    • Joshua B. Plotkin
  • Letter |

    Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential therapeutic target for neuropsychiatric disorders associated with copy-number variants that include KCTD13.

    • Christine Ochoa Escamilla
    • Irina Filonova
    • Craig M. Powell
  • Letter |

    The discovery of a visual-looming-sensitive neuron, LPLC2, that provides input to the Drosophila escape pathway, and uses dendrites patterned to integrate directionally selective inputs to selectively encode outward motion.

    • Nathan C. Klapoetke
    • Aljoscha Nern
    • Gwyneth M. Card

Erratum

Article

Feature

  • Feature |

    Scientists are as sceptical as they come — but many still engage in personal rituals or use totems in the lab and field.

    • Kendall Powell

Column

  • Column |

    We need a new normal for women, says Shari L. Gallop

    • Shari L. Gallop
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