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STING signalling is activated in metastatic cancer cells that exit from an immune-evasive dormant state, blocking their progression and cancer relapse.
Tracking the formation of cubic ice (ice Ic) using transmission electron microscopy and low-dose imaging shows preferential nucleation of ice Ic at low-temperature interfaces and two types of stacking disorder.
The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.
The gluonic gravitational form factor of the proton was determined using various models, and these analyses showed that the mass radius of the proton was smaller than the electric charge radius.
Analysis of ancient human DNA from the Swahili coast reveals that predominantly African female ancestors and Asian male ancestors formed families after around ad 1000 and lived in elite communities in coastal stone towns.
Chips with 256 × 256 memristor arrays that were monolithically integrated on complementary metal–oxide–semiconductor (CMOS) circuits in a commercial foundry achieved 2,048 conductance levels in individual memristors.
The cryo-electron microscopy structure of the Polycomb repressive deubiquitinase (PR-DUB) in complex with the H2AK119ub1 nucleosome provides insight into how the substrate specificity of PR-DUB is achieved.
Analysis of observations from the Atacama Large Millimeter/submillimeter Array showed evidence of the thermal Sunyaev–Zeldovich effect in the direction of the Spiderweb protocluster at a redshift of 2.156.
Pancreatic ductal adenocarcinoma cells show a specific dependency on ornithine aminotransferase-mediated ornithine synthesis from glutamine, providing an opportunity to develop targeted therapies with minimal toxicity for this cancer.
The authors report the cryogenic electron microscopy structures of human GSDMB in complex with Shigella IpaH7.8 and the GSDMB pore, shedding light on the molecular mechanisms of Shigella IpaH7.8 recognition and targeting of GSDMs and GSDMB pore formation.
By switching the nucleation preferences in aqueous systems of inorganic precursors to bias formation and growth at the air–liquid interface, the mechanistic formation of inorganic membranes from the floating-particle system is demonstrated.
A machine learning approach is used to analyse multi-omics (proteomics, metabolomics and transcriptomics) data, producing genetic scores for more than 17,000 biomolecular traits in human blood, and identifying possible associations with disease.
The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to target specific organisms and cell types for delivery of novel protein payloads.
Simulations show that projected increases in Antarctic meltwater will slow down the abyssal ocean overturning circulation over the coming decades and lead to warming and ageing of the ocean abyss.
A multiomics single-cell atlas of the human maternal–fetal interface including the myometrium, combining spatial transcriptomics data with chromatin accessibility, provides a comprehensive analysis of cell states as placental cells infiltrate the uterus during early pregnancy.
