Reviews & Analysis

To counter misinformation, people are often advised to check the truth of claims by searching online. Five experiments show that this can actually increase people’s belief that false or misleading articles are true, an effect that might be driven by low-quality search results.

An artificial-intelligence graph neural network was trained on experimental data and used to identify chemical substructures that underlie selective antibiotic activity in more than 12 million compounds. This led to the discovery of a class of antibiotics with in vitro and in vivo activity against Gram-positive bacteria, including Staphylococcus aureus.

Medium- and high-entropy alloys are hugely promising materials in metallurgy and catalysis, but their atomic-scale structure — and how that relates to their properties — is not well understood. A powerful method is beginning to reveal their secrets, with hopes for engineering better materials in the future.

Thin cellular protrusions called cytonemes can transport ligand–receptor complexes from a signal-producing cell to a receiving cell in the developing zebrafish embryo. Even cells lacking the receptor can be activated by this signalling system.

Progression into the final phase of the cell cycle is driven mainly by protein phosphorylation, although it also requires the inhibition of phosphatase proteins, such as the PP2A:B55 complex. The structures reveal how PP2A:B55 binds to two of its inhibitors.

The strength of the biological carbon pump was estimated using direct measurements of nutrients collected over decades. The findings indicate that ocean waters can capture and store larger amounts of carbon dioxide than previously estimated. This might have implications for climate-change models.

Linking biological tissues with electronic devices is challenging owing to the softness of tissues and their arbitrary shapes and sizes. An innovative water-responsive, supercontractile polymer film, inspired by spider silk, allows the construction of soft, stretchable and shape-adaptive tissue–electronic interfaces.

The hormone oxytocin is secreted by the brain during labour and lactation. It has also been associated with lipid release from intracellular stores, but the physiological implications of this were unknown. This study shows that oxytocin is produced locally by neurons that innervate the adipose tissue and is required for maximizing energy release from fat.

Diabetes is a strong risk factor for viral respiratory infections, including influenza and COVID-19, which can be particularly dangerous for people with the condition. The discovery that the metabolism of lung dendritic cells, key sentinels of the immune system, is disrupted by high blood-sugar levels could provide a route to reversing this susceptibility.

Electron spin resonance is a standard method for studying the structure of chemical compounds, and it can also be used to control quantum spin states. Combining electron spin resonance with atomic force microscopy allows single spins to be manipulated in single molecules — with potential applications in quantum computing and elsewhere.

Analysis of a massive genomic data set reveals the profound effects that the movement of Bantu-speaking peoples had on Africa’s biological, linguistic and cultural landscape. These findings provide valuable insights for a wide range of disciplines and serve as a comprehensive data set of ancient and modern African individuals for comparative studies.

By comparing DNA sequences across hundreds of species of primates and other mammals, an analysis identifies non-coding regulatory elements that are conserved only in primates and that could have important roles in complex traits and diseases in humans.

A series of structures of the eukaryotic protein-synthesis machinery are imaged at high resolution in defined states of the elongation phase of protein synthesis. Analysis suggests that there are underlying molecular mechanisms that increase the accuracy of translation of genetic information in eukaryotes.

There is a long-standing assumption that large, densely populated cities inherently foster interactions between a diverse range of people. Analysis of 1.6 billion person-to-person encounters in the United States reveals that big cities are actually pockets of extreme segregation, highlighting a need for strategic urban design that fosters more integrated environments.

Exposure to the complex mix of pesticides used in agriculture in Europe significantly reduces bumblebees’ health. This suggests that current risk-assessment processes, in which pesticides are assessed separately, are not fit for purpose. Continuous monitoring is needed to quantify the real-world effects of pesticides on pollinator health.

The full promise of materials structured at the nanoscale can be realized only if they can be manufactured more efficiently and at the sizes required for device integration. An innovative method takes advantage of thermodynamic and kinetic effects to control the growth of stacked 2D nanosheets that can be used for practical applications from the nanoscale to the macroscale.

The spike protein of BA.2.86 — a subvariant of Omicron — has a large number of mutations, and binds to its receptor in host cells with high affinity. Despite these characteristics, BA.2.86 is no more resistant to antibodies from vaccinated individuals than are the dominant variants that are currently in circulation.

Clostridioides difficile can form iron-storage organelles known as ferrosomes. These protect bacteria from iron toxicity and promote infection by acting as a countermeasure to the host’s defence mechanism of iron sequestration.

In 2019, Cyclone Idai caused devastating flooding in Mozambique’s Gorongosa National Park when ecological studies of mammals were already under way. Small-bodied species and those in low-lying areas were affected most, suggesting that animals’ sensitivity to extreme weather depends on traits such as body size and habitat use.

Advanced materials engineered at the microscale have the potential to achieve unparalleled mechanical performance under extreme conditions. A laser-based characterization method enables the fast measurement of extreme properties in these materials, by extracting them from the sample’s vibrational ‘fingerprint’, without touching or permanently deforming the structure.