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Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby changing human breast cell fate.
Ring-closing metathesis is a widely used chemical transformation that can generate organic macrocycle compounds; here, an approach is described by which the E-stereoisomer of a macrocycle is generated selectively, exemplified by synthesizing the antibiotic recifeolide and the anti-cancer drug pacritinib.
The mechanism of hydrogen spillover is described using a precisely nanofabricated model system, explaining why it is slower on an aluminum oxide catalyst support than on a titanium oxide catalyst support.
Subarcsecond localization of the repeating fast radio burst FRB 121102 shows that its source is co-located with a faint galaxy with a low-luminosity active galactic nucleus, or a previously unknown type of extragalactic source.
In general, if there are fewer Atlantic hurricanes, those near the US coast are more likely to intensify, whereas if there are many hurricanes, then those near the coast are more likely to weaken because of high local wind shear and low sea surface temperatures.
The chimaeroids are one of the four principal divisions of the living jawed vertebrates and their evolutionary origins have been hard to discern; here, the study of a skull of the extinct shark Dwykaselachus shows that the chimaeroids nest among the once fairly common and widespread symmoriiforms.
Structural differences in 40- and 42-residue-long amyloid-β fibrils seeded in vitro from the cortical tissue of patients with different clinical subtypes of Alzheimer’s disease suggest that different fibril structures form in different disease variants and with different peptide lengths.
Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.
Simulations of Pluto suggest that the sharp ridges in the Tartarus Dorsa region of Pluto are penitentes that formed over the past tens of millions of years.
