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Griseofulvin inhibits Fungal Mitosis

Nature volume 244, pages 292–294 (1973)Cite this article

Abstract

GRISEOFULVIN is an antifungal antibiotic widely used for the treatment of human and animal dermatophytic infections. The in vivo antifungal activity of griseofulvin is a reflexion of its peculiar pharmacological properties for, after oral administration, it is specifically localized and concentrated in the keratinized cells of the skin, hair and nails. The invasive growth of dermatophytes parasitizing these tissues is inhibited and the infected tissue is removed by desquamation and the growth of new epidermal layers. Here we report the effects of griseofulvin on fungal mitosis.

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Author notes

  1. K. GULL

    Present address: The Biological Laboratory, University of Kent at Canterbury, Canterbury, Kent, CT2 7NJ

Authors and Affiliations

  1. Department of Microbiology, Queen Elizabeth College, Campden Hill Road, London, W8

    K. GULL & A. P. J. TRINCI

Authors
  1. K. GULL
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  2. A. P. J. TRINCI
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GULL, K., TRINCI, A. Griseofulvin inhibits Fungal Mitosis. Nature 244, 292–294 (1973). https://doi.org/10.1038/244292a0

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