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Neuroscience

A local route to pain relief

Nature volume 449, pages 545–546 (2007)Cite this article

Local anaesthetics stop pain, but block all other sensations too. In rats, one molecular delivery vehicle makes an unusual local anaesthetic specific for pain — provided a little spice is added to the mix first.

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Figure 1: A spicy solution.

References

  1. Binshtok, A. M., Bean, B. P. & Woolf, C. J. Nature 449, 607–610 (2007).

    Article  ADS  CAS  Google Scholar 

  2. Cummins, T. R., Sheets, P. L. & Waxman, S. G. Pain 131, 243–257 (2007).

    Article  CAS  Google Scholar 

  3. Caterina, M. J. & Julius, D. Annu. Rev. Neurosci. 24, 487–517 (2001).

    Article  CAS  Google Scholar 

  4. Strichartz, G. R. J. Gen. Physiol. 62, 37–57 (1973).

    Article  CAS  Google Scholar 

  5. Armstrong, C. M. Q. Rev. Biophys. 7, 179–210 (1975).

    Article  Google Scholar 

  6. Doyle, D. A. et al. Science 280, 69–77 (1998).

    Article  ADS  CAS  Google Scholar 

  7. Yu, F. H., Yarov-Yarovoy, V., Gutman, G. A. & Catterall, W. A. Pharmacol. Rev. 57, 387–395 (2005).

    Article  CAS  Google Scholar 

  8. Hille, B. J. Gen. Physiol. 69, 497–515 (1977).

    Article  CAS  Google Scholar 

  9. Yanagidate, F. & Strichartz, G. R. Handb. Exp. Pharmacol. 177, 95–127 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Edwin W. McCleskey is at the Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA. mccleskeye@hhmi.org ,

    Edwin W. McCleskey

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  1. Edwin W. McCleskey
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McCleskey, E. A local route to pain relief. Nature 449, 545–546 (2007). https://doi.org/10.1038/449545a

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