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Identifying nutrient dependencies of cancer cells is crucial for developing new therapies. The discovery that an aggressive type of cancer cell has a high uptake of vitamin B5 sheds light on the link between vitamin availability and tumour growth.
High-resolution structures of TAAR1 — the receptor bound by amphetamines and molecules called trace amines — reveal detailed interactions with ligand molecules that will inform efforts to design antipsychotic drugs.
Fatal renal dysfunction is often associated with tumour development. Fly and mouse data reveal evolutionarily conserved mechanisms that link tumours to renal failure and offer potential for future therapeutic approaches.
An expanded version of a human-genome database called gnomAD, containing 76,156 whole-genome sequences, has enabled investigation of how variants in non-protein-coding regions of the genome affect health.
An innovative method uses the intrinsic attractive force between silicon surfaces that are separated by a tiny gap to engineer structures that can confine light — offering an ideal set-up for manipulating single photons.
Scientists are tantalized by the many forms that carbon could adopt — some of which are predicted to have extraordinary properties. The synthesis of three new all-carbon molecules is therefore a source of excitement.
A study has revealed that eliminating extreme poverty would result in a relatively small increase in global greenhouse-gas emissions, dispelling the idea that efforts to combat climate change and poverty are incompatible.
Scientists have long sought to understand what drives biodiversity changes. A study unifies ideas about marine and terrestrial biodiversity in one explanatory framework, pointing to physical geography as dictating life’s trajectory.
A transcription factor in immune cells forms an unexpectedly ladder-like complex with two DNA molecules, allowing the expression of genes that these cells need to suppress harmful immune responses.
Increasingly intense wildfires in the United States could have profound impacts on natural habitats — potentially leaving hundreds of animal species struggling to recover.
In 2008, the first comprehensive sequence of a cancer genome was reported, ushering in a new era of molecular diagnostic, prognostic and therapeutic advances informed by an essential framework to understand cancer’s complexities.
A mismatch in how carbon emissions are reported could endanger nations’ best efforts to meet targets for curbing climate change. A method for translating between reporting conventions offers a path forward.
A curious topological structure known as a hopfion ring has been induced in a magnetic material. The first of its kind in 3D, the ring is a tantalizing prospect for several branches of computing development.
The space telescope has helped to determine the atmospheric composition of an exoplanet using the light spectrum of its host star. Spectral changes as the planet orbits the star reveal the long-sought presence of exoplanetary methane.
Genomic data from ancient humans who lived up to 7,400 years ago, sampled from across California and Mexico, unveil patterns of migration that could explain how some Indigenous languages spread in parts of North America.
The time frame of a species’ origins provides context for evolutionary questions. However, dates from fossils are often inconsistent with estimates from genetic data. Emerging evidence points to a new explanation for this discrepancy.
GPS data reveal that people travel far from home to buy food in the United States, challenging ideas about how access to food relates to unhealthy eating habits.
