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RNA–DNA hybrids are immunogenic species that can aberrantly accumulate in the cytoplasm after R-loop processing, linking R-loop accumulation to cell death through the innate immune response.
Culture and analysis of ‘Candidatus Lokiarchaeum ossiferum’—a member of the Asgard phylum—reveals an elaborate cell architecture with extensive membranous protrusions.
Optomechanical lattices in one and two dimensions with exceptionally low disorder are realized, showing how the optomechanical interaction can be exploited for direct measurements of the Hamiltonian, beyond the tight-binding approximation.
The retrosplenial cortex and superior colliculus of mouse form a neural circuit that specifically encodes shelter location, facilitating rapid escape from predatory threats.
In Caenorhabditis elegans, paternal exposure to ionizing radiation results in HIS-24 and HPL-1-dependent genome instability phenotypes, causing embryonic lethality in the offspring.
Somitoids and segmentoids—culture systems that recapitulate the formation of somite-like structures—reveal that an initial salt-and-pepper expression pattern of MESP2 in a newly formed segment is transformed into compartments of anterior and posterior identity through an active cell-sorting mechanism.
Polarization can exceed 60% at the leading edge of the inner part of the Vela pulsar wind nebula; in contrast with the case of the supernova remnant, the electrons in the pulsar wind nebula are accelerated with little or no turbulence in a highly uniform magnetic field.
A lifetime cartography of in vivo senescent cells shows that they are heterogeneous. Senescent cells create an aged-like inflamed niche that mirrors inflammation associated with ageing and arrests stem cell proliferation and tissue regeneration.
Evolutionary analyses of single-nucleus transcriptome data for testes from 11 species are reported, illuminating the molecular evolution of spermatogenesis and associated forces, and providing a resource for investigating the testis across mammals.
Ultrasmall monodisperse perovskite quantum dots are synthesized in situ on a substrate via ligand structure regulation, yielding the highest external quantum efficiency blue perovskite LEDs reported so far.
Behavioural studies with deafened rats show that locus coeruleus activity and plasticity are key to rapid adaptation to and long-term hearing performance with cochlear implants.
A 3D model of human segmentation and somitogenesis derived from induced pluripotent stem cells captures the oscillatory dynamics of the segmentation clock as well as morphological and molecular features of the developing embryonic axis and tail.
Convergent mutations in hotspots of the SARS-CoV-2 Omicron receptor-binding domain can cause immune evasion and maintain sufficient ACE2-binding capability.
Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune resistance mechanisms.
RibosomeST—a ribosome with a specialized nascent polypeptide exit tunnel—cotranslationally regulates the folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm.
Using particle-by-particle assembly and adiabatic manipulation of disorder, low-entropy, strongly correlated quantum fluids of light are constructed, opening up new possibilities for the preparation of exotic phases of synthetic matter.
The tomato spotted wilt orthotospovirus nonstructural protein NSs interferes with phytohormone signalling in plants to compromise plant defences by interacting with plant TCP21—this effect of the viral protein is counteracted by the plant NLR immune receptor protein Tsw.
The zebrafish segmentation clock drives sequential segmentation of somites by periodically lowering double-phosphorylated Erk and therefore projecting its oscillation on the double-phosphorylated Erk gradient.
