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Drug resistance in malaria parasites is mediated by mutations in a transporter protein. The transporter’s structure reveals the molecular basis of how key mutations bring about resistance to different drugs.
A molecular catalyst dispersed on carbon nanotubes has been found to catalyse the electrochemical conversion of carbon dioxide to methanol — a liquid fuel and industrially useful bulk chemical.
The finding that a thin sheet of fibrous tissue under the skin contains a prefabricated, movable cellular sealant that can heal deep wounds might have implications for the treatment of scars and ulcers.
Scientists have engineered semiconducting nanocrystals called quantum dots that lack toxic heavy metals and are highly efficient light emitters. These nanostructures might be used in displays, solar cells and light-emitting diodes.
The configuration of middle-ear bones in an ancient fossil suggests that specializations suited to eating plants might have influenced how the jaw joint evolved to form the mammal’s ear.
A sophisticated imaging pipeline has been developed to track neurons in early-stage zebrafish embryos over time and space. It reveals how newborn neurons come together to build a spinal cord capable of locomotion.
Two studies in flies reveal the mechanism by which the brain’s directional system learns to align information about self-orientation with environmental landmarks — a process crucial for accurate navigation.
Cosmic explosions called γ-ray bursts are the most energetic bursting events in the Universe. Observations of extremely high-energy emission from two γ-ray bursts provide a new way to study these gigantic explosions.
Conventional technologies for virtual and augmented reality simulate interactive experiences through visual and auditory stimuli. A technology that adds sensations of touch could find uses in areas from gaming to prosthetic feedback.
Immunotherapy approaches seek to boost immune responses against cancer. A single antibody engineered to recognize three targets shows promise, when tested in animals, in improving the ability of T cells to target cancer.
Graphene coated with nanoparticles has been used to make wearable light sensors that measure the human pulse and blood oxygen levels from ambient light passing through tissue, offering a potential platform for health-care monitoring.
A crystal’s surface has been found to behave as a distinct material that has temperature-dependent electrical polarization — despite the rest of the crystal being non-polar.
Treatment options are limited for alcoholic hepatitis, a liver disease associated with high alcohol intake. Studies in mice reveal that the microorganisms responsible for this condition can be tackled by a viral treatment.
Ultrasensitive experiments on trapped antiprotons provide a window onto possible differences between matter and antimatter. Now they could also shed light on the identity of dark matter — the ‘missing’ mass in the Universe.
A multi-nozzle system has been devised that allows the 3D printing of objects using several viscous materials, thereby allowing control over the material properties of objects at the submillimetre scale.
Transposase proteins mediate the movement of ‘parasitic’ DNA segments in genomes. A series of structures of a transposase catches it in action, and highlights how these proteins evolved for use in immune systems.
The ultimate goal of genome editing is to be able to make any specific change to the blueprint of life. A ‘search-and-replace’ method for genome editing takes us a giant leap closer to this ambitious goal.
