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As the recipients of the 2013 science Nobel prizes gather in Stockholm to celebrate and be celebrated, News & Views shares some expert opinions on the achievements honoured.
As the recipients of the 2013 science Nobel prizes gather in Stockholm to celebrate and be celebrated, News & Views shares some expert opinions on the achievements honoured.
As the recipients of the 2013 science Nobel prizes gather in Stockholm to celebrate and be celebrated, News & Views shares some expert opinions on the achievements honoured.
As the recipients of the 2013 science Nobel prizes gather in Stockholm to celebrate and be celebrated, News & Views shares some expert opinions on the achievements honoured.
Proliferation-driving mutations in haematopoietic stem cells often result in the loss of stem-cell properties. But at least one common oncogenic mutation seems to enhance both proliferation and stem-cell self-renewal. See Letter p.143
Ketolide antibiotics have been found to induce a ribosomal frameshift — a change in the way that RNA is translated — in bacteria. This promotes the expression of a gene for antibiotic resistance, and may have broader implications.
Large panels of human cancer cell lines have been profiled at the DNA, RNA and pharmacological levels to accelerate the search for cancer therapies. But two of those large data sets show only partial concordance. See Analysis p.389
Detailed observations of an intermittent ultraluminous X-ray source indicate that its emission is unlikely to be powered by mass accretion onto an intermediate-mass black hole as previously thought. See Letter p.500
This Analysis compares two large-scale pharmacogenomic data sets that catalogued the sensitivity of a large number of cancer cell lines to approved and potential drugs, and finds that whereas the gene expression data are largely concordant between the two studies, the reported drug sensitivity measures and subsequently their association with genomic features are highly discordant.
Analysis of a meteorite found in northwest Africa, prosaically named NWA 7533, indicates that it is the first sample of the regolith, or 'soil', of Mars, and is derived from the earliest Martian igneous crust yet identified. See Letter p.513
The shifting nature of positive and negative feedbacks in a woodland region invaded by an exotic grass sheds light on the complexity of managing natural systems. See Letter p.517
After three decades of unsuccessful efforts to develop small molecules that neutralize the cancer-causing Ras proteins, an approach has been found that opens up fresh avenues for anticancer research. See Letter p.548
In a bacterial population, some cells stay single and motile, whereas others settle down and form chains. A study now investigates the mechanisms that determine these outcomes. See Article p.481
Breaking waves place repeated loading on marine algae, which can lead to death by fatigue. But observations of one alga suggest that its joint structure, which lacks transverse connections, confers fatigue resistance.
Emissions of carbon dioxide from inland waters to the atmosphere are a crucial link in the global carbon cycle. A comprehensive analysis reveals that this connection is much stronger than was previously thought. See Article p.355
An analysis of North American drought variability over the past millennium shows that it is not unusual for widespread drought to persist for years, prompting fresh thinking about our ability to deal with such climate conditions.
The almost complete extinction of small mammals in forest islands within 25 years of the construction of a reservoir that fragmented the habitat provides a striking example of delayed biodiversity loss.
A random array of holes etched in a semiconductor structure, consisting of a periodic series of thin layers, has been demonstrated that emits mid-infrared laser radiation. The device could have sensing and imaging applications.
The recent entry of a 20-metre-wide celestial rock into Earth's atmosphere offered both a spectacular show and a source of invaluable data that advance our understanding of high-velocity impacts. See Letters p.235 & p.238
Many animals use culture, the ability to learn from others, but only humans create complex culture. A laboratory experiment tests which characteristics of our social networks give us this capacity. See Letter p.389
